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INDONESIA
Indonesia Chimica Acta
Published by Universitas Hasanuddin
ISSN : 2085014X     EISSN : 26556049     DOI : -
Core Subject : Engineering,
Chemical Engineering, Chemistry & Bioengineering
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Volume 15, No 2: December 2022" : 5 Documents clear
Pharmacology Analysis of The Active Compound of Makassar Fruit (Brucea Javanica) as Antidiabetic Via Bioinformatics Approach Arwansyah Arwansyah; Vivi Dia A Sangkota; Dewi Satria Ahmar; Magfirah Magfirah; Karina Nadya Sirajuddin; Adwi Restafara; Abdur Rahman Arif
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.21043

Abstract

Diabetes is one of the emergency diseases worldwide due to the large case each year. Therefore, searching the potential treatment become crucial to treating the disease. In this research, homology modeling and molecular docking were employed to analyze the active compounds of Makassar fruit (Brucea javanica) as antidiabetic. Alpha glucosidase (AG) is used as a target, and the ligands are javanicin and javanicisode B, both active molecules of Brucea javanica. According to molecular docking results, all ligands have the potential to bind to the receptor because of their negative energy scores. Also, javanicin has higher binding energy (-8.0 kcal/mol) than the control (-5.7 kcal/mol). Furthermore, hydrogen bonds and hydrophobic interactions allow these two active chemicals to attach to an important location on AG. Thus, our finding implied that two active compounds of Brucea Javanica could be inhibitors for the receptor, and javanicin may become a promising drug against diabetes.
Molecular Docking Analysis and ADMET Properties of Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors Herlina Rasyid; Mardiyanti Riska
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.21572

Abstract

Alzheimer’s disease (AD) are the progressive necrosis of central cholinergic neurons, followed by intra and hippocampal acetylcholine (ACh) levels. Acetylcholinesterase Enzyme (AChE) is an enzyme that is responsible for the metabolic breakdown of acetylcholine (ACh). The hydrolysis of ACh by excess amount of AChE decreases the amount of ACh in the brain, thus interfering with the normal brain functions. Modelling of seven isoquinoline derivative compounds is done by using Computer-Assisted Drug Design (CADD) such as molecular docking and ADMET properties calculation. The results obtained show that compound 13, 14, 16, and 17 have a lower binding energy about -9 kcal/mol. It can be caused due to the more electron donating groups in these compounds. ADMET properties calculation is attempted to evaluate the interaction between the four compounds (13, 14, 16, and 17) when entering the body systems. ADMET calculation result is showing that compounds 13 and 14 fulfill the parameter in adsorption properties while the others are not. Indicating that compounds 13 and 14 are potential to be Alzheimer’s drug. This result is in line with experimental study.
Quality Test of Corn Flour from Pulut Corn Cob Waste ( Zea mays ceratina. L) by Fermentation mirnawati mirna
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.18405

Abstract

Pulut type corn or waxy corn has been developed in several areas in South Sulawesi. From year to year, the productivity of corn pulut has increased, this also shows that agricultural waste production has also increased. The agricultural waste produced by corn cobs. The purpose of this study was to determine the processing of corncob waste into cornflour and to determine the characterization of the quality of cornflour, especially microbial contamination based on SNI standards. Methods: water content using a gravimetric method, ash content using a gravimetric method, microbial contamination test using ALT method of 25-250 colonies/gram counted, and analysis of mold and E. coli bacteria. The results showed that the ash content was 0.0766%, 17.49 % moisture content, 17.49% protein content, ALT 1.9 x 106, mold analysis of 10,4 x 102 colonies/gram, and analysis of E. coli bacteria amounting to 8,1 APM / g and Bacillus cereus with a resistance value of <1.0 x 102coloni/g (negative value) indicates that it does not meet the SNI standard.
Optimization of FeSO4 Molarity for Synthesis of Prussian Blue Pigment from Iron Sand from Sunur Beach Estuary, Pariaman Nafis Sudirman
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.20087

Abstract

The objective of this research was to see how the molarity of Iron(II) sulfate (FeSO4) solution affected the coloring of the Prussian blue pigment produced, to find the best synthesis conditions. The coprecipitation methods were used to synthesize Prussian blue from FeSO4 and K3[Fe(CN)6] solutions. The molarity of iron(II) sulfate (FeSO4) was varied to 0.005 M, 0.0025 M, and 0.00125 M in this research, with the resulting products referred to as K1, K2, and K3. The UV-Visible spectrophotometer was used to analyze the produced pigment. The molarity of Iron(II) sulfate (FeSO4) impacts the final Prussian blue pigment, as observed in the experiment with variations in the molarity of FeSO4. The optimum color of Prussian blue, with a peak near-standard UV-Visible spectra at 686 nm, was produced at 11.85 mM FeSO4 molarity, which was very much by the standard absorbance wavelength Prussian blue pigment.
The Effect of Titanium Dioxide Nanoparticle Composites as an Antibacterial in Synthesizing Polyurethane Biopolymers andibudirohmi andi rahmi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.24324

Abstract

Abstract. In the health sector, the use of polyurethane (PU) as a basic material for the manufacture of medical devices also creates problems related to local and systemic infections. One of the most appropriate ways to overcome this problem is to add titanium dioxide (TiO2) nanoparticles to the urethane polymer to produce a biodegradable polymer and bacterial decontamination. In synthesizing decontaminating polyurethane bacteria, several characterization techniques were carried out, including polymer test, namely strain and stress, functional group analysis using Fourier Transform Infra-Red (FTIR), and antibacterial test. Based on the results of the FTIR test analysis, shows a change in the functional group. At wave number 1724.36 cm-1, the N-H functional group appears, this absorption is the absorption of the urethane group and TiO2 is in the range of 513.07 cm-1. Mechanical properties test showed strain (28.92 - 21.88% GL) and young modulus at intervals (5,484-3,268 MPa). and the antibacterial test showed that the inhibitory power of test samples A1 and A4 with resistance diameters of 8mm and 8mm proved to be very effective in killing E.Coli bacteria while A1¹, A2¹, A3¹, and A4 killed could not kill S. Aureus bacteria inhibitors. The characterization results show that the polyurethane biopolymer can be used as a medical device with bacterial decontamination properties.

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