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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue " Vol 13 No 2, 2002" : 2 Documents clear
REDUCTION ABILITY OF CURCUMIN AND DERIVATIVES ON FERRI : A MOLECULAR DYNAMIC STUDY Ari Sudarmanto, Bambang Sulistyo; Margono, Supardjan Amir
INDONESIAN JOURNAL OF PHARMACY Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.157 KB) | DOI: 10.14499/indonesianjpharm0iss0pp77-85

Abstract

Molecular dynamics (MD) simulation has been applied to curcumin, 4-methyl curcumin and 4-isopropil curcumin. They have reducting activities on Ferri to Ferro. A computation method used is AM1 (Austin Model 1) semiempiric method. Studying of computation is arranged to theoretical studying of structure and reactivity relationship on these molecules without solvent interaction (in vacuo). The time of simulation is taken from 0 – 10 ps (pico secon) with interval 0,0005 ps on 300oK. The result of experiment that has been proposed from the MD simulation is the structure of conformation trajectory of each molecules. By considering total energy and potential energy changes to time of simulation, along with the change of bonding length, bonding angle, and the atomic charges of -diketon active site to time of simulation. Reactivity of these molecules are analyzed from the geometric shape of the active site indicated that 4-isopropyl curcumin was the most reactive than the other to produce complex with Ferri, while 4-methyl curcumin within the complex was easiest in the reduction of Ferri to Ferro.Key words : molecular dynamic, curcumin, reduction
PRESCRIPTION ANALYSIS: AN INVESTIGATION ON PRESCRIPTION LEGALITY IN THE PHARMACIES OF KOTAMADYA YOGYAKARTA Rahmawati, Fita; Oetari, R.A.
INDONESIAN JOURNAL OF PHARMACY Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.185 KB) | DOI: 10.14499/indonesianjpharm0iss0pp86-94

Abstract

A research has been carried out to identify whether prescriptions received in pharmacies at Yogyakarta district fulfilled the legality as the regulation concern. This included an investigation on prescription hand-writing, part of a prescription which has a potential to bring about a medication error due to misinterpretation.The study was conducted by collecting prescription samples, randomly picked-up (=5% and d=3%), from each of 12 pharmacies. Furthermore, other supporting data, such as questioner and interview, were also collected from 29 pharmacies involving 83 respondents (24 pharmacists and 59 technician assistants). Data were then analyzed descriptively.The result showed that prescriptions fulfilled the regulation was approximately 39.8%. The absences of sign or license number of prescriber, the date of prescription were only examples of the cause. Hand-writing of the prescriber was sometime so bad that causing difficulty to interpret especially name of medicine, dose, usage or administration, uncommon abbreviation, hence increasing the risks of medication error to happen.Key word: prescription, legality aspect of prescription, medication error

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