The emergence of internet technology has created online advertising as the significant approach of commercial communication all over the world. Advertising has been defined as any paid form of non-personal communication of ideas and information about products in the media with the objective of creating brand image. The development of e-commerce in Indonesia has mushroomed based on MMX Multi-Platform on 2017 showed top 10 e-Commerce in Indonesia. The aim of this study is to analyze the difference of e-Advertisement between 2 big e-Commerce in Indonesia which are Tokopedia and Shopee. This research is a quantitative research and uses independent sample t-test. The sample size of this research is 100 customers of both e-Commerce. The results showed that there are 3 variables that there is no significant difference in e-Advertisement between Tokopedia and Shopee, and the rest were has a significant differences, by referring to the results of observations of online advertising between Tokopedia and Shopee, it was found that there is no difference, so the two big e-commerce companies should maximize their online marketing by determining the right segmentation. so that the direction of marketing is more measurable. Keywords: e-Advertisement, independent sample t-test, website design effectiveness, website security and privacy effectiveness, of information quality, brand recognition, demography.