Article Per Year (5 Year)
p-Index From 2019 - 2024
0.751
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Jurnal Farmasi Klinik Indonesia JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Jurnal Kefarmasian Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Pharmaceutical Sciences and Research (PSR)
Mahdi Jufri
Fakultas Farmasi Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
ANALISIS INTERAKSI OBAT ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DI RUMAH SAKIT X DEPOK Purnasari, Santi; Jufri, Mahdi; Sari, Dini Permata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 1 (2008)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Oral antidiabetic medications has been used over 40 years to control blood glucosa level. Type 2 diabetes mellitus usually complicate with several chronic disease that cause diabetic therapy usually combined with other medications.  This increase the possibility of drug interaction. The present research was done to reveal the prescribing pattern and drug interaction problem in a hospital (Hospital X) at Depok. Data was collected from 307 prescriptions contain oral antidiabetic which were prescribe during January 2005-May 2006. Result showed that the most prescribe oral antidiabetic medication was glimepiride (45,89%). Drug interaction occurred in 41,69% prescriptions. Using statistical analysis Chi square it was revealed that there is significant correlation between the number of medication in one prescription with the number of drug interaction found.  ABSTRAK Obat antidiabetik oral telah digunakan selama 40 tahun terakhir untuk mengontrol kadar glukosa darah. Pada pasien diabetes melitus tipe 2 umumnya disertai dengan beberapa penyakit menahun, sehingga dalam terapi diabetes biasanya dikombinasikan dengan obat-obat lain. Hal ini meningkatkan terjadinya interaksi obat yang merugikan pasien. Penelitian ini bertujuan untuk mengetahui gambaran peresepan dan masalah interaksi obat di Rumah Sakit X Depok. Data diambil dari 307 resep obat antidiabetik oral selama bulan Januari 2005-Mei 2006. Obat golongan sulfonilurea yang paling banyak diresepkan adalah glimepirid (45,89%). Sebanyak 41,69% resep obat antidiabetik oral memiliki interaksi. Dengan menggunakan uji stastistik Kai Kuadrat diketahui adanya hubungan yang bermakna antara jumlah obat dalam satu resep yang mengandung obat antidiabetik oral dengan jumlah interaksi obat yang teridentifikasi.
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB)

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Instant Powder Formulation for Anti Anemia and Optimization Exctraction Condition of Moringa pterygosperma Gaertn Leaves Using MAE Anggraeni, Yosita; Jufri, Mahdi Jufri; Munim, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Iron supplement containing ferrous sulfate is commonly used for anaemia. Unfortunately, it has bad taste, can cause nausea, and made adverse effects if taken in large doses for long periods. It is necessary to ????ind an alternative source of raw materials, including those from plants. Moringa pterigospera Gaertn leaves was selected because it contains iron and other nutritions. The purpose of this work was to make instant powder formula for anti anaemia using Moringa leaves extract as an alternative for ferous suphate iron suplementation. The extraction was performed by Microwave Assisted Extraction method. Optimization of extraction condition was performed by creating some variations in solvent composition (0- 70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to10 min). Iron content was determined by Atomic Absorption Spectrophotometer at wave length of 248 nm. Instant powder formula was made in 3 concentrations of sodium CMC as suspending agent. Results of the study showed that the most optimal extraction condition which resulted the highest iron content (2.4 mg/g extracts) achieved with 900 watts microwave power, 10 min extraction time and aqua demineralisata. According to 30 panelists of hedonic test, formula which used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31% of loss on drying and 7.74 g/sec of ????low rate for powder form and pH of 5.78, viscosity of 15.98 cps for reconstituted form.
Uji Akvitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu pada Pertumbuhan Rambut Kelinci Febriani, Amelia; Elya, Berna; Jufri, Mahdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT :Hair loss affects one’s self image and emotional well-being. It is a very real and serious aesthetic concern for everyone. Leaves and flowers of Hibiscus are traditionally known to potentiate hair growth promotion. In this study we determine the hair growth promotion activity of hibiscus leaves using 2.5%, 5% and 10% of hibiscus leaf extract in the form of hair tonic. We also assessed the physical stability and safety of the hair tonic. Hair growth promotion activity assay was carried out by applying hair tonic on the rabbit’s back and measured hair length, hair thickness, hair weight and hair density. Physical stability assessment was performed at low (4°C ± 2°C), room (25°C ± 2°C) and high (40°C ± 2°C) temperature as well as the cycling test. Safety test was done by eye irritation test with HET-CAM and skin irritation test with patch test method. The results showed that hair tonic contains 10% of leaf extract have hair growth activity promotion better than the minoxidil 2%. Physical stability test showed extract of hibiscus leaf hair tonic has good physical stability. Results of safety test showed that there’s no skin irritation occurred while eye irritation test showed positive eyes iritation. Keywords: hibiscus leave, hair growth, hair tonic, HET-CAM, patch test  ABSTRAK: Kerontokan rambut yang sering diakhiri kebotakan merupakan problema estetis yang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telah diakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaan tradisional. Pada penelitian ini, 2,5%, 5% dan 10%  ekstrak daun kembang sepatu diformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dan tidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untuk mengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatu  stabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukan dengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukur panjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobot rambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukan pada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhu tinggi (40oC±2oC) serta  cycling test. Uji keamanan dilakukan dengan uji iritasi mata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test. Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10% memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrol positif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonic ekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil uji keamanan iritasi kulit  tidak terjadi iritasi, sedangkan hasil uji iritasi mata menunjukkan sediaan mengiritasi mata.Kata Kunci: daun kembang sepatu, pertumbuhan rambut, hair tonic, HET-CAM, patch test 
ANALISIS INTERAKSI OBAT ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DI RUMAH SAKIT X DEPOK Purnasari, Santi; Jufri, Mahdi; Sari, Dini Permata
Jurnal Farmasi Indonesia Vol 4, No 1 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i1.3

