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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE International Journal of Islamic and Complementary Medicine Jurnal RSMH Palembang eJournal Kedokteran Indonesia Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Oktariana, Desi
Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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EFFECT OF JATI BELANDA LEAVES EXTRACT ON MYELOPEROXIDASE LEVEL IN WISTAR RAT'S LUNG INDUCED CONTUSION PULMONUM Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10009

Abstract

Pulmonary contusions are injuries to the lung parenchyma that often result from blunt trauma to the chest wall. This injury will activate the inflammatory response which can produce the effects of oxidative stress so that eventually lung damage occurs. Several studies have identified the effects of Jati Belanda leaves extracts related to the inflammatory process and their effects as antioxidants. This research is an in vivo experimental study with a prepost-test with control group design approach that aims to determine the effectiveness of the extracts of Jati Belanda (Guazuma ulmifolia) in its protection against pulmonary alveolar cells by pretreatment pulmonary contusions. The subjects of this study were white rats (Rattus norvegicus) Wistar strain which were divided into 5 groups namely positive control, negative control, Dutch teak leaf extract 125 mg / kgBB, 250 mg / kgBB and 500 mg / kgBW. Rats were induced by dropping a weight of 400 grams as high as 50 cm. The results of the study of Jati Belanda Leaf Extract (EDJB) all doses and positive control can significantly reduce levels of myeloperoxidase expression (p <0.05). Therefore, it can be concluded that the extracts of Jati Belanda leaves (Guazuma ulmifolia) are all effective doses in reducing the expression of myeloperoxidase in pulmonary tissue of Wistar rats induced by pulmonary contusions.
Identifikasi Polimorfisme Titik -1082 Promoter Gen IL-10 pada Penderita Kusta Oktariana, Desi; Argentina, Fifa; Lusiana, Evi; Tamzil, Nia Savitri
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Leprosy is a chronic disease caused by Mycobacterium lepraeinfection, which affects skin and nerves, then can result in disability. Interleukin-10 have an important role in the pathogenesis of leprosy. Polymorphism in this gene promoter is thought to affect IL-10 production, which can then influence the process of microbial elimination in the development of leprosy. One of the most common polymorphisms associated with IL-10 is the polymorphism of the -1082 on the gene promoter. The purpose of this study was to identify the polymorphism of the -1082 interleukin-10 gene promoter in leprosy patients treated at RSUP dr. Mohammad Hoesin Palembang. This research is an observational descriptive study with cross sectional design. Polymorphism of -1082 interleukin-10 gene promoter was measured by PCR-RFLP method, electrophoresis, and visualized in UV light. From this study it was found that the frequency distribution of genotype AA was 80%, AG was 14%, and GG was 6%. The frequency distribution of allele A is 87% and allele G is 13%. Wild type genotype is more common in leprosy sufferers (80%).
Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients Adil, Mahvira Chow Liana Herman; Nopriyati, Nopriyati; Oktariana, Desi; Kurniawati, Yuli; Prasasty, Gita Dwi
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.272

Abstract

Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results.
Efek Ekstrak Daun Jati Belanda terhadap Kadar Myeloperoxidase Jaringan Paru Tikus Putih Wistar Model Kontusio Pulmonum Nia Savitri Tamzil; Evi Lusiana; Desi Oktariana
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Kontusio pulmonum adalah cedera pada parenkim paru yang sering terjadi akibat trauma tumpul pada dinding dada.Cedera ini akan mengaktivasi respon inflamasi yang dapat menghasilkan efek stres oksidatif sehingga akhirnya terjadikerusakan jaringan paru. Beberapa studi mengindentifikasi efek ekstrak daun jati belanda terkait proses inflamasi danefeknya sebagai antioksidan. Penelitian ini merupakan studi eksperimental secara in vivo dengan pendekatan prepost-test with control group design yang bertujuan mengetahui efektivitas ekstrak daun jati belanda (Guazuma ulmifolia)dalam proteksinya terhadap sel alveolar paru dengan praperlakuan kontusio pulmonum. Subyek penelitian ini ialah tikusputih (Rattus norvegicus) galur Wistar yang terbagi menjadi 5 kelompok yaitu kontrol positif, kontrol negatif, ekstrakdaun jati belanda 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB. Tikus diinduksi dengan menjatuhkan beban seberat400 gram setinggi 50 cm. Hasil penelitian Ekstrak Daun jati belanda (EDJB) semua dosis dan kontrol positif dapatmenurunkan kadar ekspresi myeloperoksidase secara signifikan (p<0.05). Oleh karena itu, dapat disimpulkan ekstrakdaun jati belanda (Guazuma ulmifolia) semua dosis efektif dalam menurunkan ekspresi myeloperoxidase pada jaringanpulmo tikus putih Wistar yang diinduksi kontusio pulmonum.
OPTIMALISASI PENGETAHUAN TOKOH MASYARAKAT MENGENAI PENYAKIT ASAM URAT MELALUI SOSIALISASI KESEHATAN Evi Lusiana; Nia Savitri Tamzil; Nita Parisa; Desi Oktariana; Gita Dwi Prasasty; Indri Seta Septadina
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.16580

