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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical Sciences and Research (PSR) EJOIN : Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
Aprilita Rina Yanti Eff
Universitas Esa Unggul
Humanities Chemistry Economics, Econometrics & Finance Education Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Efektivitas Repelan Losion Minyak Atsiri Daun Zodia (Evodia Suaveolens) Terhadap Nyamuk Aedes aegypti Linnaeus Aprilita Rina Yanti Eff; Ratih Dyah Lestari Ayu Pertiwi; Tyas Putri Utami
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25868

Abstract

Zodia (Evodia suaveolens) merupakan salah satu tanaman yang mempunyai aroma yang tajam pada bagian bunga dan daunnya dan dipercaya dapat mengusir nyamuk. Daun Zodia mengandung minyak atsiri evodiamine dan rutaecarpine yang tidak disukai oleh nyamuk. Tujuan penelitian ini untuk menilai efektivitas repelen losion mengandung minyak atsiri daun Zodia pada konsentrasi 1%, 1.5% dan 2%. Metodenya dengan iosion yang dibuat dengan mencampurkan minyak atsiri hasil isolasi dari daun Zodia pada konsentrasi 1%, 1,5% dan 2% ke dalam formulasi sediaan losion yang terdiri dari asam stearat, setil alkohol, parafin cair, dimetikon, vaselin kuning, trietanolamin dan asam sitrat. Pengujian dilakukan dengan cara memasukkan lengan secara bergantian antara lengan yang diberi perlakuan (losion) dan kontrol (tidak diberi perlakuan) ke dalam kurungan nyamuk yang berisi 25 ekor nyamuk Aedes aegypti, kemudian  dihitung jumlah nyamuk yang hinggap setiap jam selama enam jam. Efikasi repelan ditentukan berdasarkan daya proteksi yang dihitung dengan rumus : Daya proteksi (DP) =( K - R)/K x 100%; K = banyaknya hinggapan pada lengan control; R = banyaknya hinggapan pada lengan pelakuan.  Hasil penelitian losion mengandung minyak atsiri daun zodia pada konsentrasi 1%, 1,5% dan 2% berpotensi sebagai pengusir nyamuk  (repelan) Aedes aegypti dengan daya proteksi rata-rata selama enam jam berturut-turut  adalah sebesar 74,50%, 75,39% dan 82,45%. Tidak terdapat perbedaan yang signifikan pada daya proteksi antara ke 3 konsentrasi losion  (p>0.05) Losion mengandung minyak atsiri daun zodiac pada konsetrasi 1%, 1,5% dan 2% memiliki efektivitas sebagai repelen. Daya proteksi tertinggi ditunjukkan oleh losion yang mengandung minyak atsiri daun Zodia 2% yaitu sebesar 82.45%.
THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR Aprilita Rina Yanti Eff; Erika Noviyanti; Ratih Dyah Pertiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4874

Abstract

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors.  This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.
Upaya Pencegahan Penyakit Sindrom Metabolik Sejak Remaja Aprilita Rina Yanti Eff; Sri Teguh Rahayu; Ayu Puspita Lena
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 3 (2022): JPMI - Juni 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.612

