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Pengaruh Suplementasi Vitamin A pada Pengobatan Pasien TB Paru terhadap Percepatan Konversi Dahak pada Fase Intensif Di Wilayah Kerja Puskesmas Kecamatan Medan Kota Alexander Marpaung; Parluhutan Siagian; Dina Keumala Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.343 KB) | DOI: 10.35814/jifi.v16i2.512

Abstract

Indonesia is the second rank for the most TB (Tuberculosis) cases in the world after India. It’s estimated there are a million cases per year in Indonesia. The objective of the research was to find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. This research applied clinical testing design with experimental approach and Experimental Quasi method. The samples were 30 newly diagnosed pulmonary TB patients consisting of 15 patients in the treatment group and 15 patients in the control group. They were ≥ 18 years old, regularly consumed category I OAT with BMI ≥ 18.5. The statistical data were analyzed by Mann-Whitney statistical testing at reliability rate 95% (p < 0.05). The results of the research on the treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputumconversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase (p = <0.001) < (alpha = 0.05). Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. speed up wound healing on second degree burns. White egg gel had significantly difference compared to negative control of NaCl 0.9% and no signifi cantly difference compared to Bioplacenton as positive control.
ELEVATED SERUM S100B PROTEIN LEVEL AS A PARAMETER FOR BAD OUTCOME IN SEVERE TRAUMATIC BRAIN INJURY PATIENTS Ridha Dharmajaya; Dina Keumala Sari; Ratna Akbari Ganie
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1159

Abstract

Beratnya suatu cedera kepala akibat trauma akan membuat gangguan saraf pusat. Kerusakan saraf ini dapat dinilai dengan petandabiokimia yang tepat. Pemakaian petanda biokimia terhadap kerusakan otak mendapatkan perhatian yang banyak terutama ProteinS100B. Protein S100B adalah suatu ikatan kalsium dan protein yang meningkat cepat sesaat setelah cedera kepala. Kesulitannya adalahuntuk memastikan, berapa lama Protein S100B ini harus diukur. Jika berhubungan dengan kerusakan otak, ia tidak selalu terjadi pada24 jam pertama. Dapat terjadi pada 48–72 jam pasca cedera kepala, bahkan 120 jam pada kecederaan tersebut. Penelitian ini bertujuanuntuk mendapatkan kenasaban antara Protein S100B dengan GOS sebagai faktor peramalan yang akurat, mudah, tidak menyakitkan,untuk cedera kepala berat. Pengambilan serum darah untuk pemeriksaan kadar Protein S100B dilakukan pada 24, 48, 72 dan 120 jampasca trauma. Selanjutnya pengukuran dilakukan dengan menggunakan Enzyme Linked Immunosorbent Assay (ELISA). Keluaran pasienpasca perawatan dinilai menggunakan penggolongan Glasgow Outcome Scale (GOS), tiga bulan pasca kecederaan. Hasil pengukurankadar Protein S100B pada 120 jam pasca cedera kepala berat menunjukkan hubungan berlawanan yang kuat terhadap keluaran pasien.Pasien cedera kepala berat dengan kadar Protein S100B 120 jam pasca trauma yang tinggi, memiliki hasil keluaran yang buru