Abstract

Penyakit asam urat merupakan dalah satu penyakit yang banyak diderita masyarakat yang ditandai dengan rasa nyeri pada persendian yang disebabkan endapan kristal monosodium urat pada sendi. Sosialisasi kesehatan merupakan upaya perubahan perilaku manusia yang dilakukan melalui pendekatan edukatif. Tujuan enelitian ini mengetahui pengaruh sosialisasi kesehatan mengenai penyakit asam urat terhadap peningkatan pengetahuan pada tokoh masyarakat. Desain penelitian adalah pra eksperimental one group pra test post test design. Sampel yang diambil sebanyak 70 responden yang berasal dari tokoh masyarakat di Kelurahan Kutobatu Palembang, Sumatera Selatan. Data penelitian ini di ambil dengan menggunakan kuesioner. Data dianalisis dengan mengunakan uji wilcoxon dengan tingkat kemaknaan 0,05. Hasil penelitian menunjukan tingkat pengetahuan sebelum intervensi berada pada kategori kurang dengan persentase 75% dan sesudah intervensi berada pada kategori baik dengan persentase 90%. Hasil uji statistic wilcoxon dimana p-value=0,02 < ?=0,05. Dapat disimpulkan terdapat pengaruh sosialisasi kesehatan terhadap peningkatan pengetahuan tokoh masyarakat di Kelurahan Kutobatu Palembang, Sumatera Selatan.
PREVALENCE AND SENSITIVITY PATTERN OF GRAM-NEGATIVE BACILLI MULTIDRUG-RESISTANT (MDR) IN MOHAMMAD HOESIN HOSPITAL PALEMBANG Desi Oktariana; Vena Sabputri Sutrisno; Mastiar Endang Frida Siahaan; Phey Liana; Lusia Hayati
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.13796

Abstract

PELUANG TERJADINYA IMMUNIZATION STRESS-RELATED RESPONSE (ISRR) SELAMA PROGRAM VAKSINASI COVID-19 Hafizzanovian Hafizzanovian; Desi Oktariana; Muhammad Ali Apriansyah; Yuniza Yuniza
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V8I3.13807

Abstract

Coronavirus Disease 2019 (COVID-19) telah menjadi bencana katasropik dalam berbagai bidang, terutama bidang kesehatan. Mengingat mortalitas yang tinggi dan penyebaran yang cepat dari penyakit ini, vaksin menjadi salah satu harapan terbesar untuk dapat mengendalikan pandemi ini. Immunization stress-related response (ISRR) merupakan salah satu Kejadian Ikutan Pasca imunisasi (KIPI) yang bermanifestasi sebagai respons stres akut, reaksi vasovagal, atau reaksi gejala neurologis disosiatif (dissociative neurological symptom reactions atau DNSR) yang dapat muncul tepat sebelum, selama, atau segera setelah imunisasi. Fenomena kluster ISSR seringkali disebut juga dengan penyakit psikogenik massal. Adanya stigma negatif terhadap efektifitas dan keamanan vaksin Covid-19 dapat membuka peluang terjadinya kluster ISRR yang dapat membuat masyarakat semakin sungkan untuk menerima imunisasi sehingga menyebabkan gagalnya program imunisasi. Langkah preventif dapat meminimalkan risiko ISRR, dan jika ISRR terjadi, maka identifikasi yang cepat, diagnosis, dan manajemen yang tepat dapat mengurangi dampaknya.
DISTRIBUTION OF -819 INTERLEUKIN-10 PROMOTER GENE POLYMORPHISMS AMONG LEPROSY PATIENTS Desi Oktariana
Majalah Kedokteran Sriwijaya Vol 53, No 1 (2021): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v53i1.10526

