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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Manuntung FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL ILMU KEFARMASIAN INDONESIA Majalah Farmasetika Archives Pharmacia Journal of Food and Pharmaceutical Sciences
Pertiwi, Ratih Dyah
Departement Of Pharmacy, Universitas Esa Unggul, Jalan Arjuna Utara No.9 Kebon Jeruk, West Jakarta 11150
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL LIMBAH KULIT BUAH APEL (Malus domestica Borkh.) TERHADAP RADIKAL BEBAS DPPH (2,2-Diphenyl-1-Picrylhydrazil) Pertiwi, Ratih Dyah; Yari, Cut Ervinar; Putra, Nanda Franata
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.658 KB) | DOI: 10.51352/jim.v2i1.51

Abstract

Recently, many plants have not been utilized properly, one of those is apple plant. There are several types of apples which are widely consumed and used as processed products, among others, as candied apples, syrup and fruit juice. The effluent from the process in the form of processed peel and pulp is not only used as a substitute for animal feed and fertilizer plants, but also used as a natural antioxidant that is needed by the human body against various free radical. Most of the people who like to consume apples prefer to discard the apple peel without using it. Apple peel contains quercetin substances, which needed to increase the levels of antioxidants. The preparation of ethanol extract from apple peels waste is used by maceration method using solvent 70% ethanol. To test the antioxidant activity towards free radical DPPH the extract was made into several concentrations, namely 10 ppm, 20 ppm, 30 ppm, 40 ppm and 60 ppm, and than mixed with a solution of DPPH with concentration of 100 ppm. The absorbance was measured using  a  spectrophotometer  UV-Visible.  Based  on  the  result  of  the  research,  the percentage  of  reduction  obtain  from  those  of  extract  concentrations  were  8.580%, 14.510%, 21.653%, 26.685% and 34,232%. From percentage reduction result, it was obtain IC50 in the amount of 87.795 ppm. Based on the IC50 values can be conclud that the ethanol extract of apple peel waste has strong antioxidant activity classification
UJI AKTIVITAS ANTIBAKTERI FORMULASI GEL UNTUK SARIAWAN DARI EKSTRAK DAUN SAGA ( Abrus precatorius Linn. ) TERHADAP BAKTERI Staphylococcus aureus Pertiwi, Ratih Dyah; Kristanto, Joni; Praptiwi, Graha Ayu
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.591 KB) | DOI: 10.51352/jim.v2i2.72

Abstract

One of plants used by Indonesian people as a traditional medicine is saga plant (Abrus precatorius L.). This plant has medicinal properties as medication for thrush, cough and laryngitis. Chemical constituents contained in sage leaves which work as antibacterial are flavonoid and saponin. This study aims to determine the optimal concentration of saga leaves extract which can be formulated in a gel dosage form with qualified physical evaluation and has antibacterial activity against Staphylococcus aureus. Saga leaves extract is prepared by maceration method using ethanol 70% as solvent, and then the extract obtained is preliminarily tested to see its antibacterial activity against Staphylococcus aureus with agar diffusion method. Gel formulation for thrush is made with dispersion method in three formulas with variants of active substance concentration that is FI (1%), FII (3%) and FIII (5%). Gel preparation antibacterial activity test is conducted with agar diffusion method as a plate cylinder. Based on this research, it was found that the extract of saga leaves which is positively made is efficacious as antibacterial and can be formulated into a gel preparation for thrush with optimal concentration in F III (5%), this is indicated by widest diameter of the inhibition area against Staphylococus aureus bacteria
Radical Scavenging Activity and Quercetin Content of Muntingia calabura,L Leave extracted by Various Ethanol Concentration Pertiwi, Ratih Dyah
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

