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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana Cermin Dunia Kedokteran
Sueta, Made Agus Dwianthara
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Health Professions Medicine & Pharmacology Public Health

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Konsep Patofisiologi Motilitas Gastrointestinal Dewi Prawira, Mira; Sueta, Made Agus Dwianthara
Cermin Dunia Kedokteran Vol 47, No 1 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i1.335

Abstract

Sistem gastrointestinal (GI) mempunyai fungsi sebagai tempat persediaan air, elektrolit, dan kimus. Fungsi sistem GI yaitu motilitas usus antara lain mixing, propulsion, dan separation. Motilitas usus secara fisiologis mendapat sinyal dari beberapa agen regulator eksitatorik dan inhibitorik. Gangguan motilitas GI dapat dibagi menjadi obstruksi mekanik (dinamik) dan ileus paralitik (adinamik), selain itu juga ada pengaruh medikamentosa terhadap motilitas GI. GI motility have various functions, such as mixing, propulsion and separation. GI motility is regulated by signals from excitatory agents and inhibitory agents. GI motility disorders can be divided into mechanical (dynamic) obstruction and paralytic ileus (adynamic); some pharmacological agents also can affect GI motility.
Profil Pasien Kanker Kolorektal di RSUP Sanglah Tahun 2019 Krismayanti, Ni Kadek Putri Lia; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Mulyawan, I Made
E-Jurnal Medika Udayana Vol 12 No 9 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i09.P04

Abstract

Colorectal cancer is a malignancy which that usually arises from the gland or epithelial cells of the large intestine. Based on data from GLOBOCAN 2018, colorectal cancer is the third most deadly and fourth most commonly cancer in the world. The aim of this study is to determine the profile of colorectal cancer patients at Sanglah General Hospital in 2019. This research is a descriptive study with the cross sectional method. Samples were selected from the population based on inclusion and exclusion criteria. The subjects of this study were 38 colorectal cancer patients at Sanglah General Hospital in 2019. Data were collected from medical records and it is analyzed using SPSS version 26. The result of this study showed that the profile of colorectal cancer patients at Sanglah General Hospital in 2019 greatly varied, which most occurred in the <60 years age group and dominated by male. Based on the occupation, most categories were miscellaneous (IRT and Retired) with a very normal BMI. All patients had no previous family history of colorectal cancer. The majority of the samples had a history of fiber consumption more than twice a day. Most of them did not consume alcohol with physical activity. The most common tumor’s location was in the rectum with the most histopathological findings of adenocarcinoma. Most tumor was in stage III and combination was the most common method for the management. This finding is beneficial because it provides insight into the description of colorectal cancer patients at Sanglah General Hospital in 2019. Further analytical research is indispensable to find the correlation between various variables. Keywords : Profile, Colorectal Cancer, Sanglah General Hospital
FAKTOR TERJADINYA HEMORRHOID DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR BALI TAHUN 2020 Surya, Maria Angeline Ivana; Sueta, Made Agus Dwianthara; Mahayasa, Made; mulyawan, Made
E-Jurnal Medika Udayana Vol 11 No 12 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i12.P17

