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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSFK (Jurnal Sains Farmasi & Klinis)
Ivonne Soeliono
Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats Hadisoewignyo, Lannie; Soeliono, Ivonne; Hartono, Sandy Budi; Hestianah, Eka Pramhyrta; Mahanani, Sri Rahayu
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (995.217 KB) | DOI: 10.14499/indonesianjpharm30iss2pp114-121

Abstract

It has been reported that curcumin has a hepatoprotective effect, but its low solubility limited its utilization. Recently there was so many emerging research of advanced curcumin formulation, such as nanoparticles curcumin. In our previous study, curcumin has been loaded into mesoporous silica nanoparticles (C-MSN). This study was performed both to evaluate of C-MSN hepatoprotective effect in CCl4-induced rats. Sixteen rats were divided into four groups, namely normal and CCl4 control, curcumin, C-MSN group. Treatment was given according to its group for fourteen days consecutively. At day 14, three hours after the last administration, CCl4 (1,25 ml/kgBB) were administered orally. Twelve hours later the rats were sacrificed, and blood samples were drawn from their hearts. Blood serum examination result revealed that C-MSN caused a significantly lower ALT and AST than CCl4 control group (851±271 U/L vs 1734±275 U/L; 295±155 U/L vs 1348±235 U/L; p<0.05). Its effect on hepatic serum level resembled curcumin group. However, the result was not supported by histology examination which showed a higher number of necrotic hepatic cells in C-MSN group than in the curcumin group (147±9 vs 80±16; p<0.05). From this study, it can be concluded that C-MSN revealed an excellent hepatoprotective property, but it was suspected that MSN itself has the toxic effect on the liver. A further study of MSN toxicity was needed to support its safety use. 
Pengaruh Gugus Metil pada Posisi Para dari Turunan 2-(P-Klorofenil)-Kuinazolin-4(3h)-On terhadap Aktivitas Analgesik pada Mencit Soeliono, Ivonne; Budiati, Tutuk; Tamayanti, Wahyu Dewi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2006

Abstract

This study has evaluated analgesic activity of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one and 3-(4-methylbenzylideneamino)-2-(p-chlorophenyl)-quinazoline-4(3H)-one. The purposes of this study were to measure analgesic activity, to compare their analgesic potency against mefenamic acid, and to determine the effect of methyl substituent addition on para position of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one toward analgesic activity in mice. Analgesic activity evaluation was performed in mice using writhing test method with acetic acid as pain inducer. The significance difference of writhing frequencies between each group was tested using one-way ANOVA followed by Tukey HSD test as a post-hoc test. The statistic comparison results showed that the synthesized drug and the reference compound had an analgesic activity, in which the synthesized drug had the same analgesic potency with mefenamic acid on the same dosage, and the addition of methyl substituent on para position of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one did not lead to the increase of analgesic activity in mice.
Evaluasi Penggunaan Antibiotik menggunakan Indeks ATC/DDD dan DU90% pada Pasien Operasi TAH BSO dengan Infeksi Daerah Operasi: Studi Retrospektif di RSUD Dr. Soetomo Claudia Devina Herdianti; Relly Yanuari Primariawan; Dwi Rahayu Rusiani; Ivonne Soeliono
Jurnal Sains Farmasi & Klinis Vol 7, No 3 (2020): J Sains Farm Klin 7(3), Desember 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.332 KB) | DOI: 10.25077/jsfk.7.3.188-193.2020

Abstract

TAH BSO adalah salah satu tindakan bedah ginekologi untuk menghilangkan uterus, serviks, kedua tabung tuba, dan ovarium. Tindakan bedah TAH BSO dapat meningkatkan risiko terjadinya Infeksi Daerah Operasi (IDO). IDO menjadi penyebab utama dari morbiditas, rawat inap yang berkepanjangan, dan kematian sehingga penggunaan antibiotik diperlukan pada pasien yang mengalami IDO. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik dengan metode ATC/DDD dan DU 90% pada pasien operasi TAH BSO dengan kasus IDO di Ruang Merak RSUD Dr. Soetomo. Metode penelitian dilakukan secara observasional dan pengambilan data secara retrospektif berdasarkan rekam medik dengan mengambil waktu selama bulan Januari 2015 sampai Desember 2018. Hasil penelitian menunjukkan bahwa antibiotik metronidazol memiliki nilai DDD tertinggi yaitu sebesar 25,00 DDD/100 pasien-hari artinya diestimasikan dari 100 pasien TAH BSO dengan IDO ada 25 pasien yang menerima metronidazol 1,5 gram per hari. Sedangkan antibiotik yang termasuk dalam DU 90% yaitu metronidazol (47%), seftriakson (18,16%), amikasin (8,87%), levofloksasin (8,01%), dan gentamisin (6,41%). Untuk selanjutnya, evaluasi penggunaan antibiotik dengan metode Gyssens dapat dilakukan untuk mengetahui ketepatan penggunaan antibiotik.
Evaluasi Perencanaan Persediaan Antibiotik Secara Kuantitatif Di Instalasi Farmasi Rumah Sakit Tipe A Venna Laurensia; Gusti Noorrizka Veronika Achmad; Raswita Diniya; Ivonne Soeliono
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.49035

Abstract

Planning an inventory of antibiotics that are not good will cause problems in planning, which are over-supply of antibiotics (stagnant) and lack of antibiotic stock (stockout). In this study an quantitative evaluation of antibiotic inventory planning was carried out using the Economic Order Quantity (EOQ) and Maximum-Minimum Stock Level (MMSL) control methods in 2017 at Type A Hospital’s Pharmacy Department. The EOQ method aims to minimize the number of orders while the MMSL method is used to determine the minimum and maximum stock of antibiotics that must be ordered. The results were compared with the need for 2018 then calculations are carried out to determine the amount of stagnant and stockout antibiotics. The number of antibiotics that were stagnant by EOQ method simulation was 44.73% and by MMSL method was 48.02%, while the number of antibiotics stocked by EOQ method was 38.15% and by MMSL method was 42.76%. The category of antibiotic supplies in 2018 in real terms which was included in a stagnant state was 23.68%, stockout ie 55.26% of 152 antibiotics. Evaluation of antibiotic inventory planning using the EOQ method results in the calculation of lower order quantities while the number of orders with MMSL is higher. To find out more broadly about the evaluation of inventory planning in the hospital needed further research by taking into account all drugs not just antibiotics.
Co-Authors Claudia Devina Herdianti Diniya, Raswita Dwi Rahayu Rusiani Gusti Noorrizka Veronika Achmad Hartono, Sandy Budi Hestianah, Eka Pramhyrta Lannie Hadisoewignyo Laurensia, Venna Mahanani, Sri Rahayu Raswita Diniya Relly Yanuari Primariawan Tutuk Budiati Venna Laurensia Wahyu Dewi Tamayanti, Wahyu Dewi