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All Journal PHARMACON Kesmas: Jurnal Kesehatan Masyarakat Nasional Jurnal Kesehatan Tambusai Medical Scope Journal (MSJ)
DEBY AFRIANI MPILA
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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IDENTIFIKASI INTERAKSI OBAT POTENSIAL PADA PASIEN STROKE RAWAT INAP DI RSUP PROF. DR. R. D. KANDOU MANADO Solang, Natasia G; Wiyono, Weny; Mpila, Deby Afriani
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32749

Abstract

ABSTRACTMost stroke patients receive polypharmacy, because most stroke patients have complications. Stroke therapy is important because if an interaction occurs, it can cause an increased risk of hospitalized patients and higher health care costs. This study is a descriptive study which aims to determine the prevalence of potential drug interactions that occur in inpatients of stroke hospitalization at Prof. Dr. R. D. Kandou Manado with retrospective data collection in October-December 2017. Samples were obtained as many as 40 patients. The results showed potential drug interactions in 20 patients (50%), with 57 potential interactions. Based on the mechanism, 30 events (52.63%) were pharmacokinetic, 15 events (26.31%) included in the pharmacokinetic and pharmacodynamic combination and 12 events (21.05%) were pharmacodynamic. The potential severity of the drug, at the moderate level was found to be 27 potential (47.36%), at the minor level 16 potential (28.07%) and at the major level with 14 potential (24.56%). Keywords: Drug Interaction, Stroke ABSTRAKKebanyakan pasien stroke menerima obat polifarmasi karena sebagian besar pasien stroke mengalami komplikasi. Terapi penyakit stroke sangat penting karena jika terjadi interaksi dapat menyebabkan peningkatan risiko pasien dirawat rawat inap dan biaya perawatan kesehatan akan lebih tinggi. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk mengetahui prevalensi interaksi obat potensial yang terjadi pada pasien stroke rawat inap di RSUP Prof. Dr. R. D. Kandou Manado dengan pengambilan data secara retrospektif pada bulan oktober-desember 2017. Sampel diperoleh sebanyak 40 pasien. Hasil penelitian menunjukan adanya interaksi obat potensial pada 20 pasien (50%), dengan jumlah potensial interaksi sebanyak 57 kejadian. Berdasarkan mekanismenya, 30 kejadian (52,63%) merupakan farmakokinetik, 15 kejadian (26,31%) termasuk dalam kombinasi farmakokinetik dan farmakodinamik dan 12 kejadian (21,05%) merupakan farmakodinamik. Tingkat keparahan potensial interaksi obat, pada tingkat moderate didapati 27 potensi (47,36%), pada tingkat minor 16 potensi (28,07%) dan pada tingkat major dengan 14 potensi (24,56%). Kata Kunci: Interaksi Obat, Stroke
EVALUASI PENGGUNAAN OBAT PADA PASIEN PPOK (PENYAKIT PARU OBSTRUKTIF KRONIS) DI INSTALASI RAWAT JALAN RSUP PROF. DR. R.D. KANDOU MANADO Hathasary, Rochmat Hidayat; Wiyono, Weny; Mpila, Deby Afriani
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32748

