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All Journal Radioterapi & Onkologi Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Alida R Harahap
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Physics Other

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NILAI RUJUKAN FREE LIGHT CHAIN SERUM DENGAN IMUNOTURBIDIMETRI Lidya Utami; Riadi Wirawan; Alida R Harahap; Abdul Muthalib; Harny Edward
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1006

Abstract

The light chains of immunoglobulin are produced in larger quantity rather than heavy chains, therefore small amount of free lightchains (FLC) can be found in the blood of healthy individuals. Free light chain production is increased in the clone’s proliferation ofmalignant B cells, i.e. in myeloma. Therefore the FLC level measurement can be used for diagnosis aid of myeloma and related B cellsdisorders. The aim of this study is to establish reference range of serum FLC κ, FLC λ, and κ/λ ratio in population ≥40 year’s old usingimmunoturbidimetry assay. Serum FLC κ, FLC λ and κ/λ ratio were measured in 240 healthy male and female attending medical checkup in MMC hospital. Healthy subjects were determined by anamnesis and physical examination, with routine haematology, ESR, andserum creatinine level within normal ranges. The serum FLC assays were performed in the Clinical Pathology Laboratory, RSCM, usingHitachi 912 with immunoturbidimetry method. The results were analyzed by SPSS 11.5 program. Serum FLC normal reference valuein 40-84 years old healthy subjects are: FLC κ 11.7–30.6 mg/L, FLC λ 9.7–25.0 mg/L, and κ/λ ratio 0.79–1.75. This research is thefirst study for finding serum FLC values in the Indonesian population. The normal reference value found is similar with another studyusing the same platform analyzer.
Rasio Malondialdehyde Katalase Sebelum dan Sesudah Radiasi sebagai Prediktor Persentase Pengecilan Volume Tumor pada Pasien Kanker Serviks Stadium Lanjut Lokal Aida Lufti Huswatun; Soehartati Argadikoesoema Gondhowiardjo; Alida R Harahap; Joedo Prihartono
Radioterapi & Onkologi Indonesia Vol 5, No 1 (2014): Volume 5 No.1 Januari 2014
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.729 KB) | DOI: 10.32532/jori.v5i1.20

Abstract

Pada keganasan terjadi stres oksidatif, yang ditandai dengan peningkatan kadar serum malondialdehyde (MDA) dan aktivitas antioksidan enzim katalase yang rendah. Penelitian ini merupakan kohort prospektif pada 30 pasien kanker serviks lanjut lokal di Departemen Radioterapi RS CiptoMangunkusumo periode Juli sampai September 2013. Pemeriksaan kadar MDA dan aktivitas enzim katalase dilakukan sebelum dan sesudah radiasi fraksi ke 15, menggunakan spektrofotometri. Respons terapi berdasarkan kriteria WHO dengan membandingkan persentase ukuran volume tumor sebelum radiasi dan 4 minggu setelah radiasi komplit. Pada penelitian ini ditemukan peningkatan serum MDA (p<0,001) dan penurunan aktivitas enzim katalase (p<0,001) setelah fraksi ke 15. Ditemukan korelasi yang signifikan antara rasio MDA katalase sesudah fraksi ke 15 dengan presentase pengecilan tumor 4 minggu setalah radiasi komplit (r=0.689, p=0.001). Penelitian ini menunjukan terjadi stres oksidatif pada pasien kanker serviks lanjut lokal, yang ditandai dengan peningkatan kadar serum MDA dan penurunan aktivitas enzim katalase. Rasio MDA katalase sebelum dan sesudah radiasi fraksi ke 15 dapat menjadi prediktor persentase pengecilan tumor 4 minggu pasca radiasi komplit.
Co-Authors Abdul Muthalib Aida Lufti Huswatun Harny Edward Joedo Prihartono Joedo Prihartono Lidya Utami Riadi Wirawan Soehartati Argadikoesoema Gondhowiardjo