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Fatmawati Madya
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Education Health Professions Library & Information Science Nursing Public Health

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Kadar Endotelin -1 Pada Ibu Hamil Trimester Iii Dengan Hipertensi Gestasional Tumani, Yuni Kristiani; Irfan Idris; Fatmawati Madya
Jurnal Bidan Cendrawasih Palu Vol 2 No 1 (2020): Maret
Publisher : Akademi Kebidanan Palu Sulawesi Tengah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47303/jbcp.v2i1.20

Abstract

Hipertensi gestasionalmerupakan penyebab angka kematian ibu (AKI) terbesar kedua di Indonesia, dimana terjadi peningkatan fungsi endotel, yaitu endotelin-1 (ET-1). Tujuan penelitian ini adalah untuk mengetahui kadar ET-1 pada kehamilan normal dan hipertensi gestasional.Sebanyak 40 ibu hamil trimester III yang diambildengan teknik pengambilan sampel Purposive sampel terbagi atas 20 ibu hamil dengan kehamilan normal dan 20 ibu hamil dengan hipertensi gestasional di ambil sampel darahnya sebanyak 3 mL, yang kemudian di bawah ke Laboratorium RSUP Universitas Hasanuddin untuk pemeriksaan kadar ET-1 menggunakan Human Endothelin-1 ELISA Kit. Analisa data menggunakan uji Mann Whitney U, hasil menunjukkan tidak ada perbedaan bermakna antara kadar ET-1 pada ibu hamil trimester III dengan kehamilan normal dan hipertensi gestasional, p=0,372 (p>0,05), dimana kadar ET-1 lebih tinggi pada kehamilan normal.
Kadar Nitrat Okside Pada Ibu Hamil Trimester III Dengan Hipertensi Gestasional Juwita; Irfan Idris; Fatmawati Madya
Jurnal Bidan Cendrawasih Palu Vol 2 No 2 (2020): SEPTEMBER
Publisher : Akademi Kebidanan Palu Sulawesi Tengah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47303/jbcp.v2i2.28

Abstract

Nitric Oxcide is an essential amino acid L-arginine in vascular endothelial cells and mediates relaxation of smooth muscle which causes vaso contraception of capillary vessels, that causes increasing blood pressure and becoming hypertension. This study aims to determine whether the value of Nitric Oxcide levels in hypertension pregnant women is lower or higher than pregnant women without hypertension. The study was conducted at RSIA St. Fatimah Makassar, Jumpandang Baru Health Center and Antang Perumnas Health Center, with the research method using a purposive sampling technique in accordance with the inclusion criteria of trimigravida pregnant women, third trimester pregnant women, diagnosed with gestational hypertension based on the results of the examination and medical record, willing to be a respondent and sign an informed consent. The results showed that the Nitric Oxside level in gestasional hypertension pregnant women (13.31 ng/ml) was higher than the Nitric Oxcide level of pregnant women without gestational hypertension (11.88 ng/ml) and then Mann Whitney test was performed p = 0.787 ( p ≥ 0.05).
Co-Authors Irfan Idris Juwita Yuni Kristiani Tumani