Abstract

ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by limited airflow in the airways that is not completely reversible and is progressive. The accuracy of drug use in this study is that patients receive treatment which is then evaluated for its accuracy based on the right category of indication, right drug, right patient, and right dose. This study aims to identify the characteristics and presentation of the accuracy of drug use in COPD patients. This study is a descriptive study with retrospective data collection from 30 medical records of  COPD patients for the period July - September 2020. The results of the study based on the characteristics of COPD patients showed that the number of male patients was greater than that of women, namely 23 patients (76.67%) and The highest number of patients was in the 56-65 years age group of 13 patients (43.33%). Diseases of the digestive system were the most common comorbidities found in 2 patients (6.67%) and 3-4 drugs were prescribed more, namely in 16 patients (53.34%). The percentage of accuracy of drug use consisted of 93.33% right indication, 53.33% right drug, 100% correct patient, and 96.67% correct dose. Keywords: drug evaluation , COPD, outpatient  ABSTRAKPenyakit Paru Obstruksi Kronik (PPOK) adalah penyakit paru kronik yang ditandai dengan keterbatasan aliran udara di dalam saluran napas yang tidak sepenuhnya reversible dan bersifat progresif. Ketepatan penggunaan obat dalam penelitian ini adalah pasien menerima pengobatan yang kemudian di evaluasi ketepatannya berdasarkan kategori tepat indikasi, tepat obat, tepat pasien, dan tepat dosis.Penelitian ini bertujuan untuk mengidentifikasi karakteristik dan presentasi ketepatan penggunaan obat pada pasien PPOK. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dari 30 catatan rekam medik pasien PPOK periode Juli - September 2020. Hasil penelitian berdasarkan karakteristik pasien PPOK menunjukkan jumlah pasien laki-laki lebih banyak dibanding perempuan yaitu sebesar 23 pasien (76,67%) dan jumlah pasien terbanyak pada kelompok usia 56-65 tahun sebesar 13 pasien (43,33%). Penyakit pada sistem pencernaan merupakan penyakit penyerta terbanyak yang ditemukan pada 2 pasien (6,67%) dan 3-4 obat diresepkan lebih banyak yaitu pada 16 pasien (53,34%). Persentase ketepatan penggunaan obat terdiri dari tepat indikasi 93,33%, tepat obat 53,33%, tepat pasien 100%, dan tepat dosis 96,67%. Kata kunci: Evaluasi Obat, PPOK, rawat jalan
EVALUASI PENGGUNAAN OBAT PADA PASIEN ASMA DI INSTALASI RAWAT INAP RSUP PROF. DR. R. D. KANDOU MANADO Alotia, Gerry S.; Wiyono, Weny I.; Mpila, Deby A.
PHARMACON Vol 9, No 4 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.31372

Abstract

ABSTRACTAsthma is a disease in the top five causes of death in the world, which varies between 5-10%. Drug use accuracy in this study was that patients who received treatment were evaluated for accuracy based on the category of indication, drug, patient and the correct dose. This study aims to identify the characteristics and presentation of the accuracy of drug use in asthma patients. This study is a descriptive study with retrospective data collection from 59 medical records of asthma patients for the period January - December 2017. The results of the study based on the characteristics of asthma patients show the number of female patients more than men, namely 33 patients (55.93%) and the highest number of patients age is in the 56 - 65 years for 10 patients (16.95%). Endocrine diseas, nutritional and metabolic disorders were the most common comorbidities was found in 13 patients (17.33%) and 3-4 drugs were prescribed more, namely 28 patients (47.46%). The accuracy percentage of drug use consisted of 81.36% right indication, 74.58% right drug, 94.92% right patient, and 86.44% correct dose. Keywords: Inpatient Asthma, Drug evaluation  ABSTRAKPenyakit asma merupakan penyakit lima besar penyebab kematian di dunia yang bervariasi antara 5 - 10%. Ketepatan penggunaan obat dalam penelitian ini adalah pasien menerima pengobatan yang kemudian di evaluasi ketepatannya berdasarkan kategori tepat indikasi, tepat obat, tepat pasien, dan tepat dosis. Penelitian ini bertujuan untuk mengidentifikasi karakteristik dan presentasi ketepatan penggunaan obat pada pasien asma. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dari 59 catatan rekam medik pasien asma periode Januari - Desember 2017. Hasil penelitian berdasarkan karakteristik pasien asma menunjukkan jumlah pasien perempuan lebih banyak dibanding laki-laki yaitu sebesar 33 pasien (55,93%) dan jumlah pasien terbanyak pada kelompok usia 56 - 65 tahun sebesar 10 pasien (16,95%). Penyakit endoktrin, nutrisi dan gangguan metabolik merupakan penyakit penyerta terbanyak yang ditemukan pada 13 pasien (17,33%) dan 3 - 4 obat diresepkan lebih banyak yaitu pada 28 pasien (47,46%). Persentase ketepatan penggunaan obat terdiri dari tepat indikasi 81,36%, tepat obat 74,58%, tepat pasien 94,92%, dan tepat dosis 86,44%. Kata Kunci: Asma rawat inap, Evaluasi obat
PENGETAHUAN, PERSEPSI DAN HARAPAN MASYARAKAT TERHADAP PROFESI APOTEKER SELAMA PANDEMI COVID-19 DI BEBERAPA APOTEK KECAMATAN SARIO Subadio, Nathanael Yngwie Christian; Wiyono, Weny; Mpila, Deby A.
PHARMACON Vol 11, No 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39140

