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Latu, Saparuddin
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulation and Evaluation of Anti-Acne Activity of Gel Pineapple Peel (Ananas comosus L.) Extract on the Growth of Propionibacterium acnes Latu, Saparuddin; Firman, Imran; Yaqkin-P, Andi Muh.; Musliani, Musliani
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.286

Abstract

Pineapple peel contains many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, alkaloids and bromelin enzymes. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acne. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the ethanol extract of pineapple peel (Ananas comosus L.) can be made into an anti-acne gel preparation and to find out at what concentration the ethanol extract of pineapple peel (Ananas comosus L.) in an anti-acne gel preparation can provide inhibitory activity on the development of Propionibacterium acne bacteria. This research method is true experimental by making anti-acne gel preparations of pineapple peel extract (Ananas Comosus L.) with various concentrations of 2%, 3%, 5% and testing the activity of the preparation against Propionibacterium acne using the agar well method. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the 5% concentration, namely 12.7 mm, which was in the strong category, while the 3% concentration, which was 11.03 mm, and the 2% concentration, which was 8.8 mm, was included in the moderate category.
Determination of Antioxidant Activity of Stem Bark (Manihot esculenta Crantz) by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Scavenging Method Latu, Saparuddin; Jangga, Jangga; Mansur, Mansur; Gajali, Nurdila
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.273

Abstract

Cassava bark is a part of the cassava plant which is still underutilized besides being used as animal feed and wasted as waste. Each cassava can usually produce 10-15% cassava bark. The amount of waste produced can cause accumulation, resulting in environmental damage if not appropriately utilized. This research aims to determine the antioxidant activity of cassava bark (Manihot esculenta Crantz) using the DPPH (1,1-diphenyl-2-pikrihidrazil) method, measured using a UV-Vis spectrophotometer. Extraction used the maceration method of 96% ethanol as solvent. The determination of antioxidants in ethanol extract of cassava bark by the DPPH method and using vitamin C was used as a reference. Vitamin C was made in four series of concentrations, namely 2, 4, 6, and 8 ppm, while the ethanol extract of cassava bark was 20, 40, 60, and 80 ppm. From several concentration series, 2 ml was taken, and 1 ml of 50 ppm DPPH was added; then, the mixture obtained was incubated for 30 minutes in a place protected from light. The absorbance was measured at a wavelength of 515 nm. The results showed that the ethanol extract of cassava bark has a potent antioxidant activity based on the IC50 value obtained, which is 3.847 mg/L. Therefore, the ethanol extract of cassava bark can be developed as a natural antioxidant.
Co-Authors Firman, Imran Gajali, Nurdila Jangga, Jangga Mansur Mansur Musliani, Musliani Yaqkin-P, Andi Muh.