Abstract

Oral antidiabetic medications has been used over 40 years to control blood glucosa level. Type 2 diabetes mellitus usually complicate with several chronic disease that cause diabetic therapy usually combined with other medications.  This increase the possibility of drug interaction. The present research was done to reveal the prescribing pattern and drug interaction problem in a hospital (Hospital X) at Depok. Data was collected from 307 prescriptions contain oral antidiabetic which were prescribe during January 2005-May 2006. Result showed that the most prescribe oral antidiabetic medication was glimepiride (45,89%). Drug interaction occurred in 41,69% prescriptions. Using statistical analysis Chi square it was revealed that there is significant correlation between the number of medication in one prescription with the number of drug interaction found.  ABSTRAK Obat antidiabetik oral telah digunakan selama 40 tahun terakhir untuk mengontrol kadar glukosa darah. Pada pasien diabetes melitus tipe 2 umumnya disertai dengan beberapa penyakit menahun, sehingga dalam terapi diabetes biasanya dikombinasikan dengan obat-obat lain. Hal ini meningkatkan terjadinya interaksi obat yang merugikan pasien. Penelitian ini bertujuan untuk mengetahui gambaran peresepan dan masalah interaksi obat di Rumah Sakit X Depok. Data diambil dari 307 resep obat antidiabetik oral selama bulan Januari 2005-Mei 2006. Obat golongan sulfonilurea yang paling banyak diresepkan adalah glimepirid (45,89%). Sebanyak 41,69% resep obat antidiabetik oral memiliki interaksi. Dengan menggunakan uji stastistik Kai Kuadrat diketahui adanya hubungan yang bermakna antara jumlah obat dalam satu resep yang mengandung obat antidiabetik oral dengan jumlah interaksi obat yang teridentifikasi.
Formulasi Nanopartikel Verapamil Hidroklorida dari Kitosan dan Natrium Tripolifosfat dengan Metode Gelasi Ionik Iswandana, Raditya; Anwar, Effionora; Jufri, Mahdi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.205 KB) | DOI: 10.35617/jfi.v6i4.142

Abstract

Nanopraticles can be prepared by several methods and the ionic gelation method is the easiest one. Verapamil hydrochloride is a drug which used as antiarrhythmic, antiangina, and antihypertension therapy. Nevertheless, bioavailability of orally administered verapamil is very low, only about 10 to 23%. Therefore, verapamil hydrochloride was prepared as nanoparticles dosage form to increase its  bioavailability. The purpose of the present study was to optimize ionic gelation method of chitosan and sodium tripolyphosphate to obtain the best nanoparticles formulation. Nanoparticles were obtained from four different methods (formula A, B, C and D). Particle size distribution, zeta potential, entrapment efficiency, morphology, and fourier transform infra red spectrum of each nanoparticles formula were characterized. The chosen formula was formula D which has 62.8 nm of size, 59.15% of entrapment efficiency, ±25.46 mV of zeta potential, spherical shape, and the ionic interaction was confirmed by FT-IR spectrum. The result showed that chitosan-tripolyphosphate succesfully produce the verapamil hydrochloride nanoparticles by ionic gelation method.Keywords: chitosan, ionic gelation, nanoparticles, sodium tripolyphosphate, verapamil hydrochloride
Uji Akvitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu pada Pertumbuhan Rambut Kelinci Febriani, Amelia; Elya, Berna; Jufri, Mahdi
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1237.566 KB) | DOI: 10.35617/jfi.v8i1.234

