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All Journal Best Journal (Biology Education, Sains and Technology) Al-MIKRAJ: Jurnal studi Islam dan Humaniora
Nasution, M. Pandapotan
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Public Health Social Sciences

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Skrining Fitokimia Dan Uji Sitotoksisitas Ekstrak Etanol Biji Anggur (Vitis vinifera L.) Dengan Metode BSLT (Brine Shrimp Lethality Test) Asriningtyas, Kinanti; Nasution, M. Pandapotan
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.5640

Abstract

Cancer is an abnormal state of cells, which is the leading cause of death worldwide after cardiovascular disease and is expected to reach 12 million deaths by 2030. There are various kinds of plants that can be used as anti-cancer treatment, one of which is grape seeds (Vitis vinifera L.). Grape seeds contain 74–78% oligometric proanthocyanidins and grape seed extract contains flavonoids. Proanthocyanidins of grape seeds are a group of polyphenols. The objective of this research was to determine the content of grape seeds and determine the level of toxicity of LC50 using the BSLT (Brine Shrimp Lethality Test) method. The research was conducted using the BSLT (Brine Shrimp Lethality Test) method by calculating the number of deaths of Artemia salina larvae with Lethal concentration parameters 50 (LC50). Grape seed extract variation, chemical content, characterization and cytotoxicity tests were variables in the research. The results of phytochemical screening testing showed that red grape seeds were positive for alkaloids, flavonoids, saponins, tannins, and steroids. The results of cytotoxicity test with probit analysis showed an LC50 value of 367.2823 μg / mL so that it can be concluded that red grape seed ethanol extract is toxic and has the potential to be anticancer.
Aktivitas Antibakteri Ekstrak Etanol Daun Ruku-Ruku (Ocimum tenuiflorum L.) Terhadap Bakteri Staphylococcus epidermidis Alaina, Nadila; Mambang, Elysa Putri; Nasution, M. Pandapotan; Nasution, Haris Munandar
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.8107

Abstract

Daun ruku-ruku (Ocimum tenuiflorum L.) merupakan salah satu tanaman obat yang dikenal masyarakat digunakan sebagai bumbu masakan karena aromanya yang dapat mengurangi bau tidak sedap. Berdasarkan kandungan kimianya, daun ruku-ruku banyak mengandung alkaloid, flavonoid, tanin, saponin dan steroid/triterpenoid. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun ruku-ruku terhadap bakteri Staphylococcus epidermidis. Metode penelitian dilakukan secara eksperimental dengan variabel bebas yaitu ekstrak etanol daun ruku-ruku dengan konsentrasi 5%, 10% dan 20% sedangkan variabel terikatnya adalah aktivitas antibakteri terhadap Staphylococcus epidermidis. Ekstrak sederhana daun ruku-ruku dibuat dengan pelarut etanol 96%. Kontrol positif yang digunakan adalah Tetrasiklin dan kontrol negatif adalah DMSO. Pengujian yang dilakukan terhadap simplisia daun ruku-ruku meliputi pemeriksaan fitokimia, pemeriksaan makroskopis, pemeriksaan mikroskopis, pemeriksaan kadar air, pemeriksaan nira larut air, pemeriksaan kadar sari larut etanol, pemeriksaan kadar abu dan pemeriksaan kadar abu tidak larut asam. Hasil skrining fitokimia menunjukkan bahwa daun ruku-ruku (Ocimum tenuiflorum L.) mengandung senyawa metabolit sekunder yaitu alkaloid, flavonoid, tanin, saponin dan streroid/triterpenoid. Hasil penelitian aktivitas antibakteri menunjukkan bahwa daun ruku-ruku dapat digunakan sebagai antibakteri karena mempunyai daya hambat yang kuat pada konsentrasi 5%, 10% dan 20% yaitu 8,7 mm, 9,8 mm dan 12,1 mm terhadap bakteri Staphylococcus epidermidis
Co-Authors Alaina, Nadila Asriningtyas, Kinanti Mambang, Elysa Putri Nasution, Haris Munandar