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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. INFERENSI Berkala Ilmu Kesehatan Kulit dan Kelamin Universa Medicina ILTIZAM Journal of Sharia Economic Research JURNAL PANGAN Journal of Management and Informatics
Aunur Rofiq
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Tuberous Sclerosis Complex : A Case Report Aunur Rofiq; Lita Setyowati; Aninda Fitri Nugrahani
Saintika Medika Vol. 15 No. 2 (2019): December 2019
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol15.SMUMM2.9935

Abstract

Tuberous Sclerosis Complex (TSC) is an autosomal dominant inherited neurocutaneous disorder. Tuberous Sclerosis Complex is caused by mutations in tumor suppressor gene (TSC), both TSC1 and TSC2.  In approximately two-thirds of cases neither parent has signs of TSC and the disease is caused by a de  novo mutation. Tuberous Sclerosis Complex is classically identified by the Vort's triad in the presence of angiofibroma, mental retardation, and epilepsy. A 17-year-old woman with a major complaint of a facial bump that appeared at birth and got bigger when she reached puberty. There are white patches on the patient's body from birth. On the scalp obtained the presence of skin color plaque, while at the back and right knee obtained shagreen patch. Patientwas diagnosed with epilepsy and mental retardation by the pediatric department. No family history has the same complaints as patient. Histopathologic examination of facial bumps taken by shaving biopsy suggests the presence of hemangiomas. Based on the clinical diagnostic criteria from International Tuberous Sclerosis Complex Consensus Conference 2012, the patient meets two major criteria, macular hypopigmentation and shagreen patch so it is included in "definite diagnosis".
Kadar TNF- Lesi Kulit dengan Derajat Keparahan Psoriasis Vulgaris Sulamsih Sri Budini; M. Cholis Cholis; Aunur Rofiq
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 1 (2014): BIKKK APRIL 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.55 KB) | DOI: 10.20473/bikk.V26.1.2014.1-7

Abstract

Latar belakang: Peranan TNF- dalam patogenesis terjadinya lesi kulit pada psoriasis sudah banyak diteliti, termasuk pemakaian terapi biologis pada psoriasis dengan bahan yang menghambat TNF- dan sel T. Kegunaan TNF- serum sebagai biomarker aktifitas penyakit psoriasis memberi hasil yang tidak konsisten baik dalam jumlah absolutnya maupun hubungannya dengan respon hasil pengobatan. Tujuan: Mengevaluasi kadar TNF- lesi kulit dengan derajat keparahan penyakit psoriasis. Metode: Desain penelitian adalah potong lintang analitik observasional dengan jumlah sampel duapuluh lima penderita psoriasis vulgaris yang datang ke poli rawat jalan RSUD Dr Saiful Anwar Malang sesuai kriteria inklusi dan eksklusi. Diagnosis ditegakkan berdasarkan pemeriksaan klinis dan histopatologis. Derajat keparahan dievaluasi dengan skor Psoriasis Area Severity Index (PASI), yaitu <10 ringan; 10-20 sedang; dan >20 berat. Kadar TNF- lesi kulit di ukur dengan metode ELISA. Kadar TNF- lesi kulit ditentukan dengan menghitung nilai rerata pada masing-masing derajat keparahan. Data diolah dengan program SPSS versi 14, hubungan antara kadar TNF- lesi kulit dengan derajat keparahan penyakit diuji dengan menggunakan rumus uji korelasi Spearman. Hasil: Didapatkan rerata kadar TNF- lesi kulit 135,00 + 30,04 pada PASI ringan, 229,40 + 38,06 pada PASI sedang, 258,00 + 53,04 pada PASI berat. Rerata skor PASI penderita psoriasis vulgaris pada derajat ringan 8,57 + 0,57, sedang 16,46 + 3,08 dan berat 28,21 + 10,86. Simpulan: Makin tinggi kadar TNF- makin bertambah pula derajat keparahan psoriasis vulgaris. Kata kunci: psoriasis, TNF-, PASI, derajat keparahan.
Serum Level Of Dehydroepiandrosterone Sulphate Hormone at Various Acne Vulgaris Severity Windy Miryana; Mohammad Cholis; Aunur Rofiq; Tantari Sugiman
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.776 KB) | DOI: 10.20473/bikk.V26.3.2014.1-8

