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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Journal of Telenursing (JOTING) Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Taufik Sungkar, Taufik
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Vascular endothelial growth factor (VEGF) serum levelsof patients with Helicobacter pylori gastritis with cytotoxin-associated gene A positive (CagA+)status Siregar, Wira Prihatin; Siregar, Gontar Alamsyah; Sungkar, Taufik
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.102 KB) | DOI: 10.19106/JMedSci005104201907

Abstract

Helicobacter pylori (H.pylori) is an agent that causes gastritis and the ulcer of gaster, which are ultimately caused gastric tumors. The prevalence is about 80 % average in developing country and 20-50 % in developed countries. One of the virulence factor iscytotoxin-associated gene A (CagA) that plays a role in the inflammation process,cell proliferation and metaplasia in gastric mucosa. Vascular endothelial growth factor (VEGF)is one of angiogenic factors that plays a role in the process of making new mucosal tissue after the inflammation by H.pylori. The escalation of VEGF expression levels contribute to the beginning of gastric carcinogenesis. The studywas aimed to analyze of VEGF serum levels between CagA(+) and CagA(-) in patients with H.pylori gastritis. Cross sectional study was conducted on 30 patients with H.pylori gastritis after conducted gastroscopy,biopsy and CLO test, which were continued with VEGF serum examination using ELISA test and perfomed PCR test to determinethe CagA status.The data was analyzed with SPSS 22 version andp value <0.05 was considered significant.The results of this study were18 men (60 %) and 12 women (46%) from 30 total subjects, with a median age average was 53.5 years old.Majority ethnic was Batak with 16 subjects (53.3%). Helicobacterpylori gastritis with CagA(+) was about 21 subjects (70%) and H.pylori gastritis with CagA(-) was about 9 subjects (30%). We found that median VEGF serum levels of patients with H.pylori gastritis with CagA(+)[480.3 pg/dL (115.5-2185.2)] significantly higher compared to thatwith CagA(-) [291.1 pg/dL (158.4-556.7)] (p<0.05).In conclusion, the VEGF serum levels ofpatients withH.pylori gastritis with CagA(+) is higher compared to that withCagA(-).
Perbedaan Kadar Pentraxin 3 pada Penderita Hepatitis B Kronis dengan Cirrosis dan Tanpa Cirrosis Sasmita, Afrianda Wira; Sungkar, Taufik; Loesnihari, Ricke
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7252

Abstract

This study aims to see differences in pentraxin 3 levels in chronic hepatitis B sufferers with cirrosis and without cirrosis. The method uses cross sectional consecutive sampling. The results of this study found a significant difference between the average value of Pentraxin 3 in chronic Hepatitis B patients with liver cirrhosis group compared to the group without liver cirrhosis (p<0.001). There was a significant difference between the Pentraxin 3 levels in the group of Chronic Hepatitis B sufferers with liver cirrhosis compared to the group of Chronic Hepatitis B sufferers without liver cirrhosis (p<0.001) where the Pentraxin 3 levels in the Chronic Hepatitis B group with liver cirrhosis were higher compared to the group without liver cirrhosis. In conclusion, Pentraxin 3 levels can be used as an alternative marker to assess the development of liver cirrhosis in Chronic Hepatitis B patients. Keywords: Chronic Hepatitis B, Liver cirrhosis, Pentraxin 3
Correlation of Fatty Liver Imaging on Abdominal CT-Scan with Dyslipidemia in Haji Adam Malik General Hospital in 2020 Akbar, Fariz Nugraha; Daulay, Elvita Rahmi; Sungkar, Taufik
Journal of Society Medicine Vol. 2 No. 5 (2023): May
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i5.51

Abstract

Background: Fatty liver is a broad term for a condition in which there is an increase triglyceride level in hepatocyte. In Indonesia there is not much research about this condition. Fatty liver is a major health problem in West countries, and is slowly increasing in Asian countries. For many individual with fatty liver, have no specific complaint or can have no symptoms at all. This aim of this study to analyzed the relationship between fatty liver images on abdominal CT scans with dyslipidemia. Methods: This study is an observational analytic study with a case – control type of research with the aim of knowing the relationship between CT scan images of fatty liver and dsylipidemia. The data in this study were all medical records who went to the Radiology Department for abdominal CT scan at the Haji Adam Malik General Hospital for a period of one year from January 1st, 2020 to December 31st 2020. Results: The subjects on the abdominal CT scan results with fatty liver and high triglyceride is 5 peoples out of 12 (41.7%). The test results obtained p value = 0.,688 (p>0,05), in other words there is no significant relationship between fatty liver and high triglyceride level. Conclusion: No significant relationship was found between the incidence of fatty liver and the incidence of dyslipidemia.
Correlation between Helicobacter Pylori Caga Antibody Serum and Gastric Premalignant Lesions in Helicobacter Pylori Patients Monica, Clarisa; Sungkar, Taufik; Ilhamd
Journal of Society Medicine Vol. 2 No. 10 (2023): October
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i10.91