ABSTRACT Muntingia calaburais broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colourimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated thatMuntingia calaburaleaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent Keywords: DPPH, Muntingia calabura, phenolic total, antiradical activity, TLC densitometry 
Formulasi dan Evaluasi sediaan Balsam Bibir Menggunakan ekstrak Bunga Kembang Sepatu (Hibiscus rose sinensis L ) sebagai Pewarna Alami Pertiwi, Ratih Dyah; Pertiwi, Ratih Dyah
Archives Pharmacia Vol 2, No 2 (2020): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ekstrak bunga Kembang Sepatu (Hibiscus rosa sinensis L) memiliki kandungan senyawa antosianin yang dapat dimanfaatkan sebagai pewarna alami. Salah satu pewarna yang bisa dimanfaatkan adalah pewarna sediaan balsam bibir. Pembuatan ekstrak bunga kembang sepatu menggunakan metode maserasi dengan menggunakan  pelarut etanol 96%. Formulasi sediaan balsam bibir dibuat dengan penambahan pewarna alami dengan menggunakan ekstrak bunga kembang sepatu dengan konsentrasi yang berbeda. Evaluasi sediaan meliputi uji organoleptis, homogenitas, titik lebur , uji stabilitas selama empat minggu penyimpanan pada suhu kamardan uji oles. Hasil formulasi sediaan balsam bibir menggunakan ekstrak bunga kembang sepatu menunjukkan bahwa sediaan yang dibuat homogen, titik lebur antara 51,6 – 53,6˚C, pH 5, dan stabil dalam penyimpanan suhu kamar selama empat minggu.Balsam bibir yang diformulasikan dengan ekstrak bunga kembang sepatu diharapkan dapat digunakan sebagai kosmetik pilihan yang ramah lingkungan dan memiliki efek samping minimal dibandingkan dengan balsam bibir yang beredar di pasaran saat ini.
Formulasi dan Evaluasi sediaan Balsam Bibir Menggunakan ekstrak Bunga Kembang Sepatu (Hibiscus rose sinensis L ) sebagai Pewarna Alami Pertiwi, Ratih Dyah; Pertiwi, Ratih Dyah
Archives Pharmacia Vol 2, No 2 (2020): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ekstrak bunga Kembang Sepatu (Hibiscus rosa sinensis L) memiliki kandungan senyawa antosianin yang dapat dimanfaatkan sebagai pewarna alami. Salah satu pewarna yang bisa dimanfaatkan adalah pewarna sediaan balsam bibir. Pembuatan ekstrak bunga kembang sepatu menggunakan metode maserasi dengan menggunakan  pelarut etanol 96%. Formulasi sediaan balsam bibir dibuat dengan penambahan pewarna alami dengan menggunakan ekstrak bunga kembang sepatu dengan konsentrasi yang berbeda. Evaluasi sediaan meliputi uji organoleptis, homogenitas, titik lebur , uji stabilitas selama empat minggu penyimpanan pada suhu kamardan uji oles. Hasil formulasi sediaan balsam bibir menggunakan ekstrak bunga kembang sepatu menunjukkan bahwa sediaan yang dibuat homogen, titik lebur antara 51,6 – 53,6˚C, pH 5, dan stabil dalam penyimpanan suhu kamar selama empat minggu.Balsam bibir yang diformulasikan dengan ekstrak bunga kembang sepatu diharapkan dapat digunakan sebagai kosmetik pilihan yang ramah lingkungan dan memiliki efek samping minimal dibandingkan dengan balsam bibir yang beredar di pasaran saat ini.
Efektivitas Repelan Losion Minyak Atsiri Daun Zodia (Evodia Suaveolens) Terhadap Nyamuk Aedes aegypti Linnaeus Aprilita Rina Yanti Eff; Ratih Dyah Lestari Ayu Pertiwi; Tyas Putri Utami
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25868

