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Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Published by Universitas Brawijaya
ISSN : 20875517     EISSN : 25274376     DOI : -
Core Subject : Agriculture, Social,
Agriculture, Biological Sciences & Forestry Environmental Science
The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel findings of wide Tropical Life system phenomenon in the areas of biodiversity, agriculture, fisheries, health, husbandry, forestry and environmental technology. JTLS has 1 volume with 3 issues per year.
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol 7, No 1 (2017)" : 12 Documents clear
Study of Phytochemical, Anti-Microbial, Anti-Oxidant, Phytotoxic, and Immunomodulatory Activity Properties of Bauhinia variegata Bhandari, Jaya; Thapa, Pratiksha; Niraula, Prasodhan; Thapa, Nita; Shrestha, Nikita; Shrestha, Bhupal Govinda
Journal of Tropical Life Science Vol 7, No 1 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.01.14

Abstract

There is growing interest in the use plants for the treatment and prevention of cancer and are currently being evaluated as promising anticancer agents. In this paper, we investigated the anti-microbial, anti-oxidant, phytotoxic and immunomodulatory of plant Bauhinia variegata and also established the presence of important phytoconstituents which might signify its anticancer property. Phytochemical screening, anti-microbial assay, phytotoxicity assay, anti-oxidant assay and immunomodulatory analysis was done according to the protocol established at Department of Biotechnology, Kathmandu University and Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Pakistan.In the phytochemical screening, we observed the presence of different phytochemicals like steroids, terpenoids, flavonoids, reducing sugars and glycosides. In case of Antimicrobial assay, the plant was found to be most effective against B.cereus with the highest zone of inhibition (ZOI) of 12mm and against Rhizopus with ZOI of 11mm. During the antioxidant assay in comparison to Ascorbic acid; at highest concentration, the scavenging activity shown by the plant Bauhinia variegata are 43.38% as compared to ascorbic acid 89.25%. In the Immunomodulatory assay at the highest concentration i.e. 250 µg/ml, the plant showed 75.1% effect, which showed that the plant has potential anti-inflammatory potential. In phytotoxicity assay, Bauhinia variegata showed 20% phytotoxicity. Bauhinia variegata has thus been proven to be an important candidate to be used as an antimicrobial, antioxidant, anti-inflammatory, phytotoxic and anticancer agent. Separation of pure compounds with bioassay guided extraction, spectrometric analysis and subsequent cytotoxicity assay of the pure bioactive compounds from Bauhinia variegate is highly recommended as crude extract itself showed promising phytotoxicity and other pharmaceutical potential.
A Dynamical Analysis on a Tumour Virotherapy Model with Standard Incident Rate Ikawati, Deasy Sandhya Elya; Kusumawinahyu, Wuryansari Muharini; Trisilowati, Trisilowati
Journal of Tropical Life Science Vol 7, No 1 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.01.03

Abstract

This paper discusses a dynamical analysis on a model that governs the growth of tumour cell under a therapy by using oncolytic viruses, on the standard incident rate. The model is a modification of the similar one by replacing the bilinear incident rate with the standard one. The conducted dynamical analysis consists of the determination of equilibrium points and their existence conditions, followed by local as well as global stability analysis of the equilibrium points. The analytical result shows that there are two equilibrium points, namely uninfected and the endemic point, which needs a condition to exist. Stability analysis shows that there is a dimensionless basic reproduction number that marks the existence as well as the stability of equilibrium points. When basic reproduction number is less than one, there is only the uninfected equilibrium, which is global asymptotically stable. On the other hands, both of equilibrium points exist when the basic reproduction number is more than one, but the uninfected point is not stable anymore, while the endemic one is local asymptotically stable under a condition. Some numerical simulations are performed to illustrate the analytical result. Numerically, it can also be demonstrated that there is a set of parameters which indicates that tumour can be fully removed.  

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