Abstract

ABSTRACTPharmacists are Pharmacists who have graduated as Pharmacists and have taken the oath of office of Pharmacists. Pharmacists are required to provide pharmaceutical care at a Pharmacy under the Regulation of the Minister of Health number 73 of 2016. This study aims to know the knowledge, perception and expectations of the community towards the Pharmacist during the Covid-19 pandemic in several Pharmacies in the Sario District. This study is a qualitative descriptive study with in-depth interviews with 28 respondents who met the inclusion criteria. The results obtained are that the public knows the existence of Pharmacists in Pharmacies and the pharmaceutical care only prescription services and drug information services, in the form of information on the use and how to take drugs. Meanwhile, the public can only provide descriptions related to counseling services, home pharmacy care, therapeutic drug monitoring and monitoring of drug side effects. The public hopes that the Pharmacist at the Pharmacy can provide telemedicine services during the Covid-19 pandemic. The community also expects Pharmacists to introduce their profession to the community, increase the presence of Pharmacists in Pharmacies and provide comprehensive pharmaceutical care.Keywords: Public, pharmaceutical care, knowledge, perception, expectationABSTRAKApoteker merupakan sarjana farmasi yang telah lulus Apoteker dan mengucapkan sumpah jabatan Apoteker. Apoteker dituntut untuk melakukan pelayanan kefarmasian di Apotek sesuai Peraturan Menteri Kesehatan nomor 73 tahun 2016. Penelitian ini bertujuan untuk mengetahui pengetahuan, persepsi dan harapan masyarakat terhadap profesi Apoteker selama pandemi Covid-19 di beberapa Apotek Kecamatan Sario. Penelitian ini merupakan penelitian deskriptif kualitatif dengan wawancara mendalam terhadap 28 responden yang memenuhi kriteria inklusi. Hasil penelitian diperoleh yaitu masyarakat mengetahui keberadaan Apoteker di Apotek dan pelayanan kefarmasian yang dilakukan hanya pada pelayanan resep dan pelayanan informasi obat, berupa informasi kegunaan dan cara penggunaan obat. Sedangkan masyarakat hanya memberikan gambaran terkait pelayanan konseling, pelayanan kefarmasian di rumah, pemantauan terapi obat dan monitoring efek samping obat. Masyarakat berharap profesi Apoteker di Apotek dapat memberikan pelayanan telemedicine selama pandemi Covid-19. Masyarakat juga mengharapkan Apoteker dapat memperkenalkan profesinya ke masyarakat luas, meningkatkan kehadiran Apoteker di Apotek dan memberikan pelayanan kefarmasian secara menyeluruh.Kata kunci: Masyarakat, pelayanan kefarmasian, pengetahuan, persepsi, harapan
Quality of Life of Hypertensive Patients Undergoing Chronic Disease Management Program during the COVID-19 Pandemic Widya Astuty Lolo; Gayatri Citraningtyas; Deby Afriani Mpila; Heri Wijaya; Sandeep Poddar
Jurnal Kesehatan Masyarakat Nasional Vol 17, No 4 (2022): Volume 17, Issue 4, November 2022
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21109/kesmas.v17i4.6224

Abstract

The COVID-19 pandemic has restricted some common activities for hypertensive patients undergoing the Chronic Disease Management Program/Program Pengelolaan Penyakit Kronis in primary health care, decreasing the quality of life. This study aimed to measure the quality of life of hypertensive patients undergoing the Chronic Disease Management Program at primary health care of Manado City, North Sulawesi Province, Indonesia, during the COVID-19 pandemic and determine the factors influencing hypertension such as sex, age, education, employment status, monthly income and duration of hypertension. This cross-sectional study was carried out on 150 hypertensive patients randomly sampled at primary health care from June to September 2021. The data were analyzed using the Mann-Whitney test. The quality of life of non-complicated hypertensive patients was higher than those with complications. The utility value and the visual analog scale of hypertensive patients with and without complications were 0.808±0.13 and 80.2±8.16 and 0.761±0.17 and 75.1±7.56, respectively. The quality of life of hypertensive patients without complication is better than that of hypertensive patients with complication.
ANALISIS FAKTOR RISIKO TERHADAP KEJADIAN HIPERTENSI DI PUSKESMAS RATAHAN Gloria Kapahang; Weny Indayany Wiyono; Deby Afriani Mpila
Jurnal Kesehatan Tambusai Vol. 4 No. 2 (2023): JUNI 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i2.14568

