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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 7 Documents
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Search results for , issue "Vol 20, No 3 (2015)" : 7 Documents clear
FORMULASI EKSTRAK ETANOL UMBI BAWANG TIWAI (Eleutherine americana) DALAM SEDIAAN KRIM ANTI ACNE Eka Siswanto Syamsul; Supomo Supomo; Heri Wijaya; Bramantyo Adi Nugroho
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.12 KB) | DOI: 10.22146/tradmedj.8860

Abstract

Bawang tiwai (Eleutherine americana) have antibacterial effect to Sthapylococus epidermis. This study was conducted to formulate an ethanolic extract of bawang tiwai into antiacne cream preparations, thus Dayak community empirically considered use this as an antiacne and boils. Formula (F) was made by varying the concentration of the ethanolic extract namely: F1 (1%), F2 (2%) and F3 (4%). Anti acne cream formulation tested with phytochemical screening, organoleptic (smell, color, homogenity), type of cream, cream dispersive test, and antibacterial activity test against Staphylococcus epidermidis. Phytochemical screening result shows that its contains alkaloids, flavonoids and saponins, organoleptic test showed stability in F3, antiacne cream has a pH value = 6. Dispersive cream generated meets the requirements with a range of 5-7 cm. Cream type is type O / W (oil in water). Test result by using  agar diffusion method with Mueller Hinton Agar (MHA) medium,  inhibition zone obtained in the negative control (0), F1 (0), F2 (5.17 ± 0,19mm) and F3 (6 ± 0,17mm), LSD oneway ANOVA showed 95% (p <0.05) compared F3 all treatments. This study antiacne cream of F3 (concentration of the ethanolic extract of bawang tiwai 4%) is the best formula with the greatest potential in the medium category against Staphylococcus epidermidis.
AKTIVITAS PENANGKAPAN RADIKAL 2-2’ DIFENIL-1-PIKRIL HIDRAZIL (DPPH) EKSTRAK ETANOLIK DAUN MENGKUDU (Morinda citrifolia L.), DAN BATANG BROTOWALI (Tinospora crispa L.), FRAKSI AIR SERTA FRAKSI AIR TERHIDROLISIS Tatang Irianti; Andayana Puspitasari; Machwiyyah L.; Rabbani HR.
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (988.927 KB) | DOI: 10.22146/tradmedj.8850

Abstract

We have investigated the antiradical activity of ethanolic extract of mengkudu leaves (Morinda citrifolia L.) and brotowali stem (Tinospora crispa L.) using radical scavenging assay or DPPH radical. Thin layer chromatograms were also studied to estimate the group of compounds that have antiradical activity.  The objective of this research was to compare the DPPH antiradical efficiency values of water fraction and acid hydrolyzed water fraction in both extracts. The radical scavenging IC50 value of ethanolic extract, water fraction, and hydrolised water fraction (one and thee hours) of mengkudu leaves were 75,65 µg/mL ; 98,68 µg/mL ; 36,27 µg/mL and 33,36 µg/mL  respectively. The IC50 value for brotowali stem were 33.75 µg/mL, 52.29 μg/mL, 31.12 μg/mL and 18.26 μg/mL.  The highest antiradical activity was the hydrolyzed water fraction three hour namely 200 µg/mL of this fraction was able to inhibit 33.12%  and 18.26 μg/mL DPPH radicals.
PENGARUH EKSTRAK ETANOLIK 50% HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP PENINGKATAN PROLIFERASI SEL LIMFOSIT MENCIT JANTAN GALUR Balb/c YANG DIINDUKSI VAKSIN HEPATITIS B Nikmah Nur Khusnawati; Suwijiyo Pramono; Ediati Sasmito
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.606 KB) | DOI: 10.22146/tradmedj.8861

Abstract

Pegagan (Centella asiatica (L.) Urban) has been known as multi effect plant that empirically used in the traditional medicine. This research aims to evaluate the effect of 50%ethanolic extract of pegagan herb against increased lymphocyte proliferation cells in Balb/c mice that induced with hepatitis B vaccine, and also to evaluate triterpen glicosida compound (asiaticosida) of 50% ethanolic extract of pegagan herb. The test was done by 60 Balb/c male mices that divided into 6 groups : control group, testing group that was treated with pegagan extract dose of 25 mg/KgBB, 50 mg/KgBB, 100 mg/KgBB, 200 mg/KgBB and 400 mg/KgBB. All of mices were vaccinated on day 0 and days 15. Furthermore, identification of triterpen glicosida compound was done by KLT method using BAW 4:1:5 as upper eluen. Lymphocyte cells were isolated and the cells proliferation measured by MTT reduction method. Data was analyzed statistically using 95% confidence level. The result shown that 50% of ethanolic extract of pegagan herb did not give  the immuomodulatory effect while the identification test shown that 50% of extract of pegagan herb has triterpen glicosida compound (asiaticoside).
EFEKTIVITAS KRIM ANTIJERAWAT EKSTRAK METANOL DAUN PACAR AIR (Impatiens balsamina L.) Abdurraafi&#039; Maududi Dermawan; Liza Pratiwi; Indri Kusharyanti
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.143 KB) | DOI: 10.22146/tradmedj.8851