Abstract

ABSTRACT :Hair loss affects oneâ??s self image and emotional well-being. It is a very real and serious aesthetic concern for everyone. Leaves and flowers of Hibiscus are traditionally known to potentiate hair growth promotion. In this study we determine the hair growth promotion activity of hibiscus leaves using 2.5%, 5% and 10% of hibiscus leaf extract in the form of hair tonic. We also assessed the physical stability and safety of the hair tonic. Hair growth promotion activity assay was carried out by applying hair tonic on the rabbitâ??s back and measured hair length, hair thickness, hair weight and hair density. Physical stability assessment was performed at low (4°C ± 2°C), room (25°C ± 2°C) and high (40°C ± 2°C) temperature as well as the cycling test. Safety test was done by eye irritation test with HET-CAM and skin irritation test with patch test method. The results showed that hair tonic contains 10% of leaf extract have hair growth activity promotion better than the minoxidil 2%. Physical stability test showed extract of hibiscus leaf hair tonic has good physical stability. Results of safety test showed that thereâ??s no skin irritation occurred while eye irritation test showed positive eyes iritation. Keywords: hibiscus leave, hair growth, hair tonic, HET-CAM, patch test  ABSTRAK: Kerontokan rambut yang sering diakhiri kebotakan merupakan problema estetis yang sangat dikhawatirkan setiap orang. Daun dan bunga kembang sepatu telah diakui memiliki aktivitas pertumbuhan rambut berdasarkan penggunaan tradisional. Pada penelitian ini, 2,5%, 5% dan 10%  ekstrak daun kembang sepatu diformulasikan dalam bentuk hair tonic karena penggunaannya lebih mudah dan tidak lengket seperti sediaan semisolid. Tujuan penelitian ini adalah untuk mengetahui aktivitas pertumbuhan rambut ektrak etanol daun kembang sepatu  stabilitas fisik dan keamanannya. Uji aktivitas pertumbuhan rambut dilakukan dengan mengoleskan sediaan hair tonic pada punggung kelinci dan diukur panjang rambut, ketebalan rambut (diameter rambut), kelebatan rambut (bobot rambut) dan kepadatan rambut (densitas rambut). Uji stabilitas fisik dilakukan pada penyimpanan suhu rendah (4oC±2oC), suhu ruang (25oC±2oC) dan suhu tinggi (40oC±2oC) serta  cycling test. Uji keamanan dilakukan dengan uji iritasi mata dengan metode HET-CAM dan uji iritasi kulit dengan metode patch test. Hasil menunjukkan bahwa sediaan hair tonic ekstrak daun kembang sepatu 10% memiliki aktivitas pertumbuhan rambut yang lebih baik dibandingkan kontrol positif minoksidil 2%. Hasil uji stabilitas fisik menunjukkan sediaan hair tonic ekstrak daun kembang sepatu memiliki stabilitas fisik yang baik. Dari hasil uji keamanan iritasi kulit  tidak terjadi iritasi, sedangkan hasil uji iritasi mata menunjukkan sediaan mengiritasi mata.Kata Kunci: daun kembang sepatu, pertumbuhan rambut, hair tonic, HET-CAM, patch test 
Instant Powder Formulation for Anti Anemia and Optimization Exctraction Condition of Moringa pterygosperma Gaertn Leaves Using MAE Anggraeni, Yosita; Jufri, Mahdi Jufri; Munim, Abdul
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.116 KB) | DOI: 10.35617/jfi.v7i3.306

Abstract

Iron supplement containing ferrous sulfate is commonly used for anaemia. Unfortunately, it has bad taste, can cause nausea, and made adverse effects if taken in large doses for long periods. It is necessary to 􏰁ind an alternative source of raw materials, including those from plants. Moringa pterigospera Gaertn leaves was selected because it contains iron and other nutritions. The purpose of this work was to make instant powder formula for anti anaemia using Moringa leaves extract as an alternative for ferous suphate iron suplementation. The extraction was performed by Microwave Assisted Extraction method. Optimization of extraction condition was performed by creating some variations in solvent composition (0- 70% ethanol), microwave power (450 to 900 watts) and extraction time (3 to10 min). Iron content was determined by Atomic Absorption Spectrophotometer at wave length of 248 nm. Instant powder formula was made in 3 concentrations of sodium CMC as suspending agent. Results of the study showed that the most optimal extraction condition which resulted the highest iron content (2.4 mg/g extracts) achieved with 900 watts microwave power, 10 min extraction time and aqua demineralisata. According to 30 panelists of hedonic test, formula which used 5% w/w of sodium CMC got the highest scores. Its powder form had 2.31% of loss on drying and 7.74 g/sec of 􏰁low rate for powder form and pH of 5.78, viscosity of 15.98 cps for reconstituted form.
Efektivitas Penerapan Automated Dose Dispensing di Bangsal Rawat Inap Rumah Sakit Umum Kabupaten Tangerang Abiyoga Pradata; Retnosari Andrajati; Mahdi Jufri; Ayup Milladi
Indonesian Journal of Clinical Pharmacy Vol 8, No 4 (2019)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2019.8.4.264

