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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue " Vol 21 No 1, 2010" : 2 Documents clear
Pharmacokinetic profile of carbamazepine and its metabolites on Javanese and Chinese ethnics in Indonesia Djojosaputro, Mulyadi; ., Sugiyanto; Hubeis, A. Aziz; Ismadi, M.
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.066 KB) | DOI: 10.14499/indonesianjpharm0iss0pp1-7

Abstract

Carbamazepine  (CBZ)  is  an  anticonvulsant  widely  used  for  epilepsy treatment. However, it is difficult  to  establish suitable dosage  regimens  for  this drug because of the variation on its pharmacokinetics profiles. A lot of evidences indicate  that  ethnic  differences  may  affect  pharmacokinetics  and  hence  dosage requirements. The study was conducted to document pharmacokinetic profile of CBZ  and  its  metabolites  on  Javanese  and  Chinese  ethnics  in  Indonesia.  The study was carried out in 26 Javanese and 24 Chinese ethnics healthy volunteers, Blood  samples  were  collected  serially.  Carbamazepine  and  its  metabolites was  assayed  by  HPLC.  The  results  showed  that  no  significant  differences in  pharmacokinetic  parameters  were  observed  between  both  ethnics.  The values  of  AUC0-~, Cmax,  Tmax,  and  t1/2 CBZ  on  Javanese  ethnic  are  652.44  ± 254.79  µg/mL.h,  8.93  ±  3.58  µg/mL,  11.53  ±  2.16  h,  and  43.70  ±  12.50  h respectively,  while  on  Chinese  ethnic  are  830.27  ±  809.57  µg/mL.h,  13.29  ± 17.46  µg/mL,  9.97  ±  2,90  h,  and  41.27  ±  13.50  h,  respectively.  However,  a significant  interindividual  variation  in  CBZ  metabolism  was  observed  in  both ethnics  as  shown  in its  large  variation in metabolic  ratio.  The  metabolic  10,11-epoxide  CBZ  and  trans-10,11  CBZ  concentration  ratio  on  Javanese  ethnic are 0.07 ± 0.03 and 0.13 ± 0.14, while on Chinese ethnic are 0.35 ± 0.99 and 0.14  ±   0.11.   It  can  be  concluded,  that  the  Pharmacokinetic  of  CBZ  and  its metabolites  on  Javenes  ethnic  is  not  different  compared  to  Chinese  ethnic.  In addition, there  is  a  significant  interindividual  variation  in  pharmacokinetics profile on both ethnics.Key words: Carbamazepine, Javanese, Chinese, pharmacokinetics, epilepsy
Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method kofler and crystallization reaction Zaini, Erizal
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1024.512 KB) | DOI: 10.14499/indonesianjpharm0iss0pp31-37

Abstract

Identification of solid state interaction between TMP and SMZ by hot contact method Kofler and crystallization reaction had been carried out. The results of hot contact method Kofler shown formation a new crystalline habit as long and thin needle shaped on contact zone (mixing zone) between Solid TMP and SMZ. It had a different melting point in compared to its single component. Crystallization reaction between two of supersaturated solution of component TMP and SMZ in methanol solvent also indicated the growth of crystal habit as similar as  hot contact method Kofler. Solid state interaction between TMP and SMZ was confirmed by microscopic SEM, powder X-ray diffraction, and thermal DSC. Microscopic analysis by SEM showed significantly the change of habit and morphology of  crystal as long and thin needle shaped. New powder X-ray diffraction (PXRD) interferences peaks were observed in addition to PXRD interference peaks of each component that proved formation of cocrystalline phase. Thermogram DSC indicated a new  endothermic peak corresponding to melting point of a new cocrystalline phase at temperature 178,82 °C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase

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