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All Journal Biomedika Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Health Sains Indian Journal of Forensic Medicine & Toxicology
Prasetyadi Mawardi
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Indian Journal of Forensic Medicine

 1 
Peutz Jeghers Syndrome in 47 Years Old Woman (Histopathological Review) : Case Report Danu Yuliarto; Prasetyadi Mawardi; Ambar Mudigdo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16835

Abstract

Background: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder, characterizedby intestinal hamartoma polyps in association with distinct patterns of skin and mucosal macular melanindeposition. Patients with PJS have a 15-fold increased risk of developing bowel cancer compared to thegeneral population.Case: A 47-year-old woman complained of black patches appearing on the lower and upper lips. Severalmonths ago, the patient said that black patches appeared on the gums and inner cheeks. Gastrointestinalcomplaints such as nausea or vomiting were previously denied. Dermatological examination in the oriset ginggiva et buccalis region showed multiple well-defined hyperpigmented macules. Histopathologicalexamination found an increase of melanocytes in the stratum basale with rows of melanocytes. Patienthad an endoscopy in the gastrointestinal tract and histopathological examination of the colonic mucosa, noabnormalities were found and no signs of malignancy were found on histopathological examination.Conclusion: Result of histopathological examination showed an increase in the number of melanocytesin the stratum basale with lined melanocytes. Based on histopathological examination in this patient moreleads to the diagnosis of PJS
Secondary Syphilis in the Second Trimester Pregnancy : Case Report Wibisono Nugraha; Eka Devinta Novi Diana; Frieda; Alfina Rahma; Prasetyadi Mawardi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17670

Abstract

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, which is transmitted through sexual contact, blood transfusion and transplacental from an infected mother to the fetus. Syphilis in pregnancy can cause complications including abortion, low birth weight, premature birth, neonatal death or congenital syphilis infection.Case: A 39-year-old woman, 16 weeks pregnant, presented with a complaint of a small lump on the genitals accompanied by red patches on the palms of the hands and feet. Serological tests showed a reactive VDRL of 1:512 and a reactive TPHA of 1:640. Based on the history, physical examination and serological tests the patient was diagnosed with secondary syphilis in pregnancy. The management of this patient was given a single dose of Benzathine Penicillin G injection of 2.4 million units intramuscularly.Conclusion: Early screening for syphilis in pregnancy isvery important to prevent complications in the fetus. VDRL serological test examination 3 months after therapy was carried out to determine the success of therapy. In this case, there was a decrease in the VDRL titer to 1:4 in the absence of skin lesions 3 months after therapy with benzathine penicillin G 2.4 million units intramuscularly single dose.
Co-Authors Alfina Rahma Ambar Mudigdo Ambar Mudigdo Danu Yuliarto Eka Devinta Novi Diana Elok Nurfaiqoh Fitri Kasmitasari Frieda Irfany Arafiasetyanto Prihadi Minna Hasniah Muhammad Eko Irawanto Ratih Pramuningtyas Wibisono Nugraha