Abstract

Penerapan dan penelitian terkait efektivitas automated dose dispensing (ADD) di Indonesia masih sangat terbatas. Oleh karena itu, penelitian ini bertujuan untuk melihat efektivitas ADD di salah satu rumah sakit di Indonesia yang telah menerapkannya, yaitu Rumah Sakit Umum Kabupaten Tangerang. Metode penelitian yang digunakan adalah cross-sectional study dengan membandingkan jumlah dispensing error dan dispensing time dari populasi resep yang menggunakan ADD dan manual dispensing (MD). Sampel didapat dari resep unit dose dispensing (UDD) bangsal rawat inap RSU Kabupaten Tangerang periode Mei–Juli 2019. Hasil penelitian dari 1086 resep untuk masing-masing populasi menunjukkan terdapat perbedaan rata-rata geometrik dispensing time yang signifikan (p<0,001) antara ADD yaitu 53,70 (52,48–54,95) detik dengan MD yaitu 144,54 (141,25–147,91) detik. Hasil penelitian ini juga memaparkan terdapat perbedaan jumlah resep dengan dispensing error yang signifikan (p<0,002) antara ADD yaitu 44 errors dan MD yaitu 77 errors dengan nilai odds ratio sebesar 1,83. Hal ini menunjukkan bahwa di RSU Kabupaten Tangerang, ADD lebih efektif dibandingkan dengan MD dilihat dari rata-rata geometrik dispensing time dan jumlah resep dengan dispensing error. Meskipun ADD dapat mempercepat dispensing time dan menurunkan jumlah dispensing error, penting dilakukan telaah sebelum menerapkan mesin ini dengan mempertimbangkan faktor biaya, sistem informasi rumah sakit, resep elektronik, dan keterampilan sumber daya manusia.Kata kunci: Automated dose dispensing, dispensing time, dispensing error, dose dispensing Effectiveness of Automated Dose Dispensing Implementation in Inpatient Ward of Tangerang District General Hospital AbstractThe application and research related to the effectiveness of automated dose dispensing (ADD) in Indonesia is still very limited. Therefore, this study aimed to investigate the effectiveness of ADD in a hospital in Indonesia that have implemented this method, that is Tangerang District General Hospital. This research was cross sectional study by comparing the number of recipes with dispensing error and dispensing time of the recipe population using ADD and manual dispensing (MD). Samples were obtained from the prescription unit dose dispensing (UDD) inpatient ward of Tangerang District Hospital in the period of May–July 2019. The result of 1086 prescriptions for each population showed a significant difference (p<0.001) in the geometric mean of dispensing time between ADD 53.70 (52.48–54.95) seconds and MD 144.54 (141.25–147.91) seconds. There were differences in the number of recipes with a significant dispensing error (p<0.002) between ADD 44 errors and MD 77 errors with an odds ratio of 1.83. This shows that in Tangerang District General Hospital, ADD was more effective compared to MD in terms of the geometric mean of dispensing time and the number of prescriptions with dispensing error. Although ADD can speed up dispensing time and reduce the number of dispensing errors, it is important to conduct a study before implementing this machine by considering cost factors, hospital information systems, electronic prescriptions, and human resource skills.Keywords: Automated dose dispensing, dispensing time, dispensing error, unit dose dispensing
Masalah Farmasetika dan Interaksi Obat pada Resep Racikan Pasien Pediatri: Studi Retrospektif pada Salah Satu Rumah Sakit di Kabupaten Bogor Anna U. H. Rochjana; Mahdi Jufri; Retnosari Andrajati; Ratu A. D. Sartika
Indonesian Journal of Clinical Pharmacy Vol 8, No 1 (2019)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.193 KB) | DOI: 10.15416/ijcp.2019.8.1.42

