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Raditya Iswandana
Fakultas Farmasi Universitas Indonesia
Health Professions Medicine & Pharmacology

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Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB)

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB) | DOI: 10.35617/jfi.v6i4.142

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Formulasi, Uji Stabilitas Fisik, dan Uji Aktivitas Secara In Vitro Sediaan Spray Antibau Kaki yang Mengandung Ekstrak Etanol Daun Sirih (Piper betle L.) Iswandana, Raditya; Sihombing, Lidya KM
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Betel leaf has long been proven and widely used in Indonesia for its antibacterial activities. Betel leaf 80% ethanolic extract has high compatibility to be made as a widely used pharmaceutical product, including spray. In 2014 American Podiatric Medical Association, studied a significant increase of foot odor prevalence between our citizens. One of the reasons of foot odor is caused by bacteria, mostly by Bacillus subitilis. This study focused on creating a pharmaceutical product with a strong antibacterial that showed minimum bactericidal concentration (MBC) towards bacteria that caused foot odor. Spray product was chosen because of the great pleasant experience for the user. The study tested various concentrations of betel leaf 80% ethanolic extract, to study its antibacterial activity. Furthermore, stability testing towards its physical property on 8-week storage in three different temperature; room temperature (28±2 ºC), high temperature (40±2 ºC), and low temperature (4±2 ºC), was also conducted. All formulae showed great physical stability profile on organoleptic parameters. Betel leaf 80% ethanolic extract, in the Formula 3 showed minimum bactericidal concentration (MBC) in 2 mm area with the Formula that contained ≥ 2 mg/ml ethanolic extract.
Challenge and Development Strategy for Colon-Targeted Drug Delivery System Iswandana, Raditya; Putri, Kurnia Sari Setio; Putri, Fathia Amalia; Gunawan, Maxius; Larasati, Sekar Arum
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Colon-Targeted Drug Delivery System (CTDDS) is able to improve local therapeutic effects in the treatment of colon-specific diseases, such as Crohn’s disease, Ulcerative Colitis (UC), and Irritable Bowel Syndrome (IBS). A colon can also be a suitable site for systemic delivery of drugs susceptible to extreme gastric pH, such as peptides and protein therapeutics. The physiological conditions of the gastrointestinal tract and the physicochemical properties of drugs are being considered to develop strategies and approaches to overcome emerging challenges. This review will discuss factors, challenges, strategies, and approaches to developing a colon-targeted drug delivery system.
Co-Authors Abdul Munim Effionora Anwar gunawan, maxius Kurnia Sari Setio Putri, Kurnia Sari Setio Larasati, Sekar Arum Mahdi Jufri Putri, Fathia Amalia Sihombing, Lidya KM