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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 4, Issue 3, Sep - November, 2022" : 5 Documents clear
Drug Delivery System in Feline Yedi Herdiana; Gofarana Wilar; Ferry Ferdiansyah Sofian; Annisa Dyah Pitaloka; Yasinta Nurhijriah; Rayhan Zarra Safira; Annisa Siti Salsabila; Maziyatunisa Z
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44274

Abstract

The drug delivery system is an attractive field of study since it has several applications in veterinary and human medicine. In the realm of veterinary medicine, the discovery of new routes of administration or new delivery systems to regulate the release of medications is of great importance. Due to the high number of animals and the special issues related to the administration of drugs and their market potential is very large, it is necessary to modify the dosage form to produce an effective and practicable preparation. Cats are the most popular pet in the world, outnumbering dogs by a ratio of three to one. It is vital to understand the prevalent illness patterns and limits of traditional delivery systems to establish appropriate dosage forms for cats. We believe this publication will be of interest to veterinarians and pharmaceutical scientists working in the field.
Nanoparticle Drug Delivery System Auliya Afinasari; Eri Amalia
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44254

Abstract

Drug Delivery System is a method of drug formulation, which aims to deliver the active substance to achieve a therapeutic effect in the body. Along with the development of science in the field of drug manufacturing technology, drug delivery systems have evolved from conventional to targeted delivery systems and even nanorobots, gene therapy, biological products, and long-term delivery systems.Among the drug delivery systems that have been developed, nanotechnology has been applied as a targeted delivery system such as in cancer treatment. This review is focused on nanotechnology especially in nanoparticle dosage forms, including liposomes, dendrimers, niosomes, micelles, solid-lipid nanoparticles, nanospheres, nanocapsules, and gold nanoparticles. The data were collected from 41 primary published journals and 20 supporting literatures. The basic principles, strategies, and carrier systems used in the manufacture of each preparation will be presented in this article, including prospects in the future for SOPs.
Formulation and Evaluation of Sunscreen Gel Combination of Bisoctrizole and Gotu Kola Extract (Centella asiatica (L.) Urban) Yanni Dhiani Mardhiani; Dadih Supriadi; Putri Hafisa Nur Islamiyah
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44919

Abstract

Gotu kola extract has antioxidant activity and contains flavonoids that can absorb maximum wavelengths of UV radiation. Bisoctrizole is a photoprotective agent to minimize sun damage. The Sun Protection Factor value of sunscreen can be increased by combining Bisoctrizole and Gotu kola extract as sunscreen in the form of a gel. This study aims to develop a sunscreen gel from a combination of Bisoctrizole UV filter material and Gotu kola extract which has good physical properties and sun protection efficacy. Gel evaluation was carried out on organoleptic, homogeneity, adhesion, dispersion, viscosity, syneresis, pH, irritation test, stability test, and in vitro test of SPF value (UV-Visible Spectrophotometry). The results showed that the combination sunscreen gel (F5-F7) had excellent physical appearance and homogeneity, no syneresis, pH 4.96±0.01 - 5.30±0.01, viscosity 5960±106 - 9240±173 cps, spreadability 5.75±0.05 - 6.38±0.03 cm, adhesion 1.24±0.20 - 2.89±0.12 seconds, and is non-irritating. The results of the measurement of sunscreen activity showed that the SPF value of the Bisoctrizole 5% gel added with Gotu kola extract 5% (F5); 7.5% (F6); and 10% (F7), respectively, were 27.73±0.04; 34.56±0.23; and 37.31±0.36. There was a significant difference (p<0.05) in the room temperature gel stability test and the cycling test on pH, viscosity, and spreadability.. The highest SPF value was found in the gel combination of Bisoctrizole 5% with Gotu kola extract 10% (F7) with an increase of 55.58%. Gotu kola extract can be formulated with Bisoctrizole into a sunscreen gel with ultra photoprotective activity (SPF>15).
Review: Preparation of Flavonoid Nanoparticles using the Nanoprecipitation Method Rizky Farhan Pratama; Iyan Sopyan; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.40849

Abstract

Flavonoids are polyphenolic compounds that have 15 carbon chains, 2 benzene rings and a heterocyclic pyran ring. From the literature study, it is known that flavonoids have various pharmacological activities such as anticancer, antimicrobial, antiviral, antiangiogenic, antimalarial, antioxidant, neuroprotective, antitumor, and antiproliferative agents. However, flavonoids have limited oral bioavailability which may be due to their poor solubility, low permeability, and low stability, which impair their effectiveness as therapeutic agents. One of the efforts to increase solubility is nanoparticle technology where the active compound particles are reduced to the nanometer scale, usually up to 100 nm. Nanoprecipitation is a method of preparing nanoparticles by dissolving the active drug substance and polymer into an organic solvent and then adding an anti-solvent such as water. The advantages of this method are the production is relatively fast, inexpensive, does not require a lot of energy, and does not require emulsion precursors. The purpose of this literature review is to examine the technique of making flavonoid nanoparticles using the nanoprecipitation method, the results of their characterization and evaluation. Based on a literature review that has been carried out on 30 journals, there are 20 flavonoid secondary metabolites that have been prepared into nanoparticles using the nanoprecipitation method. Some of the polymers used were effective in achieving satisfactory particle size, polydispersity index (PDI), Zeta potential and Encapsulation Efficiency (EE%). Thus, the nanoprecipitation method can be used to make flavonoid nanoparticles with optimal formulations to improve the physicochemical properties of flavonoids for drug development in the future.
Tableting Turmeric Rhizome (Curcuma domestica Val.) and Mangosteen Peel (Garcinia mangostana L.) Extract as Antioxidant Supplement Amalia Reyhani; Sriwidodo Sriwidodo; Anis Yohana Chaerunisa; Abd. Kakhar Umar; Evi Sylvia Nurrasjid; Mas Rahman Roestan
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.39667

Abstract

Free radicals are unstable molecules that lose electrons in their outer orbitals. These compounds can be toxins for the human body and cause various degenerative diseases. To avoid this, we need antioxidants. Examples of common sources of antioxidants are turmeric (Curcuma domestica Val.) and mangosteen rind (Garcinia mangostana L.). Both of these plants have very strong antioxidant activity but have a less favorable taste for consumption. This study aimed to obtain tablets containing turmeric rhizome and mangosteen rind extract that can cover the taste with a variety of binders. Subsequently, we observed the antioxidant  activity of two extracts before and after preparation. The tableting method was wet granulation and the characterization included the physical properties of the tablets. The levels of curcumin, alpha mangosteen, and total polyphenols were also checked. The antioxidant activity was measured using the DPPH method. Based on the characterization results, NaCMC 5% was the best binder for preparing tablets containing turmeric rhizome and mangosteen rind extract with a flow rate of 11.434 g/s, repose’s angle of 29.39ᵒ, loss on drying of 2.65%, carr’s index of 15.22, hardness of 43N, friability of 0.926%, and disintegration time of 16.44 minutes. The antioxidant test result showed that the combination of turmeric extract and mangosteen rind extract with a ratio of 1:2 had the best antioxidant activity with an IC50 value of 31.01 µg/ml, alpha mangosteen level of 29.77%, and curcumin level of 27.22%. The antioxidant activity of the preparation was not changed significantly after tableting. Based on the findings, it can be concluded that the tablet formulation of turmeric rhizome and mangosteen rind extract using 5% NaCMC can be potentially used as an antioxidant supplement.

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