Abstract

Hemoroid adalah dilatasi varikosus vena atau pelebaran pembuluh darah vena dari pleksus hemorrhoidal inferior dan superior, dikarenakan peningkatan tekanan pembuluh vena. Kondisi ini menyerang kurang lebih 30 dari 52% orang dewasa di dunia. Penyebab dari hemorrhoid ini sendiri masih idiopathic atau belum banyak diketahui, tapi banyak faktor yang diduga menjadi risiko terjadinya hemoroid seperti umur, jenis kelamin, riwayat keluarga, kurangnya konsumsi serat, konstipasi, dan overweight. Sedangkan untuk penelitian mengenai faktor risiko kejadian hemorrhoid di Bali masih sangat terbatas, terutama pada RSUP Sanglah Denpasar, sehingga belum ditemukan faktor risiko dominan tentang terjadinya hemorrhoid atau wasir tersebut. Sehingga, penelitian ini bertujuan untuk mengetahui faktor terjadinya hemoroid pada RSUP Sanglah Denpasar tahun 2020. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Teknik pengumpulan data dilakukan dengan consecutive sampling yaitu cara pengambilan sampel dimana semua subjek datang pada jangka waktu tertentu dan memenuhi kriteria pemilihan dimasukkan dalam penelitian sampai besar sampel yang diperlukan terpenuhi. Terdapat 50 data penelitian yang terkumpul dengan 29 data dari pasien hemoroid dan 21 data dari pasien bukan hemoroid yang dirawat di poli bedah digestif RSUP sanglah Denpasar pada tahun 2020. Hasil dari penelitian ini adalah ditemukan adanya hubungan yang signifikan antara kurangnya konsumsi serat (PR= 1,75; 95% CI 3,61(1,11-11,76); P=0,03), konstipasi (PR= 1,80; 95% CI 4,53 (1,30-15,77); P= 0,014), dan overweight (PR= 1,7; 95% CI 3,94 (1,14-13,65); P=0,027) dengan kejadian hemoroid dan tidak terdapat hubungan antara usia (PR= 0,89; 95% CI 0,76 (0,24 – 2,38); P= 0.634), jenis kelamin (PR= 1,01; 95% CI 1,03 (0,33 – 3,16); P=0,963), dan riwayat keluarga (PR= 1,44; 95% CI 3,2 ( 0,33-30,94 ); P= 0,293) dengan kejadian hemoroid di RSUP Sanglah Denpasar tahun 2020. Selanjutnya Berdasarkan analisa untuk melihat kekuatan hubungan masing-masing faktor resiko dengan kejadian Hemoroid, dengan menggunakan analisa multivariat regresi logistik, didapatkan penderita dengan konstipasi memiliki hubungan yang paling kuat dengan kejadian Hemoroid (p=0,028, 95% CI = 1,19 – 22,92).
Peritoneal lavage with sterile water reduces IL-1 levels and postoperative adhesions following laparotomy in rats Fernandi, Ryan; Sudartana, I Ketut; Sueta, Made Agus Dwianthara; Mahayasa, I Made; Yasa, Ketut Putu; Wibawa, I Gusti Agung Bagus Krisna
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.36698

Abstract

Peritoneal lavage with normal saline is common in abdominal surgeries, yet recent studies indicate that it increases intraperitoneal adhesion risks. This study compares the effects of peritoneal lavage with normal versus sterile water on interleukin-1 (IL-1) levels and intraperitoneal adhesion following laparotomy in rats. In this post-test control group study, 20 adult Wistar rats were subjected to laparotomy before being randomly divided into two groups to receive either intraperitoneal lavage with normal saline (0.9% NaCl ) or sterile water. After 7 days, IL-1 level and degree of adhesion were evaluated. The saline group had higher adhesion levels (4 rats with grade 4, 5 with grade 3, 1 with grade 2) than the sterile water group, which had lower levels (2 rats with grade 3, 5 with grade 2, 3 with grade 1). There was a significant difference in IL-1 levels between the sterile water group (37,111.6 ± 6,535.61 pg/ml) and the normal saline group (57,456.3 ± 10,583.41 pg/ml). There was a significant correlation between IL-1 levels and adhesion grade (p=0.008). Intraperitoneal lavage with sterile water results in significantly lower adhesion grade and IL-1 levels than normal saline, suggesting its potential for reducing postoperative adhesions. Further studies are needed to elucidate the mechanism of reduced adhesion and inflammation associated with sterile water lavage.
Co-Authors Dewi Prawira, Mira Fernandi, Ryan Ketut Putu Yasa Krismayanti, Ni Kadek Putri Lia Mahayasa, I Made Mahayasa, Made Mulyawan, I Made mulyawan, Made Sudartana, I Ketut Surya, Maria Angeline Ivana Wibawa, I Gusti Agung Bagus Krisna