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All Journal Jurnal Ilmu Kesehatan Duta Gama Klaten Jurnal Ilmu Kesehatan Bhakti Setya Medika
Dellima, Beta Ria Erika Marita
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Health Professions Medicine & Pharmacology Nursing Public Health

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FORMULATION SALEP FENNEL LEAVES EXTRAC (Feoniculum vulgare Mill) WITH SALEP HIDROKARBON BASE VARIATION (VASELIN ALBUM) AND WATER BASE (PEG 6000) ON Staphylococcus aureus Riris Nurul Hidayah; Beta Ria Erika Marita Dellima; Mitta Aninjaya
STIKES DUTAGAMA KLATEN Vol 9 No 2 (2017): JURNAL ILMU KESEHATAN STIKES DUTA GAMA KLATEN
Publisher : STIKES DUTAGAMA KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5737/v9i2.310

Abstract

Background: Fennel leaves (Feoniculum vulgare Mill) has potential as a medicine. The content of polyphenols, saponins, essential oils, and flavonoids found in the leaves show antibacterial effects. Fennel leaf extract is more perfect when formulated in ointment form. The use of ointment may allow direct contact with the skin. Objective: The objective of this research was to know the antibacterial activity and physical characteristic of fennel leaves extract (Feoniculum vulgare Mill) as inhibitor of Staphylococcus aureus. Research Method: This research is an experimental research by using One Group Pretest Posttest method. Fennel leaf extract (Feoniculum vulgare Mill) was obtained by maceration for 5 days. Furthermore fennel leaf extract identified active compounds contained therein. Then fennel leaf extract at concentrations of 20%, 25%, 30%, 35%, and 40% were tested for antibacterial activity of Staphylococcus aureus. Fennel leaf extract of 40% concentration is formulated in an ointment preparation with a hydrocarbon base (vaseline album) and water soluble base (PEG 6000). Testing of antibacterial activity using Staphylococcus aureus and physical properties of ointment. Testing of antibacterial activity using Staphylococcus aureus with agar diffusion method with sunuran technique, while for Tests physical properties of ointment include organoleptic test, homogeneity test, scattering, adhesion, power protection test, pH test. The data obtained were analyzed by Anova test statistic and Kruskal Wallis test. Result: The result of identification of active compound of fennel leaf extract have flavonoids, polyphenols, saponins. The base salt of hydrocarbon (vaseline album) and water soluble base (PEG 6000) showed that the spread of both ointment base did not show any significant difference and adhesion showed significant difference. The antibacterial activity of the hydrocarbon base ointment (vaseline album) and the water soluble base (PEG 6000) has a significant difference. Conclusion: The base used in this study has an effect on the physical quality of fennel leaf extract. This is seen from the scattering power value and the attachment power of both formulations. An ointment preparation with a hydrocarbon base (vaseline album) and a water soluble base (PEG 6000) affects the effectiveness of antibacterial ointment.
FORMULASI DAN EVALUASI SEDIAAN GEL INFUSA DAUN KELOR (Moringa oleifera Lam.) Beta Ria Erika Marita Dellima
JURNAL ILMU KESEHATAN BHAKTI SETYA MEDIKA Vol. 7 No. 1 (2022): Jurnal Ilmu Kesehatan Bhakti Setya Medika
Publisher : Politeknik Kesehatan Bhakti Setya Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.839 KB) | DOI: 10.56727/bsm.v7i1.79

Abstract

Kelor (Moringa oleifera Lam.) merupakan tanaman yang mempunyai banyak manfaat. Pemanfaata tanaman kelor menjadi bentuk sediaan farmasetis dapat memaksimalkan pemanfaatan daun kelor. Gel merupakan bentuk sediaan semi padat yang dapat diaplikasikan pada kulit. Sifat fisik sediaan gel dipengaruhi oleh eksipien (bahan tambahan dalam formulasi). Salah satu eksipien yang dapat mempengaruhi sifat fisik sediaan gel adalah gelling agent. Penggunaan HPMC sebagai gelling agent dapat menghasilkan cairan yang lebih jernih, netral, tidak berwarna, tidak berasa, menghasilkan gel dengan viskositas yang baik dalam penyimpanan jangka lama, tidak beracun dan tidak mengiritasi kulit. Daun kelor diekstraksi menggunakan metode infundasi. Infusa daun kelor diidentifikasi kandungan fitokimianya. Infusa daun kelor diformulasikan dengan HPMC sebagai gelling agent dalam berbagai konsentrasi 2,5 %, 5% dan 7,5% membentuk sediaan gel. Gel yang dihasilkan kemudian dievaluasi sifat fisik sediaan yang meliputi : uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji daya lekat, yang dibandingkan dengan nilai standar parameter fisik sediaan gel. Hasil penelitian menunjukkan bahwa infusa daun kelor mengandung senyawa fitokimia : vitamin C, alkaloid, triterpenoid, saponin dan polifenol. Dari ketiga formula gel infusa daun kelor, formula II dengan konsentrasi gelling agent HPMC 5% memberikan hasil paling baik dan memenuhi nilai standar parameter fisik sediaan gel. Kata kunci : daun kelor, infusa, gelling agent
Co-Authors Mitta Aninjaya Riris Nurul Hidayah