Abstract

Kusta merupakan penyakit infeksi  kronik dari M. leprae yang menyebabkan kerusakan pada kulit dan saraf.Prevalensi penyakit kusta terus meningkat, terutama di Indonesia, yang termasuk salah satu daerah endemik kusta. Respon imun tidak hanya menentukan kerentanan individu untuk terkena penyakit kusta, tapi juga menentukan tipe kusta yang akan bermanifestasi. Salah satu sitokin yang memainkan peranan penting dalam patogenesis penyakit kusta adalah interleukin-10 (IL-10), yang bekerja pada makrofag yang aktif untuk mengakhiri respons terhadap mikroba dan mengembalikan sistem ke keadaan istirahat setelah mikroba dihancurkan. Peningkatan regulasi IL-10 dapat berpengaruh pada penurunan aktivitas makrofag dalam membunuh bakteri. Polimorfisme pada titik -819 diduga dapat berpengaruh pada ekspresi gen IL-10 yang dihasilkan. Penelitian ini bertujuan untuk  mengidentifikasi polimorfisme titik -819 promotor gen interleukin-10 pada penderita kusta yang dirawat di RSUP dr. Mohammad Hoesin Palembang. Penelitian ini merupakan penelitian deskriptif observasional dengan rancangan cross sectional. Polimorfisme titik -819 promotor gen interleukin-10 diukur dengan  metode   PCR-RFLP, elektroforesis, dan divisualisasi pada sinar UV. Dari penelitian ini didapatkan distribusi frekuensi genotipe TT sebesar 42%, CT sebesar 44%, dan CC sebesar 14%. Distribusi frekuensi alel T sebesar 32% dan alel C sebesar 18%. Gambaran genotip wild type lebih banyak ditemukan pada penderita kusta (80%).Kata kunci        : kusta, polimorfisme, interleukin-10
Disease Severity Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients at Dermatology and Venereology Outpatient Clinic of Dr. Mohammad Hoesin General Hospital Palembang Mahvira Chow Liana Herman Adil; Nopriyati; Desi Oktariana; Yuli Kurniawati; Gita Dwi Prasasty
Jurnal RSMH Palembang Vol. 2 No. 1 (2021): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (885.042 KB) | DOI: 10.37275/jrp.v2i1.11

Abstract

Studies on the severity of chronic spontaneous urticaria based on the results of theAutologous Serum Skin Test (ASST) have been done before, but the results vary so thereare still differences of opinion among some researchers. This study aims to determinethe correlation between disease severity and ASST results in chronic spontaneousurticaria patients at the Dermatology and Venereology (DV) Polyclinic of Dr. MohammadHoesin (RSMH) Palembang. The type of this study is analytic observational with cross-sectional design which used secondary data in the form of medical records. There were110 samples of chronic spontaneous urticaria patients at the DV clinic and it is 76samples that met the inclusion criteria. The highest distribution of chronicspontaneous urticaria patients was in the 17-25 year age group (23.7%) and the femalegroup (64.5%). The majority of chronic spontaneous urticaria patients had negativeASST results (52.6%) and mild disease activity (63.2%). Bivariate analysis showed nosignificant correlation between urticaria activity (UAS7 score) and ASST results with avalue of p = 0.287 or p > 0.05.
ASSOCIATION BETWEEN METABOLIC SYNDROME AND CORONARY HEART DISEASE IN WOMEN PATIENTS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG Desi Oktariana
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.13809

Abstract

Metabolic syndrome is still a risk factor for coronary heart disease. This study aims to analyze the association between metabolic syndrome and coronary heart disease in women. This study is an observational analytic study using a cross-sectional design on 138 samples selected using consecutive sampling method and data were collected through observation of the medical records of patients at dr. Mohammad Hoesin Palembang. The results showed that the highest proportion of metabolic syndrome components in the sample of this study was hypertension (54.3%), while the lowest was hyperglycemia (26.8%). This study found a significant relationship between metabolic syndrome and coronary heart disease in female patients (p = 0.047). Female patients with metabolic syndrome had a 2.218 times greater risk of developing coronary heart disease (PR 2.218 95% CI = 1.072 - 4.587).
Co-Authors Adil, Mahvira Chow Liana Herman Arina P Jatmiko Bella Puspita Aziatri Bintang Fajarullah Carolina Maria Sidabutar Evi Lusiana Fifa Argentina Gita D. Prasasty Gita Dwi Prasasty Hafizzanovian Hafizzanovian Indri Seta Septadina Kemas Y. Rahadiyanto Khaira Eskalatin Legiran Legiran Lusia Hayati Mahvira Chow Liana Herman Adil Mastiar Endang Frida Siahaan Muhammad Ali Apriansyah Mutiara Budi Azhar Nia S. Tamzil Nita Parisa Nopriyati Nopriyati, Nopriyati Phey Liana Safira Smaradhna Vena Sabputri Sutrisno Yuli Kurniawati Yuli Kurniawati, Yuli Yuniza Yuniza Zaviera Az Zahra