Abstract

Introduction: Helicobacter pylori (H. pylori) is a spiral-shaped, anaerobic, and gram-negative pathogenic bacteria found in the gastric mucosa that causes chronic gastritis and gastric cancer. One of the most studied H. pylori virulence factors is the CagA protein in which positive anti-CagA antibodies increase the risk of malignancy in the stomach. This research was aimed to determine the correlations between Helicobacter pylori CagA antibody serum and gastric premalignant lesions in Helicobacter pylori patients. Method: This was a cross-sectional and analytic research. The sample of this study were patients diagnosed with Helicobacter pylori at Haji Adam Malik General Hospital in Medan who corresponded the inclusion criteria. The research was conducted from January to December 2022. The sampling technique used was consecutive sampling. Selected subjects underwent endoscopy and biopsy, as well as antibody detection of CagA, then the data analysis was carried out. Results: The number of samples that included in this study were 60 people. Based on demographic characteristics, the majority of patients were women, Batak ethnic, having a normal body mass index, not having a history of alcohol consumption, and non-smokers. The majority of people with Helicobacter pylori did not have CagA antibodies. There was a significant relationship (p=0.009) between  antibody of CagA and gastric premalignant lesions, as well as the prevalence ratio is 2.6. Conclusion: There is a correlation between antibody of CagA and gastric premalignant lesions in patients with Helicobacter pylori infection.
Differences in MPV (Mean Platelet Volume) / Lymphocytes Ratio In Chronic Hepatitis B with and without Cirrhosis Hepatic Elsha, Elsha Sinulingga; Siregar, Jelita; Sungkar, Taufik
Journal of Society Medicine Vol. 3 No. 6 (2024): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i6.151

Abstract

Introduction: The MPV/Lymphocyte Ratio is a simple inflammatory parameter that can be obtained from a complete blood count. Hepatitis patients with liver cirrhosis have a higher MPV causing thrombopoietin to decrease so that the platelet count decreases. The inflammatory response can cause a decrease in the number of lymphocytes and is closely related to a poor prognosis in patients with hepatitis B virus. This study aims to examine the differences in the MPV/Lymphocyte ratio in chronic hepatitis B patients with and without liver cirrhosis. Methods: The samples for this study was chronic hepatitis B patients with and without liver cirrhosis who met he inclusion criteria. The research was carried out by taking blood samples from 94 patients treated in the internal medicine treatment room and Gastroenterohepatology polyclinic at Adam Malik Hospital, Medan. Samples were examined for MPV, absolute lymphocytes, then the MPV/lymphocyte ratio was calculated. Results: The total number of subjects in this study was 94 and there were 62 men and 32 women. The results of the analysis showed that there was a significant difference between the cirrhotic and non-cirrhotic groups (p = 0.001). Conclusion: There was a significant difference in the ratio of MPV/lymphocytes in the group of hepatitis B subjects with cirrhosis and in the group of hepatitis B subjects without liver cirrhosis. (p = 0.001).
Proprotein convertase subtilisin/kexin type 9 (PCSK9) as a marker of coronary lesion severity in stable coronary artery disease (CAD) patients Andra, Cut A.; Rambe, Aldy S.; Hasan, Refli; Sembiring, Rosita; Firman, Doni; Eyanoer, Putri C.; Mukhtar, Zulfikri; Sungkar, Taufik; Rusda, Muhammad; Amin, Mustafa M.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.409

