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Pengaruh Ekstrak Buah Jambu Biji Merah terhadap Kerusakan Struktur Histologis Hepar Mencit yang Diinduksi Asetaminofen Wardana, Vasa Adi Wisnu; ., Suyatmi; Sakiman, Bambang Sukilarso
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Antioxidants in guava fruit are vitamin C, flavanoid, and lycopene which are estimated having hepato-protective function. The objectives of this research are to know the effect of guava fruit extract and in various doses on mice liver damage induced by acetaminophen. Methods: Samples of 28 male mice, Swiss webster type, 2-3 months old age and + 20gr of each weight, were divided into 4 groups of 7 mice. Guava fruit extract was given for 14 days in a row, while acetaminophen in toxic dose was given on the 12th, 13th, and 14th day. The score of hepatocyte damage was determined by pyknosis, karyorhexis, and karyolysis. The data was analized by One-Way ANOVA test (Î±= 0,05) and continued by Post Hoc Multiple Comparisons using Least Significant Differences(LSD) test(Î±= 0,05). Results:The group with the highest average damage of hepatocyte is KP1(84,23Â±3,207), and the groups with decrease average damage of hepatocyte are KP2 (48,76Â±2,964) and KP3(35,23Â±2,755). The results of One-Way ANOVA test showed a significant difference in all group (p<0.001). The statistical data result showed a significant difference of hepatic damage between K-P1, K-KP2, K-KP3, KP1-KP2, KP1-KP3, and KP2-KP3. Conclusion: Guava fruit extract can decrease the histological damage of the hepatocyte of mice induced by acetaminophen. The higher dose of guava fruit extract, the higher protection effect againts liver histological damage from acetaminophen toxic on mice. Key words: guava fruit extract, acetaminophen, histological damage, hepatocyte.

KUALITAS PENGELOLAAN SEKOLAH LUAR BIASA ., Suyatmi
Edukasi Vol 3 No 1 (2011): edukasi : Jurnal Pendidikan Islam
Publisher : Program Studi Magister Pendidikan Islam Universitas Islam 45

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Kualitas atau mutu sangat bervariasi sehingga sulit ditentukan batasannya, termasuk kualitas pengelolaan lembaga pendidikan. Dalam lembaga pendidikan, termasuk di dalamnya sekolah luar biasa, mengenal model-model pengelolaan yang berkualitas. Salah satunya adalah model Total Quality Management. Dalam tulisan ini mencoba menjelaskan mengenai konsep kualitas dalam pengelolaan di sekolah luar biasa.

Hubungan Motivasi Berprestasi dengan Prokrastinasi Akademik pada Mahasiswa Program Studi Kedokteran Universitas Sebelas Maret Sheilla Elfira San Pambayun; Suyatmi .; Leli Saptawati
Nexus Pendidikan Kedokteran dan Kesehatan Vol 3, No 1 (2014): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Academic procrastination is an educational and psychological problem that has negative effects for students. One of the factors that influence academic procrastination is the existence of achievement motivation. Students who have a high achievement motivation level will be highly motivated to finish their homework immediately, increased their skills, and interested in challenges. This study aimed to determine the correlation between academic procrastination and achievement motivation level in Medical Student of Sebelas Maret University. Methods: This study was an observational study with cross sectional approach on October 2014 in Faculty of Medicine, Sebelas Maret University. Total sampling of 173 students were included in this study. The data were obtained using Suyatmis Achievement Motivation Scale (2002) and Ahmainis Academic Procrastination Scale. The obtained data was analyzed using Spearmans rank correlation through SPSS 20.00 for Windows. Results: This study showed the average score of achievement motivation level was 14711.20, and the average score of academic procrastination was 84.0611.86. Spearmans rank correlation test showed Spearmans correlation coefficient (r) about -0.540 with significance level = 0.000 (p < 0.05). Conclusions: There was a moderate negative correlation and statistically significant between academic procrastination and achievement motivation level in Medical Student of Sebelas Maret University. Keywords: Achievement Motivation, Academic Procrastination, Medical Students

Pengaruh Ekstrak Buah Jambu Biji Merah terhadap Kerusakan Struktur Histologis Hepar Mencit yang Diinduksi Asetaminofen Vasa Adi Wisnu Wardana; Suyatmi .; Bambang Sukilarso Sakiman
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.86 KB)