Abstract

Many studies have found that Impatiens balsamina leaves contain antibacterial activity. The present study was conducted to evaluate antiacne effect from cream of methanolic extract from leaves of Impatiens balsamina L. towards Propionibacterium acnes and Staphylococcus epidermidis, which concentration that gives the most effective antiacne and to evaluate physical and chemical properties of creams. The simplicia was extracted by soxhlet technique and using methanol as solvent. Kirby-Baeur diffusion method was used to measure the antibacterial activity. The extract was formulated in cream with concentration of 10%, 15% and 20%. Evaluation of physical and chemical properties was done by organoleptic testing, spreadability, adhesive force, pH and antibacterial effectiveness. Data was analyzed using R-Commander program 2.14.1 Version. Formula II which contained 15% extract showed the most effective inhibiton to the growth of bacteria. The evaluation of FII cream showed that the cream was homogen, the spreadability was 21,24 + 1,464cm2, adhesive force more than 60 minutes, and pH of 6,53 + 0,057.
KETOKSIKAN AKUT EKSTRAK AIR Eupatorium riparium Reg. PADA TIKUS SPRAGUE-DAWLEY Nurlaila Nurlaila; Sita Rina Widyarini; Subagus Wahyuono; Lukman Hakim
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1050.003 KB) | DOI: 10.22146/tradmedj.8854

Abstract

Eupatorium riparium Reg. is one of medicinal plant that might be used to cure a disease optimally. Some research reports and traditional uses in society show that this plant can  be used as a diuretic, anti-inflammatory, hepatoprotective, immunostimulant, anti-malarial, and anti-infective agents. Therefore, it is necessary to evaluate its safety. The aim of this study is to determine the acute toxicity of the aqueous extract of E. riparium Reg. at Sprague-Dawley (SD) rats. The acute toxicity test was conducted using the method of OECD 423. Male SD rats were orally given aqueous extracts of E. riparium Reg. which was started with a dose of 2000 mg / kg. Observations were performed 24 hours after the administration with intensive observations on the first 4 hours. The result showed that there were no animals found in dead condition when treated with a dose of 2000 mg/kg; repeated testing is also showed that no animals died, so the observation was continued until 14 days. The dose was increased to 5000 mg/kg, and again there were no dead animals. From the results, it can be concluded that the potential for acute toxicity (LD50) (cut off) of aqueous extract of E. riparium Reg., in rats is > 5000 mg/kg. In addition, toxic symptoms such as restlessness, lick, hyperactivity, forced movement, paralysis of the  legs, dyspnea were shown but these symptoms were disappeared after 14 days. Histopathological study showed that there was no change on animal’s organ compared to the normal control. 
AKTIVITAS SITOTOKSIK HASIL PARTISI ETIL ASETAT EKSTRAK PETROLEUM ETER DAN EKSTRAK METANOL DAUN KAYU APU (Pistiae Folium) Sentot Joko Raharjo; Rahayu Wahyu Ningsih
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (814.252 KB) | DOI: 10.22146/tradmedj.8858

Abstract

This study aims to explore the cytotoxic test (LC50) towards Artemia salina L. larvae of the partition ethyl acetate fractions from methanol extracts and petroleum ether (PE) extracts of Pistiae folium. The leaves of Pistiae folium was extracted using solvents soxhletation with methanol solvent and petroleum ether solvent. Both extracts successively partitioned with n-hexane and ethyl acetate, respectively. Identification of secondary metabolites was using phytochemical screening method and TLC (Thin Layer Chromatography). TLC analysis was using the eluent chloroform: methanol 3: 1 by citroboric acid spot analysis. The cytotoxic activity was using Brine Shrimp Lethality Test (BSLT) method. The result of partition from methanol extracts was 6.25% and from PE extracts was 0.69%. The phytochemical screening test showed that it contained flavonoids, saponins and steroids. The TLC analysis identified flavonoid compounds. The cytotoxic activity (LC50) of the ethyl acetate partition from methanol extracts and petroleum ether extracts of Pistiae folium were 79.9298mg/mL and 51.7608mg/mL, respectively. The result showed that the cytotoxic activity of ethyl acetate fractions partitined from methanol extract of Pistiae folium was higher than the PE extracts.
AKTIVITAS PENANGKAPAN RADIKAL 2,2-DIFENIL-1-PIKRILHIDRAZIL OLEH EKSTRAK ETANOLIK BATANG BROTOWALI (Tinospora crispa (L.) Miers) DAN FRAKSI-FRAKSINYA Irianti, Tatang; Puspitasari, Andayana; Suryani, Ema
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (760.318 KB) | DOI: 10.22146/tradmedj.8095

Abstract

Batang brotowali (Tinospora crispa (L.) Miers) diketahui mengandung beberapa senyawa fenolik yang mempunyai aktivitas sebagai antioksidan. Penelitian ini bertujuan menguji aktivitas penangkapan radikal 2,2-difenil-1-pikrilhidrazin (DPPH) oleh ekstrak etanolik batang brotowali dan fraksi-fraksinya. Ekstraksi batang brotowali dilakukan dengan alat Soxhlet dan pembuatan fraksi-fraksinya secara partisi cair-cair menggunakan alat Liquid-Liquid Continuous Extraction (LLCE). Pelarut-pelarutnya adalah n-heksana dan etil asetat. Adanya golongan senyawa antiradikal dideteksi  dengan metode Kromatografi Lapis Tipis (KLT) dan aktivitas penangkapan radikal DPPH. Ekstrak etanolik, fraksi etil asetat, dan fraksi air memiliki aktivitas antiradikal dan mengandung senyawa golongan kumarin dan flavonoid. Fraksi etil asetat (200 µg/ml) mampu menangkap 53,57 % radikal DPPH yang merupakan aktivitas antiradikal tertinggi dan diikuti oleh fraksi air, ekstrak etanolik, dan fraksi n-heksana.

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