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All Journal Biomedika Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Health Sains Indian Journal of Forensic Medicine & Toxicology
Prasetyadi Mawardi
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report Danu Yuliarto; Prasetyadi Mawardi; Ambar Mudigdo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16835

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterizedby intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanindeposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to thegeneral population.Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Severalmonths ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinalcomplaints such as nausea or vomiting were previously denied. Dermatological examination in the oriset ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathologicalexamination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patienthad an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, noabnormalities were found and no signs of malignancy were found on histopathological examination.Conclusion: Result of histopathological examination showed an increase in the number of melanocytesin the stratum basale with lined melanocytes. Based on histopathological examination in this patient moreleads to the diagnosis of PJS
Secondary Syphilis in the Second Trimester Pregnancy : Case Report Wibisono Nugraha; Eka Devinta Novi Diana; Frieda; Alfina Rahma; Prasetyadi Mawardi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17670

Abstract

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, which is transmitted through sexual contact, blood transfusion and transplacental from an infected mother to the fetus. Syphilis in pregnancy can cause complications including abortion, low birth weight, premature birth, neonatal death or congenital syphilis infection.Case: A 39-year-old woman, 16 weeks pregnant, presented with a complaint of a small lump on the genitals accompanied by red patches on the palms of the hands and feet. Serological tests showed a reactive VDRL of 1:512 and a reactive TPHA of 1:640. Based on the history, physical examination and serological tests the patient was diagnosed with secondary syphilis in pregnancy. The management of this patient was given a single dose of Benzathine Penicillin G injection of 2.4 million units intramuscularly.Conclusion: Early screening for syphilis in pregnancy isvery important to prevent complications in the fetus. VDRL serological test examination 3 months after therapy was carried out to determine the success of therapy. In this case, there was a decrease in the VDRL titer to 1:4 in the absence of skin lesions 3 months after therapy with benzathine penicillin G 2.4 million units intramuscularly single dose.
GEJALA KLINIS SEBAGAI PREDIKTOR PADA KARSINOMA SEL BASAL Ratih Pramuningtyas; Prasetyadi Mawardi
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i1.261

Abstract

Basal Cell Carcinoma (BCC) incidence is 75% of all skin cancers. BCC rarely causing mortality, but morbidity is high. Clinical diagnostic is the early detection of BCC suspicion, therefore, we required specific criteria that help to establish the clinical diagnosis. The objective of this study was to know the clinical sign as a predictor of basal cell carcinoma. Ten patients with skin tumors who came to dermatovenereological department of Dr. Moewardi hospital were included in this study. Clinical diagnosis using clinical criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 (Teleangiectasion, raise border, erythematous with bleeding, pigmentation, translucent appearance, and scarlike appearance) was used as reference of clinical diagnostic criteria. Histopathological examination was performed as a gold standard. All 10 subjects had histopathological finding consistent to BCC. The clinical examination like pigmentation were found in all subjects while teleangiectasia, raise border, erythema with bleeding were found on 9 subject. Translucent appearance was found on 6 subjects. While scarlike appearance was absent in all subjects. The criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 can be used to diagnosed BCC clinicallyKeywords : Basal cell carcinoma, Clinical Diagnostic Criteria
Prognostic Factor of H-Zone Area in Basal Cell Carcinoma Prasetyadi Mawardi; Irfany Arafiasetyanto Prihadi; Muhammad Eko Irawanto
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 4, No 4 (2021): Budapest International Research and Critics Institute November
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i4.3210