Background: Antioxidants in guava fruit are vitamin C, flavanoid, and lycopene which are estimated having hepato-protective function. The objectives of this research are to know the effect of guava fruit extract and in various doses on mice liver damage induced by acetaminophen. Methods: Samples of 28 male mice, Swiss webster type, 2-3 months old age and + 20gr of each weight, were divided into 4 groups of 7 mice. Guava fruit extract was given for 14 days in a row, while acetaminophen in toxic dose was given on the 12th, 13th, and 14th day. The score of hepatocyte damage was determined by pyknosis, karyorhexis, and karyolysis. The data was analized by One-Way ANOVA test (?= 0,05) and continued by Post Hoc Multiple Comparisons using Least Significant Differences(LSD) test(?= 0,05). Results:The group with the highest average damage of hepatocyte is KP1(84,233,207), and the groups with decrease average damage of hepatocyte are KP2 (48,762,964) and KP3(35,232,755). The results of One-Way ANOVA test showed a significant difference in all group (p<0.001). The statistical data result showed a significant difference of hepatic damage between K-P1, K-KP2, K-KP3, KP1-KP2, KP1-KP3, and KP2-KP3. Conclusion: Guava fruit extract can decrease the histological damage of the hepatocyte of mice induced by acetaminophen. The higher dose of guava fruit extract, the higher protection effect againts liver histological damage from acetaminophen toxic on mice. Key words: guava fruit extract, acetaminophen, histological damage, hepatocyte.

Hepatoprotective Effect of Ethanolic Extract of Pegagan Leaves (Centella asiatica L. Urban) on Histological Damage of Hepatocyte on Mice Model induced by Parasetamol Naila Shofwati Putri; Suyatmi .; Ratih Puspita Febrinasari
Nexus Biomedika Vol 4, No 1 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Pegagan leaves (Centella asiatica L. Urban) contain antioxidative compounds that can protect hepatocytes from free radicals. The aim of this research was to know the hepatoprotective effect of ethanolic extract of pegagan leaves (Centella asiatica L. Urban) on histological damage of hepatocyte on mice model induced by paracetamol. Methods: This study was an experimental laboratory with the post test only control group design. Samples were 30 male Swiss webster mice, with 2-3 months old and 20 gr body weight divided into 5 groups equally. KN and KI were given distilled water for 14 days. In addition, KI was also given paracetamol in dose 5.07 mg/20 gbw on the 12th, 13th, 14th day. KP1, KP2, and KP3 were given ethanolic extract of pegagan leaves in dose 5 mg, 10 mg, and 20 mg per 20 gbw respectively for 14 days and paracetamol in dose 5.07 mg per 20 gbw on the 12th, 13th, 14th day. On the 15th day, mice were sacrificed and their livers were taken for preparation with paraffin block method and stained with HE. The features of histological damage of hepatocyte were assessed by counting the numbers of nucleus damage of hepotocyte (pyknosis, karyorrhexis, karyolysis) of 100 cells in the sentrolobular zone. The data were analyzed by One-way ANOVA test and Post Hoc LSD test. \ Results: The means of histological damage of hepatocyte were 16.08 5.160; 66.00 3.275; 44.58 5.583; 31.67 2.188; 26.17 3.810 for KN, KI, KP1, KP2, KP3 respectively. The result of One-Way ANOVA test was *p = 0.000. The result of Post Hoc LSD test showed a significant difference between five groups, *p = 0.000 for KN-KI, KN-KP1, KN-KP2, KN-KP3, KI-KP1, KI-KP2, KI-KP3, KP1-KP2, KP1-KP3 and *p = 0.002 for KP2-KP3. Conclusion: The ethanolic extract of pegagan leaves can prevent histological damage of hepatocyte on mice model induced by paracetamol. Keywords: ethanolic extract of pegagan leaves, paracetamol, histological damage of hepatocyte