Abstract

WHO menunjukkan pada tahun 2018 sekitar 972 juta orang di dunia menderita hipertensi. Hipertensi merupakan salah satu masalah kesehatan yang perlu diwaspadai karena penyakit ini tidak menunjukan gejala atau tanda yang bisa dilihat secara langsung. Faktor-faktor yang mempengaruhi kejadian hipertensi dibagi menjadi dua, yaitu faktor yang dapat dimodifikasi dan faktor yang tidak dapat dimodifikasi. Tujuan dari penelitian ini untuk mengetahui faktor - faktor risiko yang mempengaruhi kejadian hipertensi di Puskesmas Ratahan Periode Desember 2022 – Februari 2023. Jenis penelitian ini merupakan penelitian analitik dengan desain penelitian case control. Teknik pengambilan sampel pada penelitian ini yaitu Purposive Sampling. Jumlah sampel keseluruhan 60 responden, terdiri dari 30 kelompok kasus dan 30 kelompok kontrol. Analisis data yang digunakan yaitu Chi-Square dan Spearman Rho. Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian hipertensi yaitu usia (p = 0,000), sedangkan faktor risiko yang tidak berhubungan dengan kejadian hipertensi yaitu jenis kelamin (p = 0,784), riwayat keturunan (p = 0,434), tingkat pendidikan (p = 0,196), jenis pekerjaan (p = 0,671), tingkat pendapatan (p = 1,000), konsumsi garam (p = 1,000), konsumsi alkohol (p = 1,000), aktivitas fisik (p = 1,000), obesitas (p = 1,000), kebiasaan merokok (p = 0,671), dan stres (p = 0,448). Penelitian ini menyimpulkan bahwa faktor risiko yang mempengaruhi kejadian hipertensi di Puskesmas Ratahan yaitu Usia.
ANTIBACTERIAL ACTIVITY TEST OF LAMELLODYSIDEA HERBACEA SPONGE EXTRACT FROM THE WATERS OF POOPOH VILLAGE, MINAHASA REGENCY Widya Fransiska Rompas; Defny Silvia Wewengkang; Deby Afriani Mpila
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.48915

Abstract

Infectious disease is one of the diseases that is currently became a health problem in the community. Along with the increase in cases of infection, there is also an increase in cases of resistance to antibiotics. The biodiversity of Indonesia exhibit a potential at anti-bacterial which could be develop to become antibioctics candidate. This study aims to determine the antibacterial activity of Lamellodysidea herbacea sponge obtained from the waters of Poopoh village, Minahasa Regency against the growth of Staphylococcus aureus and Pseudomonas aeruginosa bacteria. Extraction was carried by maceration out using 95% ethanol solvent. Anti-bacterial testing using agar diffusion method (Disc diffusion Kirby and Bauer). The results showed that the ethanol extracts of Lamellodysidea herbacea sponge had the largest inhibition zone on Staphylococcus aureus bacteria at a concentration of 250 μL/disc of 7.5 mm and Pseudomonas aeruginosa bacteria at a concentration of 250 μL/disc of 7.33 mm, both inhibition zones were in the medium category. Based on this study, it can be concluded that the largest inhibition zone is found in Staphylococcus aureus bacteria.  
ANTIOXIDANT ACTIVITY TEST OF ETANOL EXTRACT OF ALGA (Halimeda opuntia) TAKEN FROM THE SHORE OF POOPOH VILLAGE, MINAHASA DISTRICT Mikhael Versen Onthoni; Adithya Yudistira; Deby Afriani Mpila
PHARMACON Vol. 12 No. 3 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.49272