Abstract

The study data were taken from secondary data obtained from medical records of BCC patients in Dr. Moewardi Hospital. The data were categorized based on gender, age, occupation, predilection/ location of tumor based on Baxter criteria, which divided the area into H-zone dan non-H-zone. H-zone was described to cover temporal, auricular, orbital, nasal, upper mandibular. Whereas the tumor size was divided into two, less than 2 cm and more than 2 cm. H-zone is a predilection with a high risk toward tumor biological characteristics, such as recurrence risk, aggressivity risk, and tumor infiltrative. The study obtained an ethics clearance from Health Research Ethics Committee of Dr. Moewardi Hospital with number 762/VIII/HREC/2021. The analysis was conducted to test whether there was a correlation or effect between two variables or more. In the study, the researcher also conducted statistics test to measure the correlation intensity of two variables or more by using Chi-square (X2), statistics test was conducted by using SPSS 22 for Windows. 99 patients were obtained from the medical records however only 70 patients who met the study requirements, who were subsequently categorized based on gender, age, occupation, BCC location and size, disease duration. 29 patients were excluded due to incomplete medical records (BCC location, BCC size, and treatment history were not found) non-primary BCC, data duplication, patients with more than one medical records, the result of histopathological test did not indicate seborrheic keratosis and Squamosa Cell Carcinoma. Based on the study there were more female patients compared to male patients. it discovered 45 female patients and 25 male patients (64,3% compared to 35,7%), with the age range was from 22-90 years, the BCC tumor was endured for more than 2 years, based on the education most of the patients had primary education background (elementary school and junior high school), the majority occupation of the patients was farmer (30%), followed by housewife (28,57%).
Multi Sistem Histiositosis Sel Langerhans pada Anak Laki-Laki Usia 2 Tahun (Tinjauan Histopatologi) Minna Hasniah; Prasetyadi Mawardi; Ambar Mudigdo; Elok Nurfaiqoh; Fitri Kasmitasari
Jurnal Health Sains Vol. 2 No. 12 (2021): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v2i12.373

Abstract

Langerhans cell histiocytosis (HSL) or histiocytosis X, eosinophilic granuloma, letterer siwe disease, hand schuller christian disease and hashimoto pritzker disease is a disorder caused by the accumulation and proliferation of langerhans cells in various organs of the body that causes tissue damage. The highest prevalence of HSL occurs in children less than 3 years old, with a ratio of 2:1 for boys and girls. The classic appearance of skin manifestations is an eruption resembling seborrheic dermatitis in the folds, axillae, scalp, retroauricular and trunk areas. The appearance of the lesion is yellow to brownish red papules, purpuric and crusted papules that can occur together with erosion. Histopathological examination with staining with S100 or cluster of differentiation 1a (CD1a) revealed Langerhans cell infiltration. The results of immunohistochemistry with IHC S-100 staining, CD1a showed a picture of Langerhans cells and histiocytes. The purpose of this paper is to study the histopathological features of HSL to better than to diagnosis and treatment of HSL. A 2-year-old boy was consulted with the chief complaint of itchy red nodules on the head, chest and back area. Complaints accompanied by diarrhea, often feel thirsty and hungry and lose weight. Dermatological status in the facial region, the anterior and posterior trunks showed lenticular papules with umbilication (pin points) with erosions covered with necrotic tissue above, on the scalp, facial, retroauricular and trunk regions, yellow to brownish papules were crusted with erosions. Histopathology with hematoxylin and eosin (HE) staining showed the presence of small fragments of skin tissue, the epidermis was partially composed intact, the dermis was filled with histiocytes, plasma cells, eosinophils, mast cell impressions and polymorphonuclear leukocytes. Immunohistochemical examination with staining IHC S-100 and CD1a showed positive. Histiocytosis is a group of disorders characterized by the accumulation of cells derived from dendritic cells accompanied by inflammation and causing tissue damage. Histopathological and immunohistochemical examinations serve to establish the diagnosis. The results of immunohistochemical examination with IHC S-100 staining, CD1a will show a picture of Langerhans cells and histiocytes
Co-Authors Alfina Rahma Ambar Mudigdo Ambar Mudigdo Danu Yuliarto Eka Devinta Novi Diana Elok Nurfaiqoh Fitri Kasmitasari Frieda Irfany Arafiasetyanto Prihadi Minna Hasniah Muhammad Eko Irawanto Ratih Pramuningtyas Wibisono Nugraha