Bilimbi Fruit (Averrhoa bilimbi Linn.) Extract Protects Liver from Damage Induced by Reheated Palm Oil on Mice (Mus musculus) Muhammad Hilmy Labibi; Suyatmi .; Zulaika Nur Afifah
Nexus Biomedika Vol 5, No 1 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: Liver diseases such as hepatitis, cirrhosis hepatis, and fatty liver disease are serious health problem worldwide. Stress oxidative is involved in the pathogenesis of the diseases. Bilimbi fruit (Averrhoa bilimbi Linn.) contains flavonoid, triterpenoid saponin, vitamin A, and vitamin C which might protect the liver from stress oxidative. This research aimed to know the effect of Averrhoa bilimbi Linn. extract on the liver damage induced by reheated palm oil on mice. Methods: This was an experimental laboratory research with the post test only controlled group design. This research used 30 male Swiss webster mice aged 2-3 months and weighed 20 g weight divided randomly and equally into 5 groups. The normal control group (KKn) was given distilled water, the exposure group (KKp) was given reheated palm oil, and the 1st,2nd3rd treatment group (KP1, KP2, KP3) were given ethanolic extract of Averrhoa bilimbi Linn. in dose 5.6 mg, 11.2 mg, and 22.4 mg respectively. The induction for liver damage was done by giving reheated palm oil afterward. These treatments were given for 14 days. Mice were sacrificed on the 15th day by neck dislocation. The liver were obtained for preparation with paraffin block method and stained with HE. The Liver damage was assessed by quantifying of necrotic cells of each 100 cells in the centrolobular zone. Data was analyzed using One-Way ANOVA test and followed by Post Hoc test (?=0,05). Results: Mean of necrotic cells for KKn, KKp, KP1, KP2, and KP3 were 5.171.53; 78.084.74; 40.336.34; 30.176.29; and 19.005.89 cells respectively. One-Way ANOVA test showed a significant differences of liver damage score among five groups, *p=0.000. The results of Post Hoc test also showed significant difference between pairs of all group (*p =0.000). Conclusion: Averrhoa bilimbi Linn.extract protected liver from damage induced by reheated palm oil on mice. Keywords: Averrhoa bilimbi Linn. extract, reheated palm oil, liver histological damage

The Effect of Acetone Papaya Leaves Extract (Carica papaya, L.) to Hepatoprotector of Rat (Rattus novergicus) Induced by Paracetamol Dewantari Saputri; Suyatmi .; Kusmadewi Eka Damayanti
Nexus Kedokteran Translasional Vol 3, No 1 (2014): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Acetone papaya leaves extract contains chlorophyll and flavonoids with antioxidative capacity to protect the liver cell from free radicals The aims of this research were to know the hepatoprotective effect of the extract and to investigate the influence of increasing dose of the extract towards the amount of paracetamol-induced liver cells damage of rats. Methods: This study was a laboratory experimental research applying posttest only controlled group design. A total of 24 Strain Wistar rats were equally divided into 6 groups. Rats for control group (KK) and 1st group (KP1) were given aquades for 7 days. The second treatment group (KP2) was given 100mg/kg body weight (bw) of rat dose curcuma tablet. The 3rd (KP3), 4th(KP4), and 5th (KP5) treatment groups ware given acetone papaya leaves extract dose 150mg/kg bw, 300mg/kg bw, 600mg/kg bw, respectively for 7 days. Paracetamol was given to KP1, KP2, KP3, KP4, KP5 with dose 600mg/kg weight of rat on 5th, 6th, and 7th day. Finally on 8th day, rat were sacrificed by neck dislocation. After that, we made histological slides from the liver that stained with Hematoxillin Eosin (HE). The slides were observed and assessed based on the liver histological damage (pyknosis, karyorrhexis and karyolysis). Data were analized by Kruskal Wallis (? = 0,05), and continued by Mann Whithney test(? = 0,05). Results: Kruskal Wallis showed that there was a significant difference between 6 groups. Result of Mann Whithney method showed that there was a significant difference between control group (KK)and treatment group (KP1, KP2,KP4,KP5) as well as between curcuma (KP2) and acetone papaya leaves extract (KP3,KP4, KP5) groups, but there was no any significant difference between groups the increase doses (KP3-KP4,KP5). Conclusion: Acetone papaya leaves extract has hepatoprotective effect to the liver cell histological damage of rats induced by paracetamol.. Key words : acetone papaya leaves extract, paracetamol, liver cell histological damage.

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