Article Per Year (5 Year)
p-Index From 2019 - 2024
0.751
P-Index
This Author published in this journals
All Journal PHARMACON Jurnal Penelitian Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Aulia Nurfazri Istiqomah
Unknown Affiliation
Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN DAN BATANG SIDAGURI (Sida rhombifolia) TERHADAP MODEL HEWAN DIABETES TIPE 2 Aulia Nurfazri Istiqomah; Widhya Aligita; Hendra Mahakam Putra; Denny Galang; Hapipah Nurjamilah
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1410

Abstract

Diabetes is a disease characterized by increased levels of glucose in the blood that occur due to a lack of insulin production or the cessation of insulin production in the body. Sidaguri herb (Sida Rhombifolia) is known to have antidiabetic activity. This study was conducted to evaluate the antidiabetic activity of the ethanolic extract of the leaves and stems of sidaguri (Sida rhombifolia) in animal of type 2 diabetes model and to find out which part is the most effective as antidiabetic. This research method is an in vivo experimental study. Mice were divided into 9 groups, that is negative control group, positive control group, Glibenclamide 0.65 mg/KgBW, sidaguri leaf extract at a dose of 3.5; 7; and 14 mg/KgBW, as well as sidaguri stem extract at a dose of 3.5; 7; and 14 mg/KgBW. The test was carried out curatively, the test animals except negative controls were given induction of alloxan monohydrate 80 mg/KgBW via the intravenous route, then after 3 days post-induction, fasting blood glucose levels were checked. The treatment was continued by giving therapy for 14 days via the oral route. The test parameters in this study were the measurement of blood glucose levels on days 0, 7, and 14, and pancreatic histopathology was also performed. The test results show that was found that the extract that gave the best antidiabetic effect was the ethanolic extract of sidaguri leaves at a dose of 14 mg/KgBW but had not been able to fully improve the condition of the pancreatic cells
AKTIVITAS ANTIOBESITAS DAN ANTIINFLAMASI EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L.) Merr) PADA TIKUS WISTAR JANTAN OBESITAS Aulia Nurfazri Istiqomah; Hendra Mahakam Putra; Widhya Aligita; Betti Risa O
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1059

Abstract

Obesity is currently a disease with a prevalence that continues to increase every year and is a significant risk factor for cardiovascular disease. The relationship between obesity and inflammation is characterized by increased levels of TNF- which triggers inflammation. This study was conducted to determine the activity of katuk (Sauropus androgynus (L.) Merr) leaves as anti-obesity and anti-inflammatory properties. The study was conducted with a preventive method on white male wistar rats aged 2-3 months and body weight of 180-200 g. The test animals were divided into 6 groups that were induced by high-fat and carbohydrate diets except the normal group and were measured for anti-obesity and anti-inflammatory parameters. The results showed that katuk (Sauropus androgynus (L.) Merr) leaves can maintain activity as an anti-obesity and anti-inflammatory in test rats. Katuk leaf ethanol extract at a dose of 300 mg/kgBW has an effective activity as an anti-obesity, while at a dose of 150 mg/kgBW it has an anti-inflammatory activity.
REVIEW AKTIVITAS ANTIHIPERTENSI TANAMAN CARICA PAPAYA Yermia Ademi Dedeo; Aulia Nurfazri Istiqomah; Agus Sulaeman
PHARMACON Vol. 11 No. 3 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kardiovaskular adalah Penyakit tidak menular yang menyerang masyarakat di negara maju hingga negara berkembang seperti Indonesia, salah satu dari penyakit kardiovaskular adalah hipertensi yang disebut sebagai penyumbang kematian terbanyak di dunia setiap tahunnya, seorang dengan tekanan darah abnormal dapat mengalami beberapa penyakit seperti gagal jantung, gagal ginjal, diabetes dan stroke. Tujuan dari penelitian ini untuk mengetahui potensi Carica Papaya dalam penanganan hipertensi dan perkembangan penelitian terhadap potensi Carica Papaya. Subjek review ini adalah artikel nasional dan internasional yang terindeks secara nasional dan international 10 tahun terakhir yang membahas kemampuan antihipertensi pada Carica Papaya dengan melakukan klasifikasi berdasarkan metode pengujian yang digunakan, mekanisme kerja senyawa kimia yang berperan aktif dalam aktivitas hipotensi dan bagian tumbuhan yang digunakan dalam pengujian. Pada studi literatur didapatkan bahwa Carica Papaya memiliki berbagai mineral dan metabolit sekunder yang mampu menurunkan tekanan darah melalu mekanisme yang mirip dengan obat konvensional, Carica Papaya memiliki senyawa saponin, alkaloid, flavonoid dan kalium yang mampu menurunkan tekanan darah dengan mekanisme vasodilatasi, ACE Inhibitor dan diuretik. Carica Papaya memiliki kemampuan antihipertensi yang baik pada seluruh bagian tumbuhan namun perlunya studi lebih lanjut secara spesifik pada senyawa aktif dan mekanisme kerja yang belum diteliti.
AKTIVITAS ANTIOBESITAS DAN ANTIINFLAMASI EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus (L.) Merr) PADA TIKUS WISTAR JANTAN OBESITAS Aulia Nurfazri Istiqomah; Hendra Mahakam Putra; Widhya Aligita; Betti Risa O
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1059

Abstract

Obesity is currently a disease with a prevalence that continues to increase every year and is a significant risk factor for cardiovascular disease. The relationship between obesity and inflammation is characterized by increased levels of TNF- which triggers inflammation. This study was conducted to determine the activity of katuk (Sauropus androgynus (L.) Merr) leaves as anti-obesity and anti-inflammatory properties. The study was conducted with a preventive method on white male wistar rats aged 2-3 months and body weight of 180-200 g. The test animals were divided into 6 groups that were induced by high-fat and carbohydrate diets except the normal group and were measured for anti-obesity and anti-inflammatory parameters. The results showed that katuk (Sauropus androgynus (L.) Merr) leaves can maintain activity as an anti-obesity and anti-inflammatory in test rats. Katuk leaf ethanol extract at a dose of 300 mg/kgBW has an effective activity as an anti-obesity, while at a dose of 150 mg/kgBW it has an anti-inflammatory activity.
Co-Authors Agus Sulaeman Betti Risa O Denny Galang Hapipah Nurjamilah Hendra Mahakam Putra Widhya Aligita Yermia Ademi Dedeo