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All Journal Jurnal Pembelajaran dan Biologi Nukleus Indonesian Journal of Pharmaceutical and Clinical Research Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi
Ginting, Junius Gian
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Antifungal Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Trichophyton rubrum and Pitysporum ovale Ginting, Junius Gian; Hasibuan, Poppy Anjelisa Zaitun; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 2 (2021): Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) Vol. 04, No
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i2.6295

Abstract

Abstract. Wounds that are not treated and are kept open will provide an entrance for microorganisms from outside that can cause infection. One of the medical needs whose demand continues to increase is wound dressings. Chitosan is known to have wound healing activity by stimulating the formation of new tissue, and silver nanoparticles have good antimicrobial activity. Silver nanoparticles and chitosan with cellulose nanofibers carrier are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles are 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0 then tested the antifungal activity against Trichophyton rubrum and Pitysporum ovale for finding the best formula for antifungal activity. The analysis showed that the patch with a ratio of 6:4 had the best antifungal activity against Trichophyton rubrum (14.7±0.1 mm) and a 9:1 patch on the Pitysporum ovale (6.9±0.05 mm) gave a significant difference to negative control (p<0.05). It can be concluded that the Patches Silver Nanoparticle and Chitosan with Cellulose Nanofibers (SNCCN) carriers have good antifungal activity in the inhibitory category.
Uji Efektivitas Gel Ekstrak Daun Jarak Pagar (Jatropha Curcas L.) sebagai Penyembuhan Luka Sayat Vera Estefania Kaban; Ginting, Junius Gian; Nasri, Nasri; Sagala, Hasel Untung Bersinar; Tarigan, Serly Annisa Br
INSOLOGI: Jurnal Sains dan Teknologi Vol. 3 No. 4 (2024): Agustus 2024
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v3i4.3975

Abstract

Indonesia is known for having abundant biological riches and many plants that can be used as medicine. One of the medicinal plants that is often used by Indonesian people is Jatropha curcas leaves. Jatropha plants are currently used as traditional medicine to treat wounds. One common medication used for cuts is povidone iodine which is effective against bacterial infections. However, povidone iodine also has side effects such as irritation, toxic reactions and burning skin. Jatropha leaves have strong antioxidant activity, so it is necessary to innovate in wound treatment using natural ingredients in the form of gel preparations. The gel preparation was chosen because it is practical, not sticky, easily absorbed by the skin, and works directly on wound tissue. The aim of this study was to assess how well a gel made from ethanol extract of jatropha leaves accelerates the healing of cut wounds in white mice. Jatropha curcas leaves were extracted using the maceration method using 96% ethanol as the solvent. Gel stability testing was carried out organoleptically, homogeneity test and spreadability test. Jatropha leaf extract gel was tested on mice that had been given incisions 1.4 cm long with formulations of 10%, 15% and 20% jatropha leaf extract concentrations. Observations were carried out for seven days. Research findings showed that giving white rats gel containing jatropha leaf extract significantly accelerated their ability to repair wounds
PENYULUHAN TENTANG PENYAKIT KECACINGAN PADA ANAK DI DESA UJUNG LABUHAN KECAMATAN NAMORAMBE Sinaga, Sahat; Sihombing, Ismadi; Kemala, Sarma Dewi; Barus, Syafril; Ginting, Junius Gian; Purba, Hermawan
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 4 (2024): Volume 5 No. 4 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i4.33282

Abstract

Kecacingan adalah infeksi cacing usus yang sering disebabkan oleh cacing gelang, cacing cambuk dan cacing tambang. Penyebaran infeksi cacing dapat disebabkan oleh masuknya makanan, minuman yang terkontaminasi dengan telur cacing kemudian masukkan cacing dari permukaan kulit melalui vektor cacing yang terdapat pada tanah. Infeksi cacing dapat memberikan dampak terhadap pertumbuhan dan perkembangan anak, anemia, lemas, mengantuk, malas belajar, IQ menurun, prestasi dan produktivitas menurun, terganggunya perkembangan fisik dan mental serta kekurangan gizi. Kegiatan pengabdian berupa penyuluhan tentang penyakit kecacingan pada anak di desa ujung labuhan kecamatan namorambe yang dilaksanakan pada hari senin, 03 Juni 2024. Peserta yang hadir terdiri dari 30 anak yang didampingi oleh ibunya. Kesimpulan kegiatan menunjukkan adanya pemahaman pada ibu tentang pentingnya menjaga kebersihan diri dan lingkungan yang dapat dilihat dari antusias para ibu dalam sesi tanya jawab. Selain itu, kegiatan ini memberikan manfaat secara langsung maupun tidak langsung karena telah menambah wawasan terkait dampak buruk akibat penyakit kecacingan sehingga para ibu berupaya untuk mencegah penyakit kecacingan memalui Tindakan kebersihan diri dan lingkungan.
Inhibition Test of Ethanol from Extract Mangosteen Leaves (Garcinia mangostana L.) as an Acne Antibacterial Ginting, Junius Gian; Br. Singarimbun, Nurbaiti; Daeli, Mestika Clemesiya Yulianti; Simanjuntak, Helen Anjelina; Purba, Hermawan; Br. Barus, Lydia; Zega, Defcato Firmawati
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5066