Abstract

Background: The pathogenesis of acne vulgaris (AV) is multifactorial. Hormone dehydroepiandrosterone sulfate (DHEAS) is an androgen hormone important in the initial formation of AV in women, namely the development and differentiation of sebaceous glands, which are mostly found in human blood serum. Research looking at differences in hormone levels in serum DHEAS between various degrees of severity of AV in women has not been done. Purpose: To measure whether there was a difference of serum level of DHEAS hormone at various AV severity in women. Methods: The study design was a cross-sectional analytic observational, with ninety subjects, women, by using inclusion and exclusion criterias. The diagnosis was based on clinical examination. AV severity was categorized into 3 groups, mild, moderate, and severe, that based on Combined Acne Severity Index by Lehmann. Serum level of DHEAS hormone was measured with ELISA method. The difference of serum level of DHEAS hormone at various AV severity was analyzed with non-parametric statistical test Kruskal-Wallis and Mann-Whitney. Results: The mean serum level of DHEAS hormone in women with mild AV is 1076.01±257.89 pg/ml, in moderate AV is 1971.95±272.73 pg/ml, and in severe AV is 19678.22±33536.38 pg/ml. Conclusion: There were significant difference of serum level of DHEAS hormone between women with mild and moderate AV, mild and severe AV, and moderate and severe AV (p value < 0.05), but still below from normal level.Key words: acne vulgaris, women, observasional analytic, serum level DHEAS, severity grading.
Pengembangan Potensi Lokal untuk Bahan Baku Pangan dan Industri Sebagai Usaha Meningkatkan Ketahanan Pangan Nasional Achmad Subagio; Aunur Rofiq
JURNAL PANGAN Vol. 18 No. 2 (2009): PANGAN
Publisher : Perum BULOG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33964/jp.v18i2.202

Abstract

Dengan pertumbuhan penduduk yang tinggi, sampai saat ini kecukupan kalori dan protein masyarakat Indonesia, masih rendah. Untuk itu, diperlukan penggalian sumber protein dan karbohidat alternatif, seperti ubi kayu dan koro-koroan yang tumbuh dengan baik di lahan marginal. Tulisan ini melaporkan hasil-hasil penelitian tentang pengembangan teknologi pengolahan bahan lokal sebagai bahan baku pangan dan industri, dengan mendorong keunggulannnya dan menekan kekurangannya. Penggunaan teknologi solid state fermentation dengan bakteri asam laktat menunjukkan bahwa ubi kayu dapat diolah menjadi berbagai produk baik berupa tepung termodifikasi yang sering di sebut MOCAF (modified cassava flour), maupun pati masam. Produk-produk ini mempunyai aplikasi yang lebih luas dibandingkan produk natif-nya, seperti berbagai macam mie, kue, roti dan cokies. Selanjutnya penelitian tentang korokoroan menunjukkan bahwa beberapa macam koro-koroan mempunyai kandungan protein yang cukup tinggi (17-22%) yang didominasi oleh globulin. Namun, kandungan intinutrionalfactors dan racun pada korokoroan cukup tinggi. Saat ini telah dikembangkanbeberapa produk yang menghasilkan konsentrasi protein yang tinggi dan eliminasi sifatsifat negatif koro-koroan, seperti protein isolate, "Protein Rich Flour", lactic acid-fermented legume flour, processed beans, dan tempe koro. Demikian pula, ikan-ikan inferior dapat dijadikan sebagai sumber protein yang berkelanjutan dengan pengolahan yang tepat, sehingga mendorong ketersediaan protein yang murah. Sementara kelapa dapat dijadikan sebagai bahan pangan murah mulai dari minyak, protein dan seratnya. Berdasarkan hal tersebut, kemampuan bahan lokal berdasarkan potensi komposisinya sebagai penyedia senyawa gizi merujuknya sebagai comparative dan competitive products untuk dikembangkan guna meningkatkan ketahanan pangan nasional.
Analysis The Development Marketing Strategy of Halal Tourism Facilities in Santen Island Banyuwangi Regency Saifu din; Aunur Rofiq; Ahmad Djalaluddin
ILTIZAM Journal of Shariah Economics Research Vol. 5 No. 1 (2021): Iltizam Journal of Shariah Economics Research
Publisher : Islamic Economics Department, Faculty of Islamic Economics and Business, UIN SULTHAN THAHA SAIFUDDIN JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30631/iltizam.v5i1.741

Abstract

The concept of halal tourism becomes a trend and provides opportunities for regions to develop the potential of tourism. One of them is the Banyuwangi Regency which has the potential for natural beauty and tries to develop tourist areas with the concept of halal tourism, especially on the Santen Island Banyuwangi. The purpose of this research is to describe the strategy for developing the halal tourism of Santen Island in terms of the facilities provided. The type of research used is qualitative with a descriptive approach. Data collection is obtained from interviews, observation, and documentation. The result of this study shows that the increase in internal facilities in Islamic tourism has been fulfilled from several aspects, such as separating the location of visits between men and women, building places of worship, regular notification of prayer times (azan), and the guarantee of halal food sold by traders.
Economic Empowerment through Muhammadiyah-Owned Enterprises A Case Study of Muhammadiyah Regional Board of Lumajang Imamul Hakim; Muhammad Sarif; Aunur Rofiq
INFERENSI: Jurnal Penelitian Sosial Keagamaan Vol 16, No 2 (2022)
Publisher : State Institute of Islamic Studies (IAIN) Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18326/infsl3.v16i2.195-216