Abstract

Masa remaja merupakan fase kritis dimana terjadi beberapa perubahan, seperti perubahan fisik, perkembangan otak, maturasi organ seksual, dan perkembangan psikososial yang mempengaruhi perilaku terkait kesehatan. Remaja rentan mengalami permasalahan kesehatan, terutama pada penyakit sindrom metabolik. Hal ini juga didukung apabila gaya hidup masa remaja tidak diperhatikan terutama di masa pandemi seperti sekarang ini, dimana makan yang tidak terkontrol dan jarang melakukan aktivitas fisik sehingga penyakit sindrom metabolik ini semakin rentan terjadi pada usia remaja. Kegiatan Pengabdian Masyarakat dilakukan dengan memberikan edukasi mengenai sindrom metabolik pada 30 siswa siswi kelas IX SMP 264 Jakarat berupa pemberian materi mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur, agar dapat diterapkan dalam kehidupan sehari-hari.  Selain itu dilakukan pula pengukuran berat badan, tinggi badan, tekanan darah, dan lingkar pinggang untuk melihat gambaran kesehatan siswa-siswi SMPN 264 Jakarta. Hasil pengukuran tekanan darah menunjukkan 5 orang siswa memiliki tekanan darah ?130/85 mmHg. Pemberian Edukasi pada 30 siswa siswi kelas IX SMPN 264 Jakarta mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur   sangat penting untuk terus dilakukan sehingga remaja memiliki pengetahuan tentang pentingnya menerapkan pola hidup sehat untuk mencegah sindrom metabolik.
Uji Efek Antiinflamasi Fraksi Air Daun Mahkota Dewa (Phaleria macrocarpa (Shecff.) Boerl.) terhadap Tikus Putih (Rattus norvegicus L.) Eff, Aprilita Rina Yanti; Dewanti, Ema; Adelina H, Melisha
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Inflammation occurs as the attempt of body to inactivate organisms that attack the body, removing irritants and regulate tissue repair. One of the medicinal plants used empirically as antiinflammation is the leaf of Mahkota Dewa (Phaleria macrocarpa (Schecff.) Boerl). This study investigated the effect of anti-inflammatory water fraction of leaf Mahkota Dewa using oedema induction method with caragenin in rat. Water fraction of Mahkota Dewa was given at the dose 0.5 g/kg BW ,1 g/kg BW and 2 g/kg BW. Sodium diclofenac was used as a positive control and CMC as negative control. The result showed water fractions of three doses can inhibit inflammation at 27.35%, 18.58%, and 20.17%, respectively. The water fraction at the dose 0.5 g/kgBW showed the largest percentage of oedema inhibition compared to other treatment groups.
Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Eff, Aprilita Rina Yanti; Ayu Pertiwi, Reza; Ehe Hurit, Hermanus; Rahayu, Sri Teguh; Eden, Yonatan
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.
FUN AEROBIC DAN EDUKASI KESEHATAN MENGENAI AKTIVITAS FISIK DAN KONSUMSI MAKANAN BERGIZI DI SD LAZUARDI CORDOVA GCS, JAKARTA BARAT Intan Silviana Mustikawati; Mury Kuswari; Rachmanida Nuzrina; Rian Adi Pamungkas; Ernalinda Rosya; Aprilita Rina Yanti Eff; Sri Teguh Rahayu
EJOIN : Jurnal Pengabdian Masyarakat Vol. 2 No. 2 (2024): EJOIN : Jurnal Pengabdian Masyarakat, Februari 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v2i2.2233

Abstract

One of the problems of school-age children is a change in lifestyle from traditional life style to sedentary life style which is the cause of lack of physical activity that can increase the risk of obesity. The practice of regular physical activity is very important to improve body health which can have an impact on student achievement. Communication, information, and education among students about the importance of practicing regular physical activity are needed to improve knowledge, attitudes, and practices of physical activity. The purpose of this activity is to provide health education about physical activity and consumption of nutritious food, practice aerobic gymnastics together, and health examinations and consultations. The targets of this activity are students, parents, teachers, and employees of SD Lazuardi Cordova GCS, West Jakarta. These activities were carried out in the form of health education through lectures and discussions, practice aerobic gymnastics together, health checks such as height, weight, blood pressure, nutritional status, blood sugar, and uric acid, as well as health consultations. Regular health education in schools is needed to improve health knowledge, attitudes, and practices in students.
Assessment of Drug Therapy Problems Among Type 2 Diabetes Patients with Hypertension Comorbidity in Indonesia Julaeha Julaeha; Ery Fudjiati; Aprilita Rina Yanti Eff
Borneo Journal of Pharmacy Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i3.1359

Abstract

Type 2 diabetes mellitus (T2DM) is a major chronic disease that affects a large number of people worldwide. Hypertension is a common disease comorbidity among T2DM patients, and often those patients received polypharmacy and complex treatment in long term duration. This condition may lead to an increased risk of drug therapy problems (DTPs). This study aimed to assess and determine potential drug therapy problems in type 2 diabetic patients with hypertension comorbidity. Retrospective cross-sectional design was conducted in a hospital setting, especially data sources from the prescription of ambulatory T2DM patients with hypertension. A total of 190 patients were studied. More than half of the participants were female (53.68%). The majority age range of participants was 50-59 years (46.84%). Almost all antidiabetic agents were prescribed as polypharmacy (73.16%). Metformin was the most antidiabetic agent prescribed as monotherapy and combination therapy (63.16%). Almost all antihypertensive agents were prescribed as polypharmacy (63.26%). Amlodipine was the most antihypertensive agent prescribed as monotherapy and combination therapy (34.74%). Among the study participants, 56.84% have at least one of DTPs. Adverse drug reaction was the most frequent (47.22%), followed by ineffective drug therapy (29.63%). Since the potential of DTPs in T2DM patients with hypertension comorbidity is relatively high, early identifying, resolving, and preventing drug therapy problems by the pharmacist is needed to achieve goals of treatment.
Co-Authors Adelina H, Melisha Ayu Pertiwi, Reza Ayu Puspita Lena Eden, Yonatan Ehe Hurit, Hermanus Ema Dewanti Erika Noviyanti Ernalinda Rosya Ery Fudjiati Intan Silviana Mustikawati Julaeha Julaeha Mury Kuswari Pertiwi, Ratih Dyah Rachmanida Nuzrina Rian Adi Pamungkas Sri Teguh Rahayu Sri Teguh Rahayu, Sri Teguh Tyas Putri Utami