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Vevi Maritha
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology

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HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ASSAY OF METAMIZOLE, THIAMINE AND PYRIDOXINE IN TABLET Vevi Maritha
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.791 KB) | DOI: 10.31001/jfi.v13i2.281

Abstract

The aim of the present study was develop and validate HPLC method for the simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Metamizole is a substance that is easily hydrolyzed in the presence of water and oxygen. To inhibit the hydrolysis of metamizole during sample preparation prior to HPLC analysis. Sodium sulfite is added and its optimum concentration was investigated. The chromatographic system includes a RP C8(2) column (150x4.6 mm, 5 µm particle size) in conjunction with Photo Diode Array (PDA) detector. The optimal chromatographic condition was obtained using a mobile phase consisting of phosphate buffer 35mM pH 3.0: methanol (80:20), flowrate 1.0 mL/min, and 10 µl injection volume. The metamizole, thiamine and pyridoxine were detected at 275 nm. The hydrolysis of metamizole was successfully inhibited by adding solution containing 1.5 mg/mL sodium sulfite to solvent and 0.5 mg/mL sodium sulfite to mobile phase. The validation results indicate a good specificity and a linear detector responses with r>0.999. The accuracy (% recovery) for metamizole, thiamine and piridoxine were 100.26%; 99.09%; and 100.03%, respectively. The method yields good precision with RSD of metamizole, thiamine and pyridoxine were 2.0912%; 1.4489%; and 0.8418%, respectively. The validated method was successfully applied for simultaneous assay of metamizole, thiamine and pyridoxine in tablet.
ANALISIS RHODAMIN-B PADA LIP CREAM YANG BEREDAR DI APLIKASI BELANJA ONLINE SECARA KROMATOGRAFI CAIR KINERJA TINGGI rofi'atul fauziah; Yetti Hariningsih; Vevi Maritha
Duta Pharma Journal Vol. 1 No. 1 (2021): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.748 KB) | DOI: 10.47701/djp.v1i1.1188

Abstract

Lip cream adalah salah satu jenis lipstik yang memiliki karakteristik liquid dan diaplikasikan pada bibir untuk menentukan bentuk dan memberi warna serta perlindungan terhadap lingkungan sekitar bibir. Rhodamin-B adalah zat warna sintetis yang memiliki bentuk serbuk kristal, tidak berbau, berwarna merah keunguan. Tujuan dari penelitian ini untuk mengetahi panjang gelombang maksimal dari Rhodamin-B, kondisi optimum metode analisis Rhodamin-B secara Kromatografi Cair Kinerja Tinggi serta mengetahui kadar Rhodamin-B pada sampel lip cream yang beredar di aplikasi belanja online. Penelitian ini dilakukan di Laboratorium Kimia Terpadu STIKES Bhakti Husada Mulia Madiun. Penelitian ini menggunakan 3 sampel lip cream yang dijual di aplikasi belanja online. Penentuan panjang gelombang maksimal dilakukan pada rentang panjang gelombang 400-800 nm. Penetuan kondisi optimum dilakuakan pada panjang gelombang maksimal terpilih, fase diam kolom C18, panjang kolom 250 mm, ukuran partikel 5 μm, detektor visible, laju alir 1 ml/menit, volume injeksi 20 μL, dan komposisi fase gerak menggunakan methanol: air: asetonitril. Sampel lip cream di ekstraksi selama 2 jam, kemudian di saring dan di injeksikan pada kolom KCKT. Hasil penelitan penentuan Panjang gelombang maksimal Rhodamin-B adalah 554 nm, kondisi optimum KCKT untuk analisis Rhodamin-B laju alir 1 ml/menit, volume injeksi 20 μL, panjang gelombang 554 nm dengan fase gerak methanol: asetonitril: air (47:47:6), fase diam kolom C18, suhu 25 oC, serta memenuhi syarat kesesuaian sistem. Kandungan Rhodamin-B yang terdapat pada sampel lip creambuntuk sampel A sebesar 2,023 ± 0,1880, sampel B sebesar 1,100 mg/L ± 0,0177 dan sampel C sebesar 5,101 mg/L ± 0,531. Kata kunci: Rhodamin-B, lip cream, Kromatografi Cair Kinerja Tinggi (KCKT)
Co-Authors rofi'atul fauziah Yetti Hariningsih