Abstract

This article examines the Muhammadiyah-Owned Enterprises (Badan Usaha Milik Muhammadiyah (BUMM)) managed by CV. Syirkah Amanah and its role in the economic Empowerment of Muhammadiyah organizations and the community. CV. Syirkah Amanah is the research object because it has shown exemplary  achievements in managing BUMM. This study uses a qualitative descriptive approach with data sources through interviews, document reviews, and field observations. This study indicates that the management and development of business units owned by Muhammadiyah organizations have a significant role in the organization’s economicEmpowerment and community economic empowerment. In empowering the community’s economy, namely the existence of new job opportunities, invest and increase financial income. Meanwhile, in empowering the organization’s economy, namely increasing financial resources for the sustainability of organizational activities and increase the development of social service facilities in carrying out the organization’s vision and mission.
Effect of Physalis angulata leaf extract cream on Interleukin-4, Interleukin-6, and Immunoglobulin-E in mice with induced atopic dermatitis Dhany Prafita Ekasari; Santosa Basuki; Wuriandaru Kurniasih; Herwinda Brahmanti; Aunur Rofiq
Universa Medicina Vol. 42 No. 2 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.150-159

Abstract

BackgroundThe prevalence of atopic dermatitis (AD) and allergic or irritant contact dermatitis has been increasing significantly in the general population. Interleukin- 4 (IL-4), interleukin-6 (IL-6), and immunoglobulin E (IgE) play a key role in the pathogenesis of AD. Physalis angulata (PA) leaves reportedly have anti-inflammatory effects by impeding IL-4, IL-6, and IgE. This study aimed to evaluate the effect of PA leaf extract cream on IL-4, IL-6, and IgE using 2,4-dinitrochlorobenzene (DNCB) to induce AD-like skin inflammation in a mice model. MethodsThis study used an experimental design involving 30 BALB/c mice, that were randomized into 3 groups: 1) control group receiving no treatment; 2) Vehicle treatment group receiving vehicle cream preparation; 3) PA treatment group receiving 10% PA leaf extract cream after induction of AD-like skin inflammation by DNCB. After 30 days, tissue samples were extracted from the skin lesions to measure IL-4 and IL-6 levels, and serum to measure IgE using ELISA. One-way Anova, Kruskal-Wallis and Mann-Whitney tests were used to analyze the data. ResultsGroup 3 (PA treatment) had significantly lower IL-4 (281.15 ± 43.14 pg/mL) than group 2 (vehicle cream treatment) (388.89±135.88 pg/ml) (p=0.001). However, although IL-6 and IgE levels were lower in group 3 than in group 2, the differences were statistically not significant (p=0.096 and p=0.479 respectively). ConclusionThere were lower levels of IL-4, IL-6, and IgE in the group receiving PA leaf extract cream than in the group receiving vehicle cream preparation. Therefore, PA leaf extract cream may have therapeutic potential in AD.
MAQASHID SHARIA THINKING PERSPECTIVE OF IBNU ASSYUR IN THE DEVELOPMENT OF SHARIA BANKING Lifia Lifia; Aunur Rofiq
Journal of Management and Informatics Vol. 2 No. 1 (2023): April : Journal of Management and Informatics
Publisher : University of Science and Computer Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ibn Asyur was the second originator who made the concept of Maqashid Syariah into all scientific disciplines after Al Syathabi, in line with the journey of maqashid Syariah to become a field of knowledge. Sharia banking is also the second concept after the presence of conventional banking, but that is not a thing that prevents Islamic banking from continuing to grow and develop to spread benefits. Ibnu Asyur in his thoughts conveyed the similarity between maqashid sharia and the main objective of establishing sharia banking. Maqashid sharia in the perspective of Ibn Asyur can produce indicators of growth and development of sharia banking to be very rapid and of course still useful for Muslims and humanity in general.
Co-Authors Achmad Subagio Ahmad Djalaluddin Aninda Fitri Nugrahani Ekasari, Dhany Prafita Herwinda Brahmanti Imamul Hakim Lifia Lifia Lita Setyowati M. Cholis Cholis Mohammad Cholis Muhammad Sarif Saifu din Santosa Basuki Sulamsih Sri Budini Tantari Sugiman Windy Miryana Wuriandaru Kurniasih