Abstract

Antioxidants are compounds that can protect body cells from damage caused by free radicals. Free radicals are unstable molecules that can damage body cells and cause oxidative stress. Antioxidants work by neutralizing free radicals to protect cells from damage and help maintain overall health. This study aims to test the antioxidant potential of ethanol extract of Halimeda opuntia algae taken from the southern coast of Minahasa Regency, North Sulawesi. Antioxidant activity was tested using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The decrease in absorbance value observed directly illustrates the decrease in the number of DPPH radicals remaining after the reaction between the extract and DPPH. The test results showed antioxidant levels that occurred at concentrations of 25 ppm (52.925%), 50 ppm (61.659%), 75 ppm (65.304%), and 100 ppm (70.112%). The test results show that the higher the concentration of ethanol extract of Halimeda opuntia algae, the stronger its ability to inhibit DPPH radicals. Therefore, it can be concluded that the highest antioxidant content is found at a concentration of 100 ppm with an average percent inhibition of 70.112%.
Hubungan Tingkat Kepatuhan Minum Obat dengan Kadar Gula Darah dan Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Klinik Imanuel Manado Deby A. Mpila; Weny I. Wiyono; Widya A. Lolo
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.51696

Abstract

Abstract: Effectiveness of therapy in patients with type 2 diabetes mellitus (T2DM) is strongly supported by medication adherence. This study aimed to determine the correlation between the level of medication adherence with blood glucose level and the quality of life (QoL) of patients with T2DM at the Imanuel Clinic Manado. This was an observational analytical study with a cross sectional design. Data were obtained prospectively in the period of August to September 2023 with a sample size of 45 respondents. Data of patient medication adherence were obtained using MARS-5 questionnaire; data of patient quality of life using the DQoL-BCI questionnaire; and data of blood glucose level (FPG/2-h PG) were obtained from patient medical records. The correlation between medication adherence and blood glucose levels was statistically analyzed using the chi-square test, while the correlation between medication adherence and patients’ QoL was analyzed using Spearman Rho. A p-value of <0.05 was considered statistically significant. The results showed that there were significant correlations between medication adherence and patients’ blood glucose level (p=0.017), as well as between medication adherence and patient QoL (p=0.05) with a positive correlation coefficient and moderate correlation level (r=0.294). In conclusion, medication adherence plays an important role in the management of type 2 diabetes mellitus patients to achieve blood glucose target and improved quality of life. Keywords: type 2 diabetes mellitus; medication adherence; blood glucose level; quality of life    Abstrak: Efektivitas terapi pada pasien diabetes melitus tipe 2 (DMT2) sangat didukung oleh kepatuhan minum obat. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kepatuhan minum obat dengan kadar gula darah dan kualitas hidup pasien DMT2 di Klinik Imanuel Manado. Penelitian bersifat analitik observasional dengan desain potong lintang. Data diperoleh secara prospektif pada periode Agustus–September 2023 dengan jumlah sampel sebanyak 45 responden. Data kepatuhan minum obat diperoleh menggunakan kuesioner MARS-5; data kualitas hidup pasien menggunakan kuesioner DQoL-BCI; dan data kadar gula darah (GDP, GD2PP) diperoleh dari rekam medik pasien. Hubungan antara kepatuhan minum obat dan kadar gula darah dianalisis secara statistik menggunakan uji chi-square, sedangkan hubungan kepatuhan minum obat dan kualitas hidup pasien dianalisis menggunakan Spearman Rho. Nilai p<0,05 dianggap bermakna secara statistik. Hasil penelitian menunjukkan terdapat hubungan bermakna antara kepatuhan minum obat dengan kadar gula darah (p=0,017), serta antara kepatuhan minum obat dan kualitas hidup pasien (p=0,05), dengan koefisien korelasi arah positif dan tingkat korelasi cukup kuat (r=0,294). Simpulan penelitian ini ialah kepatuhan minum obat berperan penting dalam tatalaksana terapi pasien diabetes melitus tipe 2 untuk mencapai target kadar gula darah dan perbaikan kualitas hidup. Kata kunci: diabetes melitus tipe 2; kepatuhan minum obat; kadar gula darah; kualitas hidup
Co-Authors Adithya Yudistira Alotia, Gerry S. Defny Silvia Wewengkang Gayatri Citraningtyas Gloria Kapahang Hathasary, Rochmat Hidayat Heri Wijaya Mikhael Versen Onthoni Sandeep Poddar Solang, Natasia G Subadio, Nathanael Yngwie Christian Weny I. Wiyono Weny Indayany Wiyono Weny Wiyono Widya A. Lolo Widya Astuty Lolo Widya Fransiska Rompas Wiyono, Weny I.