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All Journal Indian Journal of Forensic Medicine & Toxicology Indonesian Journal Of Energy And Mineral
Hermawan
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Control & Systems Engineering Electrical & Electronics Engineering Energy Engineering Mechanical Engineering Public Health

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Effect Phenytoin Therapy to Fibroblasts and Angiogenesis of Enterocutaneous Fistula in Wistar Rat Muhammad Budiman Irpan Bachtiar; Hermawan; Hardian; Ignatius Riwanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16901

Abstract

Background: Comprehensive wound care in enterocutaneous fistula (ECF) is the therapeutic of choicecurrently, which may increase of closure rate without surgery from 19 to 92%. Phenytoin has been reportedhave anticolagenase effect on wound healing is hoped to improve the ECF closure.Aim: The study was aimed to demonstrate the effect of phenytoin on closure of enterocutaneous fistula seenfrom the number of fibroblasts and angiogenesisMethods: This study was “Randomized Controlled trial with post test only group design” on 18 malewistar rats with ECF, that were divided randomly into three groups: group(K) control, P1(topical phenytoin),P2(oral phenytoin). After 7 days of treatment, they were terminated and histopathological examinations wereperformed to do fibroblast cell counting and the amount of angiogenesis by Hematoxilin Eosin staining.Results: Mean of the number of fibroblastin groups K, P1 and P2 were 69.50 ± 10.07, 155.50 ± 13.50 and182.16 ± 11.85 respectively (One way Anova P=0.001) and mean of the number of angiogenesis in groupsK, P1, and P2 were 95.66 ± 9.72, 178.66 ± 11.75, and 205,16 ± 9.74 respectively (One way Anova P=0.001).Post Hoc Test LSD showed thatthe number of fibroblast of group P1 vs K(P=0.001), P2 vs K(P=0.001),P1 vs P2(P=0.004) and the number of angiogenesis of group P1 vs K(P=0.001), P2 vs K(P=0.001), P2 vsP1(P=0.002).Conclusion: The therapy of topical and oral phenytoin increased the number of fibroblasts and angiogenesisin Wistar rat with ECF. Out come of oral phenytoin therapy better than topical.
The Mitigation of CO2 Emissions in the Sea Water Desalination Plant with Reverse Electrodialysis Power Generation Handaja, Suka; Susanto, Heru; Hermawan
Indonesian Journal of Energy and Mineral Vol. 1 No. 1 (2021): IJoEM, Vol 1, No 1, 2021
Publisher : Politeknik Energi dan Mineral Akamigas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.017 KB) | DOI: 10.53026/IJoEM/2021/1.1/13

Abstract

Climate change is a major issue that is very interesting to discuss. Climate change is believed to be caused by the greenhouse gas effect. CO2 is one of the gases that causes the greenhouse gas effect. Therefore, to avoid the dangers of climate change, reducing CO2 emissions is the main topic in various articles. In this article, CO2 emission mitigation is analyzed in the sea water desalination plant using reverse electrodialysis power generation. Reverse electrodialysis is a power plant that does not produce CO2 emissions which converts energy from the difference in salinity of two solutions into electrical energy through selective ion membrane technology. There are 8 sea water desalination (SWD) unit which produces 242 tons/h of clean water for industrial activity and blowdown water of 3,161 tons/h, the blowdown water is wastewater. The SWD unit requires 3.043 tons/h of seawater as feed water, 0.164 MW of electricity and 86 tons/h of steam worth 64.1 MW as an energy. The energy are met from the combined heat and power operation. Combined heat and power require of fuel oil and fuel gas which produce CO2 emissions of 1,352,445,626 kgCO2/y. From the analysis on the SWD plant, the CO2 emission is 148,411,874 kgCO2/y. By implementing reverse electrodialysis power generation, blowdown water at the SWD plant which has a salinity concentration of 680 mol/m3 can produce electricity of 0.414 MW (3,636 MWh/y). If the electricity generated is used to substitute the electricity needs at the refinery plant, the CO2 emissions that can be mitigated is 2,955,915 kgCO2/y
Co-Authors Handaja, Suka Hardian Heru Susanto Ignatius Riwanto Muhammad Budiman Irpan Bachtiar