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All Journal Dentino: Jurnal Kedokteran Gigi Dentin
Wasiaturrahmah, Yusrinie
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Dentistry

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Journal : Dentino: Jurnal Kedokteran Gigi

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EFFECT OF GALAM LEAF EXTRACT AND TRI-CALCIUM SILICATE CEMENT ON NEUTROPHIL CELLS IN WISTAR RAT PULP Putra, Fedriko Gamaliel; Diana, Sherli; Dewi, Nurdiana; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20409

Abstract

Background: Pulp capping is a method of sealing the pulp chamber in teeth with cavities that extend to the pulp. Direct pulp capping involves applying a material directly onto the exposed pulp tissue. Tri-calcium silicate cement (Ca3SiO5) is commonly used due to its nanoparticle mineral composition, but it can cause continued inflammation. Galam leaf (Melaleuca cajuputi) is known for its anti-inflammatory properties, owing to secondary metabolites like alkaloids, flavonoids, polyphenols, and saponins, potentially compensating for the drawbacks of tri-calcium silicate cement. Purpose: To determine the effect of combining Galam leaf extract (Melaleuca cajuputi subsp. Cumingiana (Turz) Barlow) with tri-calcium silicate cement as a direct pulp capping material on neutrophil cell count in the pulp of Wistar rats (Rattus norvegicus). Methods: This pure experimental study used a posttest-only control design. Thirty-six Wistar rats were divided into nine groups: one received a combination of 100% Galam leaf extract and tri-calcium silicate cement; one positive control group received tri-calcium silicate cement alone; and one negative control group received direct placement with glass ionomer cement (GIC). The neutrophil cell count was assessed on days 1, 2, and 3. Results: Two-way ANOVA results indicated a significant effect based on treatment and time (p < 0.05). Further analysis with the Post Hoc Bonferroni test (p < 0.05) revealed differences in neutrophil cell counts across nearly all groups on days 1, 2, and 3. Conclusion: The combination of 100% Galam leaf extract and tri-calcium silicate cement significantly reduced neutrophil cell counts compared to both positive and negative control groups on days 1, 2, and 3, indicating anti-inflammatory effect.
QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE Namira Aghnina, A.M. Della; Puspitasari, Dewi; Wasiaturrahmah, Yusrinie
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18853

Abstract

Background: Mauli banana stem extract and basil leaves extract are ingredients that has been involved in in vitro and in vivo researches for their pharmacognosy and therapeutic applications. Preliminary phytochemical test of both individual extract revealed the presence of triterpenoid, tannin, phenolic, saponin, steroid, alkaloid, and flavonoid compound. A combination of mauli banana stem and basil leaves extract is believed to work synergistically and may have a more beneficial effect than in single herbal extract. Purpose: To analyze the results of quantitative phytochemical of mauli banana stem and basil leaves extract mixture. Method: Non-experimental research with quantitative laboratory examination to determine sample content. Results: The result showed that mauli banana stem and basil leaves extract mixture contain triterpenoid (30%), saponin (24,75%), flavonoid (15%), alkaloid (22%), phenolic (8%), steroid (4,62%), and tannin (0,03%). Conclusion: Mauli banana stem and basil leaves extract mixture correlated with an increase in majority of the bioactive compound compared to the single extract and would serve as a promising source for phytomedicine. The bioactive compound with the highest content was triterpenoid with 30%, while the lowest was tannin with 0,03%. Keywords: Basil leave extract, Mauli banana stem extract, Quantitative phytochemical test
Co-Authors Amy Nindia Carabelly Aspriyanto, Didit Azzam, Kholish Atikah Dewi Nurdiana Dewi Puspitasari Diana Wibowo Maulana, Noval Ihza Namira Aghnina, A.M. Della Putra, Fedriko Gamaliel Rosihan Adhani, Rosihan Sherli Diana Sitepu, Alexander Tri Putri, Deby Kania