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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 3 Documents
 1 
Search results for , issue " Vol 24 No 4, 2013" : 3 Documents clear
STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM. Bokshi, Bishwajit; Zilani, Md.Nazmul Hasan; Malakar, Aparajita; Roy, Debendra Nath; Shilpi, Jamil Ahmad; Sadhu, Samir Kumar
INDONESIAN JOURNAL OF PHARMACY Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.609 KB) | DOI: 10.14499/indonesianjpharm0iss0pp253-258

Abstract

The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activity. Again between the two fractions of crude ethanol extract ethyl acetate fraction of S.caseolaris stem have most significant antidiarrhoeal activity.Key words: analgesic, antidiarrhoeal, S.caseolaris, diclofenac sodium, loperamide.
PHARMACEUTICAL EXCIPIENTS: GLOBAL REGULATORYISSUES Dureja, Harish; Kumar, Dinesh
INDONESIAN JOURNAL OF PHARMACY Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.86 KB) | DOI: 10.14499/indonesianjpharm0iss0pp215-221

Abstract

An excipient may be defined as an ingredient that is intentionally added to a drug for purposes other than the therapeutic or diagnostic effect at the intended dosage. Excipients have functional roles in pharmaceutical dosage forms which include the suitable form of consistency, modulating solubility and bioavailability of active ingredients, enhancing stability of the active ingredients in finished dosage form and many others. In most of the developed countries, the excipients are regulated as an active pharmaceutical ingredient. In Europe, it is assumed that novel excipients need to be evaluated as new chemical entities. In United State, the Food and Drug Administration assesses and permits use excipients as part of new drug application. The lack of harmonized international regulatory guidelines leads to the formation of the International Pharmaceutical Excipients Council (IPEC) in 1991. The IPEC was found to calibrate with different countries like Japan, Europe and China to address prevalent industry concerns related to the international harmonization of excipients standards, the introduction of useful new excipients to market place, and development of safety evaluation guidelines for the excipients. In the present study, an attempt has been made to investigate global issues governing regulations of pharmaceutical excipients.Key words: pharmaceutical excipient, regulatory guidelines, IPEC
OPTIMIZATION AND IN VIVO EVALUATION OF MESALAMINE pH DEPENDENT COATED PELLETS FOR PROMISING ILEOCECAL TARGETING Gangurde, Hemant H; Chordiya, Mayur Ashoka; Tamizharasi, S.; Sivakumar, T.
INDONESIAN JOURNAL OF PHARMACY Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.981 KB) | DOI: 10.14499/indonesianjpharm0iss0pp277-288

Abstract

The present research is a challenge to design, optimized and evaluates mesalamine loaded burst release pH dependent coated pellets for possible ileo-cecal targeting to treat effectively Crohn’s disease. The novelty of this formulation is to release drug specifically and instantly in ileo-cecal region where the chances of Crohn’s disease is more frequent, without being released in upper gastrointestinal tract. Preliminary experimental batches are studied for micromeritic properties and in-vitro drug release. Formulation  showed desirable lag time of 5h and dissolution profile were further optimized by applying 32 full factorial design to study the effect of extent of coating (% w/w) Eudragit S100 and croscarmellose sodium over drug layered pellets. The regression equation generated for Q300 (lag time of 5h) = +5.72-31.97*A+0.82*B-0.49*A*B+26.36*A2-0.15*B2 and for Q390 (90% of drug release at pH7.2 within 90 minutes after lag time) = +84.63- 40.09*A+4.62*B. The drug release data of optimized formulation were close to that predicted by the model. Various kinetic models were applied to the all optimized batches. In vivo evaluation of optimized formulations was performed to assess macroscopic, microscopic and biochemical parameters in rats and performed. The present study demonstrates that the mesalamine enteric coated pellets successfully targeted at ileo-cecal region.Key words: Mesalamine, pulsatile, ileo-cecal targeting, celpheres, Croscarmellose sodium, eudragit S100

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