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All Journal Syntax Literate : Jurnal Ilmiah Indonesia Jurnal Farmasi Indonesia Jurnal Akuntansi, Perpajakan dan Auditing
Susilawati, Elis
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Humanities Economics, Econometrics & Finance Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Other

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Gambaran Penggunaan Insulin dan Metformin pada Diabetes Mellitus Gestasional-Literature Review Anggreini, Tyas Septiana; Susilawati, Elis; Sukmawati, Ika Kurnia
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3290.335 KB) | DOI: 10.36418/syntax-literate.v6i8.3807

Abstract

Diabetes Mellitus Gestasional (DMG) merupakan suatu gangguan intoleransi glukosa pada masa kehamilan. Terapi farmakologi yang umumnya diberikan yaitu Insulin dan obat hipoglikemik oral seperti metformin. Metformin sering digunakan pada pengobatan DMG saat ini. Metformin dapat melewati barrier plasenta, namun belum ditemukan adanya bukti kecacatan pada janin atau komplikasi pada bayi. Banyak penelitian melakukan uji coba untuk membandingkan efektivitas dan keamaan metformin pada ibu hamil. Tujuan review artikel ini yaitu untuk mengulas beberapa literature terkait efektivitas dan efisiensi penggunaan obat metformin yang dibandingkan dengan insulin pada DMG. Metode yang digunakan yaitu literature review dengan menggunakan data primer berupa artikel ilmiah atau jurnal, dilakukan penelusuran melalui database Google Scholar, Elsevier, atau PubMed dengan rentang tahun terbit 5 tahun terakhir. Hasil dari review artikel ilmiah menunjukan bahwa insulin tidak menjadi pilihan utama pada pengobatan DMG karena dapat menyebabkan peningkatan berat badan sedangkan penggunaan metformin lebih banyak digunakan. Kesimpulan dari review ini menunjukan tidak terdapat perbedaan efektivitas dalam penggunaan terapi insulin dan metformin dalam menurunkan kadar gula darah pasien DMG. Penggunaan metformin lebih efisien karena tidak menimbulkan kenaikan berat badan dan mengurangi risiko makrosomia dan neonatal hipoglikemia.
Efek Pemberian Ekstrak Etanol Bunga Rosella (Hibiscus sabdariffa L.) terhadap Inflamasi dan Disfungsi Endotel Kaniawati, Marita; Sulaeman, Agus; Nurfazri, Aulia; Susilawati, Elis; Auliyaa, Millata; Maia de Fatima Freitas, Floriana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.238

Abstract

Obesity can cause enlargement and increase in the number of adipose cells in the body as well as a decrease in adiponectin levels. Adiponectin is an anti-inflammatory cytokine. Obesity is also associated with vascular endothelial dysfunction, which is caused by reduced nitric oxide (NO) availability, as a result of increase production of oxidative stress. This study aims to determine the effect of ethanol extract of rosella flowers (Hibiscus sabdariffa Linn) on adiponectin levels and serum NO levels in animal models of fructose-induced obesity. The research method was using a Post Test Only Control Group Design, using male Wistar rats for 60 days. This study consisted of 6 groups, namely the normal group (normal diet), the induction group (normal diet + fructose 60%), the comparison group (normal diet + fructose 60% + orlistat), and 3 test groups (normal diet + fructose 60% + ethanol extract of rosella flowers 125 mg/ kgBW, 250 mg/kgBW and 500 mg/kgBW). The results show that the ethanol extract of rosella flowers has a reducing effect on body weight and increases serum adiponectin and NO levels. In conclusion, ethanol extract of rosella flowers at a dose of 250 mg/kgBW can increase adiponectin levels and a dose of 500 mg/kgBW is the best dose in improving endothelial dysfunction.
Analisis Likuiditas, Solvabilitas dan Arus Kas Operasi terhadap Financial Distress dengan Komite Audit sebagai Variabel Moderasi Susilawati, Elis; Gurendrawati, Etty; Khairunnisa, Hera
Jurnal Akuntansi, Perpajakan dan Auditing Vol 4 No 1 (2023): Jurnal Akuntansi, Perpajakan dan Auditing
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/japa.0401.11

Abstract

This research was conducted to determine the effect of liquidity, solvency, and operating cash flow on financial distress with the audit committee as a moderating variable. The purposive sampling method was used as a sampling technique with 28 selected companies from all infrastructure companies listed on the Indonesia Stock Exchange for 2020 – 2021. This research uses secondary data obtained by documentation techniques from financial statements, cash flow reports, and company annual reports. The data was processed using panel data regression analysis with the Eviews 12 program. The results of this study indicate that liquidity and operating cash flow have a significant positive effect on financial distress. Meanwhile, solvency does not affect financial distress. Then the audit committee as a moderating variable in this study is unable to moderate the effect of liquidity, operating cash flow, and solvency on financial distress.
Co-Authors Agus Sulaeman Anggreini, Tyas Septiana Auliyaa, Millata Etty Gurendrawati, Etty Khairunnisa, Hera Maia de Fatima Freitas, Floriana Marita Kaniawati Nurfazri, Aulia Sukmawati, ika kurnia