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Firman, Imran
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation and Evaluation of Anti-Acne Activity of Gel Pineapple Peel (Ananas comosus L.) Extract on the Growth of Propionibacterium acnes Latu, Saparuddin; Firman, Imran; Yaqkin-P, Andi Muh.; Musliani, Musliani
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.286

Abstract

Pineapple peel contains many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, alkaloids and bromelin enzymes. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acne. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the ethanol extract of pineapple peel (Ananas comosus L.) can be made into an anti-acne gel preparation and to find out at what concentration the ethanol extract of pineapple peel (Ananas comosus L.) in an anti-acne gel preparation can provide inhibitory activity on the development of Propionibacterium acne bacteria. This research method is true experimental by making anti-acne gel preparations of pineapple peel extract (Ananas Comosus L.) with various concentrations of 2%, 3%, 5% and testing the activity of the preparation against Propionibacterium acne using the agar well method. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the 5% concentration, namely 12.7 mm, which was in the strong category, while the 3% concentration, which was 11.03 mm, and the 2% concentration, which was 8.8 mm, was included in the moderate category.
Formulasi Dan Uji Stabilitas Sediaan Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa Acuminate Linn) Sebagai Antioksidan Safaruddin; Irmayani; Kalsum, Ummu; Firman, Imran; Amin, Rahmasinar
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 3 No. 2 (2024): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v3i2.246

Abstract

Salah satu tanaman yang dapat dijadikan sebagai obat adalah tanaman Kulit Buah Pisang Muli (Musa Acuminata Linn). Daun dan kulit batang buah pisang muli dimanfaatkan sebagai obat berbagai macam penyakit, seperti pendarahan usus, amandel, memperbaiki pertumbuhan rambut. Kulit Buah Pisang Muli (Musa Acuminata Linn dapat dijadikan sediaan serum Kulit Buah Pisang Muli (Musa Acuminata Linn sebagai antioksidan, metode penelitian dilakukan secara eksperimental laboratorium, ekstrak Kulit Buah Pisang Muli (Musa Acuminata Linn) dimaserasi menggunakan pelarut etanol 96%. Dibuat sediaan serum dengan tiga konsentrasi 3%, 5%, 7%, kontrol negatif K(-), dan kontrol positif K(+) kemudian dilakukan uji organoleptis, homogenitas, pH, daya sebar, viskositas dan cycling test yang dilakukan selama 6 siklus. Hasil uji Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa acuminata Linn) dapat dijadikan sediaan serum yang stabil secara fisika dan kimia serta sediaan Serum Dari Ekstrak Etanol Kulit Buah Pisang Muli (Musa Acuminata Linn) memiliki khasiat sebagai antioksidan. Hasil penelitian menunjukkan pada formula I memiliki aktivitas nilai IC50 50,25 µg/mL, formula II memiliki aktivitas nilai IC50 30,96 µg/mL, formula III memiliki aktivitas nilai 7,85 µg/mL, sedangkan control positif memiliki aktivitas nilai IC50 13,35 µg/mL. aktivitas antioksidan dari semua sediaan memiliki sifat antioksidan yang sangat kuat karena <50 ppm kecuali formula II yang memiliki sifat antioksidan kuat karena >50 ppm.
Co-Authors Amin, Rahmasinar Irmayani Latu, Saparuddin Musliani, Musliani Safaruddin Ummu Kalsum Yaqkin-P, Andi Muh.