Abstract

Coronary artery disease (CAD) remains a significant global health concern with considerable high morbidity and mortality and its development is influenced by various genetic and environmental factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a vital regulator of low-density lipoprotein receptor (LDLR) metabolism, directly impacting serum cholesterol levels. However, its role in development of CAD is not fully understood. The aim of this study was to assess the association between the level of PCSK9 and coronary lesion severity in patients with CAD. A case-control study using consecutive sampling was conducted among CAD patients at H. Adam Malik General Hospital and Murni Teguh Memorial Hospital, Medan, Indonesia. A total of 200 CAD patients were divided into two groups based on the SYNTAX score: control (score ≤22, n=100) and case (score >22, n=100). Plasma PCSK9 levels were measured from venous blood using quantitative sandwich enzyme immunoassay. The Chi-squared test was used to analyze the data. Our data suggested that PCSK9 level was associated with coronary lesion severity (p<0.001) of which high PCSK9 level was associated with severe coronary lesion. We also found that hypertension (p<0.001), smoking (p=0.072), diabetes (p<0.001), dyslipidemia (p<0.001), obesity (p=0.023), and family history (p=0.001) were associated with lesion severity. Using the receiver operating characteristic (ROC) curve analysis, the cut-off 70.35 ng/mL of PCSK9 had sensitivity 75% and specificity 78% to predict severe coronary lesion. This study highlights that PCSK9 level has moderate sensitivity and specificity to predict the coronary lesion severity among CAD patients.
Relationship Between Staging and Carcinoembryonic Antigen Serum Levels In Colorectal Cancer Patients' Agusrly, Chandra; Sungkar, Taufik; Siregar, Gontar Alamsyah
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 3 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (642.483 KB) | DOI: 10.32734/jetromi.v2i3.3959

Abstract

The staging can be used as one of the prognostic factors providing a clinical picture of the patient in the future in colorectal cancer patient. In addition, carcinoembryonic antigen (CEA) as tumor markers can determine the commonly used diagnosis and prognosis of colorectal cancer. Objective: The aims study was to investigate the relationship of the staging and carcinoembryonic antigen serum levels in colorectal cancer patients. Methods. This was an analytical study with a cross-sectional design. The sample used was colorectal cancer patients at H. Adam Malik General Hospital, Medan from January 2016 to December 2018. As many as 52 subject study who met the inclusion and exclusion criteria. The Kruskal-Wallis test was used to determine relationship between staging and CEA serum levels. Results: The median value of carcinoembryonic antigen levels in Stage I, II, III, and IV group was (2.74 ng/ml vs 6.16 ng/ml vs 2.52 ng/ml, vs 26.87 ng/ml; p=0.003) respectively. Conclusion: There was relationship between staging and carcinoembryonic antigen serum levels in colorectal cancer patient
Association between Body Mass Index (BMI) and the Incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) Villarsi, Devinda; Sungkar, Taufik
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 1 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i1.14771

Abstract

Background: The prevalence of obesity among the population has risen dramatically due to a sedentary lifestyle. Obesity is a risk factor for the incidence of non-alcoholic fatty liver disease (NAFLD) and the prevalence of NAFLD rises to 90% in obese. NAFLD is a clinically silent disease that has become one of the most common causes of liver disease worldwide also due to multiple extrahepatic complications or comorbidities. This study aims to find the association between the Body mass index (BMI) and the incidence of NAFLD. Method: This analytic study with a cross-sectional design was conducted on the 3rd of July 2022 in Boho Village, Samosir District of North Sumatra. The participants were based on a simple random sampling that meets the criteria of inclusion. BMI was calculated as weight in kilograms divided by the square of height in meters (kg/m2), meanwhile, we performed an abdominal ultrasound to diagnose NAFLD. Statistical analyses were performed using SPSS and using Chi-Square test to see the association between BMI and the incidence of NAFLD. Result: Among of 48 participants, most of them were fatty liver grade 1 (31.25%), and Overweight/Obese (62.5%). The incidence of NAFLD is more prevalent in obese than non-obese participants (p = 0.0001). Conclusion: The most of participants were fatty liver grade 1 (31.25%), and Overweight/Obese (62.5%). There was a significant association between BMI and the incidence of NAFLD
Co-Authors Agusrly, Chandra Akbar, Fariz Nugraha Amin, Mustafa M. Andra, Cut A. Dairi, Laura Daulay, Elvita Rahmi Doni Firman Elsha, Elsha Sinulingga Eyanoer, Putri C. Gontar Alamsyah Siregar Hasan, Refli Ilhamd Imelda Rey Loesnihari, Ricke Lukman Hakim Zain Monica, Clarisa Mukhtar, Zulfikri Rambe, Aldy S. Rusda, Muhammad Sasmita, Afrianda Wira Sembiring, Rosita Siregar, Jelita Siregar, Wira Prihatin Villarsi, Devinda Zulkhairi Zulkhairi, Zulkhairi