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All Journal International Journal of Nasopharyngeal Carcinoma The Journal of Society Medicine (JSOCMED)
Daulay, Elvita Rahmi
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : International Journal of Nasopharyngeal Carcinoma

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CORRELATION OF TNF-Α EXPRESSION TO CLINICAL STADIUM IN NASOPHARYNGEAL CARCINOMA Susilo, Riko; Farhat; Asnir, Rizalina A; Yudhistira, Ashri; Daulay, Elvita Rahmi; Chrestella, Jessy
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3503

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia with over 13.000 new cases reported yearly, especially in the male. The TNF-? serum is reported as a new biomarker to predict bone invasion, post-therapy distant metastasis, and poor life sustainability in NPC. Objective: To identify the expression of TNF-? in regards to the clinical stage of NPC. Material and methods: This is an analytic study with 126 NPC samples of patients in Haji Adam Malik General Hospital. Results: NPC mostly found in age group 41-60 years (57.1%), male (71.4%),non-keratinizing SCC (79.4%), and stage IV group (54.8%). In immunohistochemistry evaluation, most of TNF-? overexpressed in non-keratinizing SCC(68.0%), T3-T4 (50.8%), N2-N3 (62.7%) and clinical stage III-IV (69.9%). Spearman's test for categorical correlation yield a p-value of <0,001. Conclusion: There is a significant correlation between TNF-? expression and the stage of NPC.
Co-Authors Ade Irma Akbar, Fariz Nugraha Asnir, Rizalina A Assania, Rizka Farahin Asysyarif, Abdurrahman Chrestella, Jessy Farhat Harry, M. Randy Imansyah, Ade Nur Lubis, Anggia Chairuddin Refli Hasan Ritarwan, Kiking Surbakti, Khairul Putra Susilo, Riko Suzy Indharty Tarigan, Radar Radius Taufik Sungkar, Taufik Yudhistira, Ashri Zamzami, Muhammad Avicienna