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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI)
Atalia Tamo Ina Bulu
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

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UJI AKTIVITAS INSEKTISIDA EKSTRAK ETANOL, FRAKSI n-HEKSAN, FRAKSI KLOROFORM, DAN FRAKSI AIR DARI BIJI PALA (Myristica fragrans Houtt) TERHADAP Anopheles aconitus Atalia Tamo Ina Bulu; Titik Sunarni; Jason Merari Peranginangin
Jurnal Farmasi & Sains Indonesia Vol 2 No 2 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

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Abstract

Nyamuk Anopheles aconitus merupakan salah satu vektor yang menularkan penyakit malaria. Salah satu cara mengendalikan populasi vektor adalah menggunakan insektisida. Tanaman obat dengan aktivitas insektisida dapat digunakan untuk mengendalikan populasi vektor malaria. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air dari biji pala (Myristica fragrans Houtt) mempunyai aktivitas insektisida yang dinyatakan dengan KC50 dan LC50. Ekstraksi menggunakan metode maserasi kemudian dilanjutkan dengan fraksinasi. Hasil ekstrasi dan fraksinasi dibuat menjadi 4 seri konsetrasi yaitu 25 ppm, 50 ppm, 100 ppm dan 200 ppm. Pengujian dilakukan terhadap 20 ekor nyamuk Anopheles aconitus. Pengamatan dilakukan selama 20 menit untuk melihat knockdown dan 24 jam untuk melihat kematian nyamuk lalu dihitung KC50 dan LC50 menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air memiliki aktivitas insektisida. Fraksi n-heksan dari biji pala (Myristica fragrans Houtt) memiliki aktivitas yang paling tinggi. Nilai KC50 berturut-turut ekstrak etanol, fraksi n-heksan, fraksi kloroform dan fraksi air adalah 527,16 ppm; 326,72 ppm; 390,01 ppm; 525,19 ppm dan nilai LC50 berturut-turut adalah 489,56 ppm; 142,66 ppm; 281,58 ppm; 364,59 ppm terhadap nyamuk Anopheles aconitus.
Pengaruh Pelarut N-Heksan, Etil Asetat, Dan Etanol 96% Terhadap Kadar Flavonoid dan Aktivitas Antioksidan Kulit Buah Lamtoro (Leucaena leucocephala) atalia tamo ina bulu; Metrikana Novembrina
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p81-86

Abstract

Lamtoro rind waste in Indonesia is produced in large quantities so it can become a problem for the environment if not managed properly. Lamtoro rind extract contains chemical compounds such as flavonoids, alkaloids, saponins, phenolics, and tannins. Flavonoid compounds, one of the phenolic groups widely found in plant tissues, can act as antioxidants. This study aims to examine the effect of N-hexane, ethyl acetate, and 96% ethanol on the levels of flavonoids and the antioxidant activity of lamtoro rind (Leucaena leucocephala). Lamtoro rind was made simplicial and extracted by maceration method using N-hexane, ethyl acetate, and 96% ethanol separately for 3x24 hours. Each extract was analyzed to determine the levels of flavonoids by UV-Vis spectrophotometry method and antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhidrazyl) method. The results of the analysis showed that 96% ethanol gave the extract with the highest levels of flavonoids, followed by ethyl acetate and N-hexane of 15.345 µg/g, 14.899 µg/g and 10.234 µg/g respectively. In addition, the antioxidant activity of lamtoro rind extract was also shown to be higher in 96% ethanol extract compared to ethyl acetate extract and n-hexane extract calculated with IC50 values of 39.914 ppm, 30.788 ppm, and 164.304 ppm respectively. Based on this study, it can be concluded that 96% ethanol resulted in lamtoro rind extract with higher levels of flavonoids and stronger antioxidant activity compared to using N-hexane or ethyl acetate as solvents. These results indicate that lamtoro rind has the potential as a useful source of flavonoids and antioxidants.
Co-Authors Jason Merari Peranginangin Metrikana Novembrina Titik Sunarni