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All Journal Sari Pediatri Paediatrica Indonesiana Journal of Community Empowerment for Health
Nurputra, Dian Kesumapramudya
Department Of Child Health, Faculty Of Medicine, Public Health, And Nursing Universitas Gadjah Mada / RSUP Dr Sardjito Indonesia Bhayangkara Police Owned General Hospital, Kalasan-DI Yogyakarta
Education Health Professions Medicine & Pharmacology Nursing Public Health

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Luaran Terapi Gancyclovir dan atau Valgancyclovir pada Pasien Infeksi Cytomegalovirus di Instalasi Kesehatan Anak RSUP Dr Sardjito Agung Triono; Elisabeth Siti Herini; Braghmandita Widya Indraswari; Dian Kesumapramudya Nurputra; Sari Wardhani
Sari Pediatri Vol 22, No 1 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp22.1.2020.1-6

Abstract

Latar belakang. Infeksi Cytomegalovirus (CMV) merupakan penyebab tersering infeksi kongenital anak di negara berkembang. Infeksi ini dapat menyebabkan tuli sensorineural (SNHL) dan gangguan perkembangan. Di RSUP dr Sardjito, pasien dengan infeksi CMV aktif bergejala akan menjalani terapi 6 minggu Ganciclovir atau 2 minggu terapi Ganciclovir dilanjutkan 4 minggu terapi Valganciclovir. Namun, luaran terapi tersebut belum diteliti lebih lanjut.Tujuan. Melihat luaran terapi ganciclovir dan atau valganciclovir pada pasien infeksi Cytomegalovirus di Instalasi Kesehatan Anak RSUP Dr Sardjito.Metode. Penelitian ini menggunakan metode kohort retrospektif dari data rekam medis pasien dengan diagnosis infeksi CMV aktif di Instalasi Kesehatan Anak RSUP dr Sardjito periode Januari 2014 sampai dengan April 2018. Variabel luaran (BERA dan Denver II) dibandingkan antara pre dan post terapi ganciclovir. Analisis statistik data dasar menggunakan analsisi deskriptif. Untuk variable luaran menggunakan T test.Hasil. Didapatkan hasil yang signifikan untuk perbaikan fungsi pendengaran pada telinga kanan (p<0,001) dan kiri (p<0,03) dibandingkan dengan yang mengalami perburukan. Sementara untuk perbandingan gangguan perkembangan sebelum dan sesudah terapi ganciclovir tidak berbeda bermakna (p>0,05).Kesimpulan. Pemberian terapi ganciclovir dan valganciclovir dapat memperbaiki fungsi pendengaran (tes BERA), tetapi perbaikan tidak didapatkan pada aspek neurodevelopmental (tes Denver II) dari pasien dengan infeksi CMV.
Potentially predictive factors for hearing function improvement in pediatric cytomegalovirus infection therapy Agung Triono; Elisabeth Siti Herini; Braghmandita Widya; Dian Kesumapramudya Nurputra
Paediatrica Indonesiana Vol 61 No 5 (2021): September 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.5.2021.235-9

Abstract

Background Symptomatic congenital cytomegalovirus (CMV) infection has an impact mainly on neurological sequelae, including sensorineural deafness. Because of the long-term impact, early treatment of CMV infection is mandatory. However, predictive factors for hearing function improvement in CMV infection therapy remain unexamined. Objective To evaluate potential predictive factors for hearing improvement in pediatric CMV infection therapy. Methods All medical record data of patients aged 0-6 years with CMV infection who completed a 6-week course of ganciclovir therapy or a combination of a 4-week course of ganciclovir and a 2-week course valganciclovir from January 2013 to December 2017 were collected. Age at onset of therapy, gender, gestational age, nutritional status, multi-organ involvement, and neurological symptoms were studied as potential predictive factors of hearing improvement in CMV therapy. The effectiveness of CMV infection therapy on improving hearing function was measured with the brainstem evoked response audiometry (BERA) test. Results BERA tests proportion in the right, left, and best ear showed significant improvement after therapy. All variables analyzed were not statistically significant as predictive factors for hearing improvement in CMV infection therapy. Conclusion Ganciclovir/valganciclovir therapy in CMV infection patients accounted for the improvement of hearing impairment. However, none of the assessed factors were considered predictive for improving hearing function in CMV infection therapy.
School reopening: Evidence-based recommendations during COVID-19 pandemic in Indonesia Raden Yuli Kristiyanto; Lily Chandra; Hermawan Hanjaya; Mohamad Saifuddin Hakim; Dian Kesumapramudya Nurputra
Journal of Community Empowerment for Health Vol 4, No 1 (2021): Special Issue of COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.57524

Abstract

Since the first Coronavirus Disease 2019 (COVID-19) case was reported, it has run amok and caused global changes. It has affected human lives in almost every aspect, including education. In response to COVID-19, governments and policy-makers decided to shift the educational activities into online learning and institute school closure. As of March 2020, many countries worldwide have implemented school closure, including Indonesia. Large scale social distancing and stay-at-home policies have begun to negatively impact society’s physical and mental health. As people start to adapt to the first wave of the COVID-19 pandemic, policy-makers and the government need to consider how to reopen the schools and its system to keep students and staff safe. School reopening is an important step toward loosening the lockdown. Schools play a crucial role in preserving children's well-being. The objective of this review was to give a recommendation to facilitate school reopening. Research articles were gathered and assessed based on the themes of the articles. Forty articles were found reflecting SARS-CoV-2 and school reopening. Findings were adapted and modified according to Indonesian situations during the SARS-CoV-2 pandemic. Indonesia is currently preparing the first steps toward school reopening. For schools to be reopened, there are several health measurements that need to be considered. A good collaboration between various authorities and stakeholders is essential in school reopening so that children’s safety and disease mitigation strategies remain stable. This review presents insights and recommendations for every element involved in school safety including the government, schools, teachers, parents and students including what each needs to do to prepare in advance for the up-coming decision to reopen schools. 
Co-Authors Agung Triono Braghmandita Widya Braghmandita Widya Indraswari Elisabeth Siti Herini Elisabeth Siti Herini Hermawan Hanjaya Lily Chandra Mohamad Saifuddin Hakim Raden Yuli Kristiyanto Sari Wardhani