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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE International Journal of Islamic and Complementary Medicine Jurnal RSMH Palembang eJournal Kedokteran Indonesia Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Oktariana, Desi
Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : Biomedical Journal of Indonesia

 1 
EFFECT OF JATI BELANDA LEAVES EXTRACT ON MYELOPEROXIDASE LEVEL IN WISTAR RAT'S LUNG INDUCED CONTUSION PULMONUM Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10009

Abstract

Pulmonary contusions are injuries to the lung parenchyma that often result from blunt trauma to the chest wall. This injury will activate the inflammatory response which can produce the effects of oxidative stress so that eventually lung damage occurs. Several studies have identified the effects of Jati Belanda leaves extracts related to the inflammatory process and their effects as antioxidants. This research is an in vivo experimental study with a prepost-test with control group design approach that aims to determine the effectiveness of the extracts of Jati Belanda (Guazuma ulmifolia) in its protection against pulmonary alveolar cells by pretreatment pulmonary contusions. The subjects of this study were white rats (Rattus norvegicus) Wistar strain which were divided into 5 groups namely positive control, negative control, Dutch teak leaf extract 125 mg / kgBB, 250 mg / kgBB and 500 mg / kgBW. Rats were induced by dropping a weight of 400 grams as high as 50 cm. The results of the study of Jati Belanda Leaf Extract (EDJB) all doses and positive control can significantly reduce levels of myeloperoxidase expression (p <0.05). Therefore, it can be concluded that the extracts of Jati Belanda leaves (Guazuma ulmifolia) are all effective doses in reducing the expression of myeloperoxidase in pulmonary tissue of Wistar rats induced by pulmonary contusions.
Efek Ekstrak Daun Jati Belanda terhadap Kadar Myeloperoxidase Jaringan Paru Tikus Putih Wistar Model Kontusio Pulmonum Nia Savitri Tamzil; Evi Lusiana; Desi Oktariana
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kontusio pulmonum adalah cedera pada parenkim paru yang sering terjadi akibat trauma tumpul pada dinding dada.Cedera ini akan mengaktivasi respon inflamasi yang dapat menghasilkan efek stres oksidatif sehingga akhirnya terjadikerusakan jaringan paru. Beberapa studi mengindentifikasi efek ekstrak daun jati belanda terkait proses inflamasi danefeknya sebagai antioksidan. Penelitian ini merupakan studi eksperimental secara in vivo dengan pendekatan prepost-test with control group design yang bertujuan mengetahui efektivitas ekstrak daun jati belanda (Guazuma ulmifolia)dalam proteksinya terhadap sel alveolar paru dengan praperlakuan kontusio pulmonum. Subyek penelitian ini ialah tikusputih (Rattus norvegicus) galur Wistar yang terbagi menjadi 5 kelompok yaitu kontrol positif, kontrol negatif, ekstrakdaun jati belanda 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB. Tikus diinduksi dengan menjatuhkan beban seberat400 gram setinggi 50 cm. Hasil penelitian Ekstrak Daun jati belanda (EDJB) semua dosis dan kontrol positif dapatmenurunkan kadar ekspresi myeloperoksidase secara signifikan (p<0.05). Oleh karena itu, dapat disimpulkan ekstrakdaun jati belanda (Guazuma ulmifolia) semua dosis efektif dalam menurunkan ekspresi myeloperoxidase pada jaringanpulmo tikus putih Wistar yang diinduksi kontusio pulmonum.
Co-Authors Adil, Mahvira Chow Liana Herman Arina P Jatmiko Bella Puspita Aziatri Bintang Fajarullah Carolina Maria Sidabutar Evi Lusiana Fifa Argentina Gita D. Prasasty Gita Dwi Prasasty Hafizzanovian Hafizzanovian Indri Seta Septadina Kemas Y. Rahadiyanto Khaira Eskalatin Legiran Legiran Lusia Hayati Mahvira Chow Liana Herman Adil Mastiar Endang Frida Siahaan Muhammad Ali Apriansyah Mutiara Budi Azhar Nia S. Tamzil Nita Parisa Nopriyati Nopriyati, Nopriyati Phey Liana Safira Smaradhna Vena Sabputri Sutrisno Yuli Kurniawati Yuli Kurniawati, Yuli Yuniza Yuniza Zaviera Az Zahra