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All Journal Jurnal Kedokteran Mutiara Medika: Jurnal Kedokteran dan Kesehatan
priyambodo, seto
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Health Professions Medicine & Pharmacology

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Asam lemak heptadekanoat sebagai diet fungsional pada Diabetes Mellitus tipe 2 priyambodo, seto; Kusuma Putra, Lalu Shalya; Fathonah, Agi Tri; Courie, Rifqie Fathiarsya; Annisa; Novita Wulandari; I Wayan Manacika
Jurnal Kedokteran Vol 8 No 4 (2019)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v8i4.344

Abstract

Penelitian menunjukkan bahwa fraksi plasma odd chain fatty acid/OCFA (Heptadekanoat/Margaric acid/C17) berbanding terbalik terhadap kejadian penyakit DM tipe 2, resistensi insulin serta kejadian sindrom metabolik.Asam lemak ini merupakan penanda untuk konsumsi dairy fat dan serat makanan, selain itu juga mempunyai peranan metabolik yang penting.Stephanie et al.dalam penelitiannya menemukan bahwa asam lemak heptadekanoat dapat memperbaiki kondisi sindrom metabolik dan mengemukakan hipotesis bahwa menjauhnya manusia dari diet dengan kandungan asam lemak heptadekanoat (termasuk lemak dalam susu) dapat menjadi kontributor meningkatnya kondisi inflamatif serta rendahnya kandungan plasma asam lemak heptadekanoat dalam populasi. Asam lemak heptadekanoat terlibat dalam regulasi metabolismeshort chain,medium chain dan very long chain fatty acid yang lain. Asam lemak ini dapat diubah menjadi propionyl-CoA yang dapat digunakan sebagai penyedia substrat untuk masuk ke dalam siklus asam sitrat melalui jalur succinyl-CoA (reaksi anaplerotik), dengan demikian dapat memperbaiki metabolisme energi mitokondria. Seiring dengan penuaan/aging dan stres metabolik oksidatif fungsi mitokondria mengalami penurunan sehingga ketersediaan senyawa antara anaplerotik untuk siklus asam sitrat dapat membantu optimalisasi mitokondria.
Intoxication Of Mercury: Risk Factors, Pathophysiology And Its Impact For Pregnant Women In The Artisanal And Small Scale Gold Mining Ekawanti, Ardiana; Priyambodo, Seto
Jurnal Kedokteran Vol 9 No 2 (2020): Jurnal Kedokteran Vol 9 No 2 2020 (Edisi Juni 2020)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i2.418

Abstract

Mercury exposure of pregnant women comes from various sources including pollution from gold mining, from the consumption of fish and equipment in the neighborhood where they live. Intoxication that occurs as a result of exposure is determined by the type of mercury, route, dose, duration of exposure and age of the host. Mercury exposure in a pregnant woman not only causes intoxication for her but also affects the fetus . The fetus is a developmental phase that is very susceptible to mercury exposure of all kinds from its mother. Various effects that can arise from this exposure on the fetus include stillbirth, low birth weight and congenital abnormalities.
The Correlation between Lymphocyte Platelet Ratio and Gensini Score in Coronary Heart Disease Patients Muliana, Muliana; Rahmat, Basuki; Priyambodo, Seto
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200136

Abstract

The lymphocyte platelet ratio (LPR) is an inflammatory marker that can be used to identify the severity of coronary heart disease (CHD). This study aims to determine the correlation between the lymphocyte platelet ratio and Gensini scores in CHD patients. This research used correlative analytical research with a cross-sectional design. The sample was selected by consecutive sampling technique and obtained 51 respondents. The calculation of the LPR was carried out by dividing the number of platelets and lymphocytes in the volume unit of 103/mm3. Meanwhile, the Gensini score assessment was carried out by multiplying the percentage of blockages and location of blockages based on the result of coronary angiography. Based on the Gensini score, the sample in this study was classified as mild atherosclerosis with the Gensini score 25 points, and severe atherosclerosis with the Gensini score ≥25 points. The data were analyzed using the Pearson correlation test. The result showed that the average LPR value in samples with severe atherosclerosis was 124.6  and  115.3 in mild atherosclerosis. Based on the result of statistical analysis using the Pearson test, the p-value was 0.107. It can be concluded that there is no significant correlation between the lymphocyte platelet ratio and Gensini scores in CHD patients.
Co-Authors Annisa Ardiana Ekawanti Courie, Rifqie Fathiarsya Fathonah, Agi Tri I Wayan Manacika Kusuma Putra, Lalu Shalya Laksono Trisnantoro Muliana, Muliana Novita Wulandari