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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana
Mahayasa, I Made
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Health Professions Medicine & Pharmacology

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Profil Pasien Kanker Kolorektal di RSUP Sanglah Tahun 2019 Krismayanti, Ni Kadek Putri Lia; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Mulyawan, I Made
E-Jurnal Medika Udayana Vol 12 No 9 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i09.P04

Abstract

Colorectal cancer is a malignancy which that usually arises from the gland or epithelial cells of the large intestine. Based on data from GLOBOCAN 2018, colorectal cancer is the third most deadly and fourth most commonly cancer in the world. The aim of this study is to determine the profile of colorectal cancer patients at Sanglah General Hospital in 2019. This research is a descriptive study with the cross sectional method. Samples were selected from the population based on inclusion and exclusion criteria. The subjects of this study were 38 colorectal cancer patients at Sanglah General Hospital in 2019. Data were collected from medical records and it is analyzed using SPSS version 26. The result of this study showed that the profile of colorectal cancer patients at Sanglah General Hospital in 2019 greatly varied, which most occurred in the <60 years age group and dominated by male. Based on the occupation, most categories were miscellaneous (IRT and Retired) with a very normal BMI. All patients had no previous family history of colorectal cancer. The majority of the samples had a history of fiber consumption more than twice a day. Most of them did not consume alcohol with physical activity. The most common tumor’s location was in the rectum with the most histopathological findings of adenocarcinoma. Most tumor was in stage III and combination was the most common method for the management. This finding is beneficial because it provides insight into the description of colorectal cancer patients at Sanglah General Hospital in 2019. Further analytical research is indispensable to find the correlation between various variables. Keywords : Profile, Colorectal Cancer, Sanglah General Hospital
Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats Fernandi, Ryan; Sudartana, I Ketut; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Yasa, Ketut Putu; Wibawa, I Gusti Agung Bagus Krisna
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.36698

Abstract

Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl ) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage.
Co-Authors Fernandi, Ryan Ketut Putu Yasa Krismayanti, Ni Kadek Putri Lia Mulyawan, I Made Sudartana, I Ketut Sueta, Made Agus Dwianthara Wibawa, I Gusti Agung Bagus Krisna