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All Journal CHEMISTRY PROGRESS Jurnal Farmasi Sains dan Komunitas (JFSK)
Rizky H. Mawardi
Ahmad Dahlan University
Chemistry Medicine & Pharmacology

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AKTIVITAS ANTIOKSIDAN DARI FRAKSI TONGKOL JAGUNG (Zea mays L.) YANG DIINDUKSI OLEH Fe2+ DAN CAHAYA UV-B Mawardi, Rizky H.; Suryanto, Edi; Sudewi, Sri
CHEMISTRY PROGRESS Vol 9, No 1 (2016)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.9.1.2016.13906

Abstract

This research aims to study the anti UV-B activity from solvent fractions of corncobs. The study initiating by extracting the powder corn cobs using way reflux for two hours with 80% ethanol. Extract then partitioned using a series of solvent; n-hexane, ethyl acetate, butanol and distilled water. Then was determined the effect of fractions against lipid oxidation induced by UV-B light. The results showed that the ethyl acetate fraction showed the lowest content of conjugated diene followed fraction of butanol, n-hexane and distilled water. The content of conjugated diene was 21.89; 25.11; 42.94; and 46.08 mmol/kg, respectively. Based on this study, the fraction of ethyl acetate fraction could act as an antioxidant and anti UV-B better than the other fractionsPenelitian ini bertujuan untuk mempelajari aktivitas anti UV-B dari fraksi pelarut tongkol jagung. Penelitian dimulai dengan mengekstraksi serbuk tongkol jagung menggunakan cara refluks selama dua jam dengan pelarut etanol 80%. Ekstrak kemudian dipartisi berturut-turut menggunakan pelarut n-heksan, etil asetat, butanol, dan aquades. Kemudian ditentukan pengaruh fraksi terhadap oksidasi lipid yang diinduksi dengan cahaya UV-B. Hasilnya menunjukkan bahwa fraksi etil asetat memiliki kandungan diena terkonjugasi terendahdiikuti fraksi butanol, n-heksan dan aquades. Kandungan diena terkonjugasi berturut-turut adalah 21,89; 25,11; 42,94; dan 46,08 mmol/kg. Berdasarkan penelitian ini, dapat disimpulkan bahwa fraksi etil asetat dapat berperan sebagai antioksidan dan anti UV-B lebih baik dibandingkan dengan fraksi lainnya.
ANTIBACTERIAL ACTIVITY AND TLC-BIOAUTOGRAPHY ANALYSIS OF THE ACTIVE FRACTIONS OF Muntingia calabura L. LEAVES AGAINST Staphylococcus aureus Rizky H. Mawardi; Nanik Sulistyani; Nurkhasanah Nurkhasanah; Ricke Desyratnaputri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.228 KB) | DOI: 10.24071/jpsc.002362

Abstract

This study aims to determine the antibacterial activity and TLC-bioautography profile of the active fractions of Muntingia calabura L. leaves against Staphylococcus aureus. Muntingia calabura L. leaves were macerated with ethanol 96% then fractionated with n-hexane, ethyl acetate, and methanol solvent, respectively. The antibacterial activity was tested by the Kirby-Bauer method to determine the most active fraction and the lowest concentration that inhibited the growth of Staphylococcus aureus. TLC-bioautography was tested using chloroform: ethyl acetate (2:8) as the mobile phase and silica gel F254 as the stationary phase. Antibacterial activity test of n-hexane and ethyl acetate fractions at a concentration of 10% w/v showed activities with inhibition zone diameter of 0.330.288 and 9.665.77 mm, respectively. At the same time, the methanol fraction showed no activity. The lowest concentration of ethyl acetate fraction which still showed the inhibition zone was 0.312% w/v. The TLC-bioautography profile showed active spots with an Rf value of 0.82 and had an inhibitory zone diameter of 4.0130.864 mm. It can be concluded that the ethyl acetate fraction was the most active fraction that inhibited the growth of Staphylococcus aureus and had one active spot on the bioautography test.
Co-Authors Edi Suryanto Nanik Sulistyani Nurkhasanah Nurkhasanah Ricke Desyratnaputri Sri Sudewi, Sri