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All Journal MNJ (Malang Neurology Journal) Biomolecular and Health Science Journal Jurnal Keperawatan
Sugondo, Alexander Tikara
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Relationship between HbA1c Levels with eGFR and Blood Pressure in Type 2 Diabetes Mellitus Patients in the Department of Internal Medicine Dr. Soetomo General Hospital Surabaya Sugondo, Alexander Tikara; Ardiany, Deasy; Nuswantoro, Djohar; Notopuro, Pulus Budiono
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.65 KB) | DOI: 10.20473/bhsj.v2i2.14956

Abstract

Introduction: Diabetes mellitus is a non-transmitted pandemic disease which had spreaded on a global scale. The prevalence of diabetes mellitus in the world according to the International Diabetes Federation (IDF) is 1.9% and diabetes mellitus is ranked seventh as the cause of death in the world, around 95% in the world is type 2 diabetes mellitus. According to Riset Kesehatan Dasar (Riskesdas) in 2013, the prevalence of diabetes mellitus in Indonesia is 6,9%. Type 2 diabetes mellitus that is not well controlled will increase the risk of chronic complications, both microangiopathies such as nephropathy, and macroangiopathy such as hypertension. The aim of the study was to determine correlation between HbA1c levels with eGFR (Estimated Glomerulus Filtration Rate) and blood pressure (systolic and diastolic).Methods: An analytic observational cross-sectional study, collecting the data from 94 patients with type 2 diabetes mellitus, Dr. Soetomo General Hospital, Surabaya, from January to May 2018. The variables were collected from patient's medical records. Analysis using Spearman's Rank Correlation test. To determine normality of the data, we use Kolmogorov-smirnov test.Results: The results showed that there are 134 (57,8%) patients with type 2 diabetes mellitus are female more than male. Patients with greater than or equal to 45 years old were 203 (87,5%) patients, more than under 45 years old. The correlation test showed that there was no significant correlation between HbA1c and systolic blood pressure (r=-0,127; p=0,054). Also there was no significant correlation between HbA1c and diastolic blood pressure (r=-0,111; p=0,093). Analysis on other factor showed a significant correlation between HbA1c and eGFR (r=0.341; p=0.000).Conclusion: There was no significant correlation between HbA1c and systolic blood pressure, also there was no significant correlation between HbA1c and diastolic blood pressure. But, there was a significant correlation between HbA1c and eGFR. This is because the data retrieval does not consider the drug consumption and therapy that has been done by the patient, as well as examination of HbA1c, serum creatinine eGFR, and blood pressure not at the same time.
THE SAFETY AND OUTCOME OF ACUTE ISCHAEMIC STROKE PATIENTS WITH COVID-19 TREATED WITH INTRAVENOUS RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR: A SYSTEMATIC REVIEW Machin, Abdulloh; Setjaputra, Vina Lidya; Susianto, Steven Christian; Husni, Nadya; Sugondo, Alexander Tikara
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July 2024
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.12

Abstract

Background: Strokes associated with SARS-CoV-2 may be linked to increased mortality rates. The utilization of intravenous thrombolysis is anticipated to enhance the clinical results in such patients. Moreover, emerging evidence underscores the importance of evaluating the safety and effectiveness of intravenous thrombolysis in individuals suffering from Acute Ischaemic Stroke along with COVID-19. Objective: To assess the safety and effectiveness of intravenous thrombolysis in Acute Ischaemic Stroke patients with COVID-19. Methods: A systematic literature search (Pubmed, Elsevier, and Cochrane database) with keywords (((intravenous thrombolysis) AND (acute ischemic stroke)) AND (covid-19)) AND (outcome))). We selected research studies for evaluation based on specific inclusion and eligibility criteria. Two independent reviewers then proceeded to extract and analyze various data points, including the name of the first author, the year of publication, the study's design, the National Institute of Health Stroke Scale (NIHSS) scores at admission and post-treatment, hospitalization-related mortality, and the occurrence of hemorrhagic transformation. Results: Three studies (n=153 patients) were included, mostly men with advanced age with the most common comorbidity being hypertension. Median of NIHSS Score of subjects on admission is 11, 12, and 13, with interquartile range from 3 to 20 (minor to severe stroke). The mRS at discharge and 1 month after admission is: 0–2 pts in 57 patients, ≥2 in 43 patient. Hemorrhagic transformation involved 3.23% of patients from total samples, death within hospitalization and 1-month mortality were in 23 patients (15%). In numerous studies, there was inadequate data available to determine the precise reason for mortality. Conclusion: Following IV-rTPA therapy, our COVID-19 infection subjects' mRS scores ranged from mild to moderate disability. Fifteen percents of all subjects died, and 3.23% of subjects experienced hemorrhagic transformation. However, majority of our subjects have high median NIHSS scores at admission, advanced age, complicated with baseline risk factors as high blood pressure, diabetes, and hyperlipidemia.
Hubungan Inflammatory Bowel Disease sebagai Risiko terjadinya Penyakit Parkinson Sugondo, Alexander Tikara; Artama, Marvell Aurelinus; Primadana, Aditya; Savitri, Kania Aviandi; Ayunani, Nadia Noorbertha
Jurnal Keperawatan Vol 16 No 2 (2024): Jurnal Keperawatan: Juni 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v16i2.1714

Abstract

Parkinson’s disease (PD) adalah penyakit neurodegeneratif yang menyebabkan gangguan gerakan dengan prevalensi yang diperkirakan akan terus meningkat. Beberapa penelitian menunjukkan bahwa inflammatory bowel disease (IBD) dapat menjadi faktor risiko terjadinya PD. Memaparkan dan menganalisis hubungan antara IBD sebagai faktor risiko terjadinya PD. Penelusuran literatur dilakukan melalui Google Scholar, PubMed, SAGE, JSTOR, ProQuest, dan EBSCOhost, dengan kata kunci “inflammatory bowel disease”, “Parkinson’s disease”, dan “chronic intestinal inflammation”. Kriteria inklusi mencakup literatur orisinil dalam Bahasa Inggris yang meneliti hubungan IBD dengan PD. Pada studi ini didapatkan bahwa ditemukan hubungan antara IBD dan PD. Peningkatan risiko PD pada pasien dengan IBD dapat terkait dengan mekanisme inflamasi, gangguan gut-brain axis, penumpukan protein α-synuclein, dan mutasi gen LRRK2. Terapi antiinflamasi dapat digunakan untuk mencegah terjadinya PD pada pasien IBD. Sebagian besar studi menunjukkan adanya hubungan yang signifikan antara IBD dan PD.
Co-Authors Ardiany, Deasy Artama, Marvell Aurelinus Ayunani, Nadia Noorbertha Husni, Nadya Machin, Abdulloh Notopuro, Pulus Budiono Nuswantoro, Djohar Primadana, Aditya Savitri, Kania Aviandi Setjaputra, Vina Lidya Susianto, Steven Christian