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All Journal Buletin Farmatera JURNAL FARMASIMED (JFM) Sumatera Medical Journal
Sari, Mutiara Indah
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Immunology & microbiology Medicine & Pharmacology

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The Correlation Between Body Mass Index And Acne Vulgaris Raditra, Ghinia Zati Hulwani; Sari, Mutiara Indah
Sumatera Medical Journal Vol. 3 No. 1 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i1.3557

Abstract

Skin diseases for teenagers and young adults are acne vulgaris. It occurs through various factors, such as food and obesity. Foods with a high glycemic index (IG) are associated with a high incidence of acne vulgaris. By considering the Body Mass Index, the glycemic load has a significant relationship with the occurrence of acne vulgaris. The relationship between BMI and acne vulgaris in the class of 2016 FK USU student population. This study was analytic design with cross sectional design, a sample by 2016 FK USU students. Data collected by conducting a physical examination, measurement of height, weight, determination of BMI, and nutrient intake using the Food Frequency Questioner (FFQ) questionnaire. Data is collected using SPSS program. Then, a Chi-Square test was performed. The incidence of acne vulgaris in students 2016 FK USU was 46.1%. With majority of locations arising acne vulgaris is in the face of 35.6%. The most common age suffering from acne vulgaris is 21 years (22.2%). Women (30.6%) from acne vulgaris than men (15.6%). The most BMI in the sample is underweight to normal body weight (31.7%). The results of data analysis, found no relationship between BMI and acne vulgaris p = 0.336
EFEK EKSTRAK DAUN GAMBIR ( UNCARIA GAMBIR ROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI SIRTUIN 3 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN YANG DIINDUKSI D-GALAKTOSA Sinaga, Inda MH; Sari, Mutiara Indah; Ichwan, Muhammad MH
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.473

Abstract

The aging process must be experienced by all living things, there will be a decrease in the tissue ability to maintain its function so that pathological conditions occur. Some things can cause aging, Free radical factors are external and internal factors that can trigger aging. Induce of d-galactose continuously one of the factors that can increase oxidative stress. This study was design to evaluate the effect of gambir leaf extract on oxidative stress and expression of the sirtuin 3 gene in the hippocampus of female mice induced intraperitoneally by d-galactose 150 mg/kgbb. Researchers conducted a post test only control group study with a sample of 24 female mice aged 10 - 12 weeks with the inclusion criteria an average body weight of 25-35 grams, obtained from the same breeding place, maintained at the same place and time and never as research material. Mice were divided into 4 groups with 6 mice each , group (C) female mice induced only d-galactose 150 mg / kg and in sonde aquabidest 0,1%/body weight, mice induced by d-galactose and sonde gambir leaf extract at a dose of 100 mg / kg bw group (C1), group (C2) 200 mg/kgbw, and 400 mg/kgbw group (C3). Blood samples were collected to determine the increase in oxidative stress levels of malondealdehyde (MDA) through spectrophotometry, and hippocampal tissue collected for PCR method so that the expression of the sirtuin 3 gene can be seen. Increased levels of MDA are associated with increased oxidative stress. This study reported the results of MDA levels were not significant ( p value <0.05). The results of the PCR reported an increase in expression 2 times higher than the control at a dose of gambier leaf extract 200 mg / kgbw Keywords:D-Galactose, Malondealdehid,Sirtuin 3,Cathechin.
EFEK EKSTRAK DAUN GAMBIR ( UNCARIAGAMBIRROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI BRAIN DERIVED NEUROTHROPIC FACTOR(BDNF) PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAANYANG DIINDUKSI D-GALAKTOSA Sebayang, Julenda Irianti; Sari, Mutiara Indah; Ichwan, Muhammad Indah
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.475

Abstract

Prevalence of premature aging that causes in decreased memory throughout the world of individuals aged 60 years and over is estimated at 5-7%. According to WHO this is caused by progressive dysfunction and neuronal cell death and is related to free radical formation. This study was design to evaluate the effect of gambir leaf extract ( uncariaGambirRocb ) on MDA and expression BDNF in the hippocampus of aging female mice that are induced in D-Galactose. In this study that method is used a post test only control group, the researcher design with 4 groups being treated ( group1 : inject D-Galactose 150 mg/kgbb/ip and sondeaquabidest 0,1%, group 2 : sondecathechins 100 mg and inject D-Galactose 150mg/kgbb, group 3 ; sondecathechins 200 mg and inject D-Galactose 150 mg/kgbb, group 4 : sondecathechine 400 mg and inject D-Galactose150 mg/kgbb) with the inclusion criteria : all female mice (MusMusculus L) were 10-12 weeks old and had not been studied. MDA is examined through blood serum with spektrofotometer. Isolation RNA with Kit Tiangen Kat DP419 and BDNF expression from the hippocampus by RT PCR Increased level of MDA showed increased stress oksidatif. This study the result of MDA levels were not significant ( p value <0.05 ). There was an increase in BDNF expression in the K2 group compared to the other group in the Control, but it was not significant. The dose of 200 mg/kgbb is determine as the most effective dose of gambier beverage to improve the memory of female mice.
Correlation of 25 Hydroxyvitamin D3 Levels with Blood Pressure and Lipid Profile, in Healthy Individuals Sari, Mutiara Indah; Sanny, Sanny
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6892

Abstract

Vitamin D is a prohormone and its level correlated with several cardiovascular diseases (CVD) biomarker such as blood pressure (systolic and diastolic) and lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). This study aim to analyze correlation of serum 25-hydroxyvitamin D/ 25(OH)D levels with blood pressure and lipid profile in healthy subjects. This cross-sectional study was conducted on 39 healthy subjects from gym in Medan city. Measurement of vitamin D levels using Enzyme Linked Immunosorbent Assay (ELISA). Blood pressure was measured twice after 10 minutes rest using mercury sphygmomanometer. Lipid profile were measured by Cobas 6000 (C510+E610). Correlation of 25(OH)D with blood pressure and lipid profile were analyzed using Spearman correlation test. There was a significant correlation between of 25(OH)D levels and diastolic blood pressure (p = 0.047, r = -0.272), but not in systolic blood pressure and the lipid profile: TC, TG, HDL, and LDL, respectively. (p = 0.159, p = 0.290, p = 0.425, p = 0.492, p = 0.156). This study concluded that 25(OH)D levels was correlated with diastolic blood pressure with low correlation, in that decreasing of 25-hydroxyvitamin D levels will increased diastolic blood pressure.
Co-Authors Ichwan, Muhammad Indah Ichwan, Muhammad MH Raditra, Ghinia Zati Hulwani Sanny Sanny Sebayang, Julenda Irianti Sinaga, Inda MH