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All Journal Buletin Farmatera Narra J Indonesian Journal of Life Sciences
Sanny Sanny
Jurusan Teknologi Pangan, Fakultas Sains dan Teknologi Universitas Pelita Harapan Jl. UPH Tower, Lippo Karawaci, Tangerang 15811
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation of 25 Hydroxyvitamin D3 Levels with Blood Pressure and Lipid Profile, in Healthy Individuals Sari, Mutiara Indah; Sanny, Sanny
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6892

Abstract

Vitamin D is a prohormone and its level correlated with several cardiovascular diseases (CVD) biomarker such as blood pressure (systolic and diastolic) and lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). This study aim to analyze correlation of serum 25-hydroxyvitamin D/ 25(OH)D levels with blood pressure and lipid profile in healthy subjects. This cross-sectional study was conducted on 39 healthy subjects from gym in Medan city. Measurement of vitamin D levels using Enzyme Linked Immunosorbent Assay (ELISA). Blood pressure was measured twice after 10 minutes rest using mercury sphygmomanometer. Lipid profile were measured by Cobas 6000 (C510+E610). Correlation of 25(OH)D with blood pressure and lipid profile were analyzed using Spearman correlation test. There was a significant correlation between of 25(OH)D levels and diastolic blood pressure (p = 0.047, r = -0.272), but not in systolic blood pressure and the lipid profile: TC, TG, HDL, and LDL, respectively. (p = 0.159, p = 0.290, p = 0.425, p = 0.492, p = 0.156). This study concluded that 25(OH)D levels was correlated with diastolic blood pressure with low correlation, in that decreasing of 25-hydroxyvitamin D levels will increased diastolic blood pressure.
Molecular Biomarkers and Pathophysiology Specific to Bipolar Disorder Salim, Megan Angelita; Abriana, Felicia Michelle; Tirta, Matthew Aurelius; Sanny, Sanny; Kristiani, Lidya
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.173

Abstract

Bipolar disorder (BD) is an episodic neuropsychiatric disorder with fluctuations between manic and depressive phases according to their types (BDI/BDII/cyclothymic), contributing to the decreased quality of life due to the impairment of cognitive abilities. Early detection is needed for proper treatment, however, the gold standard Structured Clinical Interview for DSM-IV results in misdiagnosis due to its inability to distinguish BD from other neuropsychiatric disorders. Therefore, diagnosis through molecular biomarkers can be performed to accurately distinguish BD from other neuropsychiatric disorders. This review aims to elaborate the evidence of molecular biomarkers in BD patients from recent studies, which may be fundamental in clinical practices for accurate diagnosis. Proteomic studies provide evidence for the differentially expressed proteins, namely brain-derived neurotrophic factors, which can differentiate BD from major depressive disorder and schizophrenia. Moreover, genetic alterations from genomic and transcriptomic studies found that CACNA1C, ANK3, FADS2, and other genes may predispose an individual to BD. Some of these genes are closely related to BD pathophysiology occurrence, including impaired oxidative phosphorylation, imbalance in calcium homeostasis, and neuroinflammation, all of which arise due to mitochondrial dysfunction. These pathophysiology can be alleviated by proper administration of mood stabilizers, antipsychotics, and anticonvulsants, but novel treatments targeting specific pathophysiology and biomarkers of BD are required for better treatment effectiveness. Keywords: Bipolar disorder; mania/depression; molecular biomarker; mitochondrial dysfunction; pharmacotherapies
Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in diagnosing neonatal sepsis Hasibuan, Beby S.; Dasatjipta, Guslihan; Lubis, Bugis M.; Sanny, Sanny
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.763

Abstract

Clinical manifestations of neonatal sepsis are often unspecified. Therefore, sepsis biomarkers could be used to support diagnosis while waiting for blood culture results, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). The aim of this study was to evaluate the role of NLR and PLR as diagnostic markers in neonatal sepsis. A cross-sectional study was conducted at Haji Adam Malik General Hospital, Medan, Indonesia, from April to October 2019. This study included neonates aged less than 28 days, diagnosed with suspected sepsis, and had no previous history of antibiotics administration. Patients underwent clinical assessment, laboratory examination, and blood culture. Patients were grouped into sepsis and non-sepsis based on the blood culture results. The median hematological examination and the range of NLR and PLR in both the sepsis and non-sepsis groups were subjected to analysis using the Mann-Whitney U test to assess differences. NLR and PLR optimal cut-off values were determined using a receiver operator curve (ROC) with a confidence interval of 95%. A total of 137 neonates were enrolled, of which 49 were classified as sepsis and 89 as non-sepsis based on blood culture results. The optimal cutoff values for NLR and PLR were 2.75 and 11.73. Using those cutoff values, NLR and PLR could predict neonatal sepsis with sensitivities of 52.1% and 47.9%, specificities of 50.6% and 47.2%, area under the curve (AUC) of 0.46 and 0.47, with p=0.525 and p=0.662, respectively. Further investigation is warranted to refine the NLR and PLR utility and enhance diagnostic accuracy in clinical practices.
Co-Authors Abriana, Felicia Michelle Beby S. Hasibuan, Beby S. Bugis M. Lubis, Bugis M. Dasatjipta, Guslihan Kristiani, Lidya Salim, Megan Angelita Sari, Mutiara Indah Tirta, Matthew Aurelius