Abstract

A prevalent global infection that manifests frequently in Indonesia. An example of an infectious disease that is commonly encountered during adolescence is acne (Acne vulgaris). Antibiotics can be used to treat acne; however, their misuse can lead to the development of resistance; therefore, we are searching for inexpensive, readily available alternatives that are also secure. Mangosteen leaves (Garcinia mangostana L.) are one alternative to synthetic ingredients when it comes to the treatment of acne. Mangosteen leaves comprise xanthone derivative compounds that exhibit significant biological activity, including antioxidant, antibacterial, and antimicrobial properties. Therefore, this this study aimed to ascertain the inhibitory power of an ethanol extract derived from mangosteen leaves in order to determine its antibacterial activity against Staphylococcus epidermidis bacteria. Additionally, the compound content of the ethanol extract of mangosteen leaves was determined. The inhibition test was conducted by utilizing the paper disc technique, while the extraction method employed the maceration method. As indicated by the phytochemical screening test results, simplicia and ethanol extract of mangosteen leaves were found to contain steroids/triterpenoids, alkaloids, flavonoids, saponins, and tannins. The inhibition test outcomes against Staphylococcus epidermidis bacteria revealed the following: a diameter of 3.3 mm for bacteria at a concentration of 20%, 9.4 mm for bacteria at 40%, 10.4 mm for bacteria at 60%, 12.9 mm for bacteria at 80%, and 13.2 mm for bacteria at 100%
The Utilisation of Coconut Water Waste into Nanocellulose and Potential Synergistic Effect of Asthma Plant (Euphorbia hirta L.) Extract as an Antibacterial Agent Barus, Lydia Br; Manihuruk, Fani Nuryana; Sari, Mesi Puspita; Simanjuntak, Helen Anjelina; Ginting, Junius Gian; Purba, Hermawan
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5060

Abstract

Skin infections contribute to one of the most significant global health issues. Acne, blisters, and abscesses are examples of skin infections that can be induced by Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Treatment can be attempted through the development of nanotechnology in the form of nanocellulose. Nanocellulose, an organic substance, can be produced through the conversion of coconut water waste and Acetobacter xylinum bacteria. Future applications of nanocellulose formulated with a blend of extracts derived from natural sources, including Patikan Kebo (Euphorbia hirta L.), are anticipated to include the treatment of wound dressings (patches). Determining the antibacterial potential of nanocellulose was the objective of this study. The experimental research technique is implemented in phases. The extraction process was conducted by means of maceration, while the parallel streak method was utilized for antibacterial testing. The findings of the study indicated that the mean zone of inhibition for each treatment variable was as follows: 0 mm, 15.1 mm, 23.53 mm, and 23.06 mm for nanocellulose (serving as the negative control), nanocellulose and 0.5% extract, 1% extract, 1.5% extract, and clindamycin, respectively. Conclusion: Antibacterial activity was observed in nanocellulose extracts containing 1% and 1.5%
Co-Authors Barus, Lydia br Barus, Syafril Br. Barus, Lydia Br. Singarimbun, Nurbaiti Daeli, Mestika Clemesiya Yulianti Hasibuan, Poppy Anjelisa Zaitun Helen Anjelina Simanjuntak Kemala, Sarma Dewi Manihuruk, Fani Nuryana Nasri Nasri, Nasri Purba, Hermawan Sagala, Hasel Untung Bersinar Sari, Mesi Puspita Sihombing, Ismadi Sinaga, Sahat Tarigan, Serly Annisa Br Vera Estefania Kaban Yuandani Zega, Defcato Firmawati