Abstract

Di Indonesia, masih banyak dokter yang memberikan obat dalam bentuk racikan. Peracikan obat menjadi perhatian karena banyak munculnya kejadian yang tidak dikehendaki seperti masalah farmasetika dan interaksi obat. Penelitian ini bertujuan untuk menganalisis masalah farmasetika (inkompatibilitas) dan interaksi obat pada resep racikan pasien pediatri rawat jalan di salah satu rumah sakit di Kabupaten Bogor. Metode penelitian ini adalah gabungan penelitian kuantitatif dan kualitatif. Data diproses melalui software Lexicomp atau Drug Interactions Checker. Data  kualitatif  dalam bentuk triangulasi diperoleh dari wawancara mendalam, telaah resep dan observasi lapangan. Data yang diambil menggunakan total sampling sebanyak 506 lembar resep racikan rawat jalan periode Januari–Agustus 2016. Informan terdiri dari dua orang dokter spesialis dan dua orang apoteker. Hasil analisis menunjukkan terdapat masalah farmasetika (inkompatibilitas) sebesar 3,4% (17 lembar resep), masalah interaksi obat sebesar 45,1% (228 lembar resep), dan total interaksi obat sebanyak 329 interaksi obat. Persepsi dokter terkait masalah inkompatibilitas dan interaksi obat yaitu masalah-masalah yang terjadi disebabkan oleh masalah ketersediaan obat. Masalah farmasetika dan interaksi obat pada resep racikan dapat dihindari apabila ada informasi dari bagian farmasi mengenai obat yang ada interaksi dan obat yang tidak boleh diracik. Kata kunci: Inkompatibilitas, interaksi obat, pediatri, resep racikanPharmaceutics and Drug Interaction Problems in Pediatric Patients Prescription: Retrospective Study at a Hospital in Bogor DistrictAbstractIn Indonesia, many physicians still provide a lot of medicine in the form of compounding. Drug compounding is of concern considering the occurrence of unwanted events such as pharmaceutical problems and drug interactions that it caused. This study aimed to analyze the pharmaceutics problems (incompatibility) and drug interactions on compounding prescription of pediatric outpatients in one of the hospitals in Bogor district. This study used quantitative and qualitative research method. The data was processed through Lexicomp software or Drug Interactions Checker. Qualitative data in the form of triangulation was obtained from in-depth interviews, prescription analysis and observations. A total of 506 compounding prescriptions collected through total sampling in the period of January–August 2016. Informants consisting of two specialists and two pharmacists. Results of the analysis showed pharmaceutics problem (incompatibility) found was 3.4% (17 recipe sheets), problem of drug interaction was 45.1% (228 prescriptions), and the total of drug interactions were 329 drug interactions. Doctor’s perception was that the availability of drugs is the root of problems related with incompatibilities and drug interactions. Pharmaceutical problem and drug interactions in compounding prescriptions can be avoided provided that there is clear information from the pharmacy department regarding drug interactions and drugs that should not be compounded.Keywords: Compounding prescription, drug interaction, incompatibility, pediatrics
Co-Authors Abdul Munim Abiyoga Pradata Ahmad Fauzantoro Andre Fahriz Perdana Harahap Andri Pramesyanti Pramono Anggraeni, Yosita Anggraeni, Yosita Anisa Amalia Anna U. H. Rochjana Asnimar Binu, Asnimar Ayup Milladi Basra Ahmad Amru Berna Elya Cahyaningsih, Umi Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Fajriati Zulfa Febriani, Amelia Firli, Akhmad Ridwan Halimah Anggi Rahmani Henry . Joshita Djajadisastra JOSHITA DJAJADISASTRA Joshita Djajadisastra, Joshita Julia Rahmawati, Julia Kori Yati Kori Yati Kori Yati, Kori Kusuma, Ika Maruya Ledy Maya, Ledy Lusi Dwita Lusi Putri Dwita Makhdalena Makhdalena Mardiastuti Mardiastuti Mardiastuti Wahid Meiskha Bahar Misri Gozan Muhammad Yusuf Arya Ramadhan Nasihin Saud Irsyad Oktania Sandra Puspita Purnasari, Santi Purnasari, Santi Putri Margaining Utami, Putri Margaining Raditya Iswandana Ratu A. D. Sartika Retnosari Andrajati Retnosari Andrajati Rosmala Dewi SANDRA AULIA MARDIKASARI Sari, Dini Permata Sari, Dini Permata Septia Andini Sheila Azelya Fernanda Siti Sa’diah Suci Syafitri Utami Yohanna Aristanti Yudhi Nugraha