Abstract

Zodia (Evodia suaveolens) merupakan salah satu tanaman yang mempunyai aroma yang tajam pada bagian bunga dan daunnya dan dipercaya dapat mengusir nyamuk. Daun Zodia mengandung minyak atsiri evodiamine dan rutaecarpine yang tidak disukai oleh nyamuk. Tujuan penelitian ini untuk menilai efektivitas repelen losion mengandung minyak atsiri daun Zodia pada konsentrasi 1%, 1.5% dan 2%. Metodenya dengan iosion yang dibuat dengan mencampurkan minyak atsiri hasil isolasi dari daun Zodia pada konsentrasi 1%, 1,5% dan 2% ke dalam formulasi sediaan losion yang terdiri dari asam stearat, setil alkohol, parafin cair, dimetikon, vaselin kuning, trietanolamin dan asam sitrat. Pengujian dilakukan dengan cara memasukkan lengan secara bergantian antara lengan yang diberi perlakuan (losion) dan kontrol (tidak diberi perlakuan) ke dalam kurungan nyamuk yang berisi 25 ekor nyamuk Aedes aegypti, kemudian  dihitung jumlah nyamuk yang hinggap setiap jam selama enam jam. Efikasi repelan ditentukan berdasarkan daya proteksi yang dihitung dengan rumus : Daya proteksi (DP) =( K - R)/K x 100%; K = banyaknya hinggapan pada lengan control; R = banyaknya hinggapan pada lengan pelakuan.  Hasil penelitian losion mengandung minyak atsiri daun zodia pada konsentrasi 1%, 1,5% dan 2% berpotensi sebagai pengusir nyamuk  (repelan) Aedes aegypti dengan daya proteksi rata-rata selama enam jam berturut-turut  adalah sebesar 74,50%, 75,39% dan 82,45%. Tidak terdapat perbedaan yang signifikan pada daya proteksi antara ke 3 konsentrasi losion  (p>0.05) Losion mengandung minyak atsiri daun zodiac pada konsetrasi 1%, 1,5% dan 2% memiliki efektivitas sebagai repelen. Daya proteksi tertinggi ditunjukkan oleh losion yang mengandung minyak atsiri daun Zodia 2% yaitu sebesar 82.45%.
Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Abstract

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.
Pembuatan, Karakterisasi dan Uji In Vitro Nanopartikel Emas Berbasis Konjugat Gom Arab-Vinkristin Ratih Dyah Pertiwi; Joshita Djajadisastra; ABDUL MUTALIB; Anung Pujiyanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.237 KB) | DOI: 10.35814/jifi.v16i1.486

Abstract

Gold nanoparticles (AuNP) are potentially developed as nanomedicine because AuNP is easily synthesized, functionalized, and biocompatible. With gum arabic as a stabilizer, vincristine was conjugated with gold nanoparticles. As a reducing agent, it used 0.02 M Natrium Boro Hidrat (NaBH4) solution. Gold nanoparticles (AuNP) coated with conjugated gum Arabic (GA) and vincristine (VCR) were successfully synthesized and characterized. The conjugation of GA-VCR and AuNP displayed a narrow hydrodynamic particle size distribution with average size < 100 nm by TEM and PSA (particle size analyzer). We investigated the cytotoxic activity of conjugated vincristine-gum arabic-gold nanoparticle by tetrazolium salt assay (MTT) using cancer cell line CCR-CEM. Cytotoxic activity of conjugated VCR-GA-AuNP before and after purification by Size Exclusion Chromatography (SEC), against leukemia cell line CCRF-CEM, was described by IC50 value. All formulation had a cytotoxic of activity with IC50 <20 μg/ml. The IC50 of samples against CCRF cell line were 1,026 μg/mL and 2,607 ug/mL, respectively.
THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR Aprilita Rina Yanti Eff; Erika Noviyanti; Ratih Dyah Pertiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4874

Abstract

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors.  This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.
Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Abstract

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.
Co-Authors ABDUL MUTALIB Anung Pujiyanto Aprilita Rina Yanti Eff Erika Noviyanti Erna Prawita Setyowati JOSHITA DJAJADISASTRA Kristanto, Joni Praptiwi, Graha Ayu Putra, Nanda Franata Ronny Martien Suwaldi . Tyas Putri Utami Yari, Cut Ervinar