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All Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Indian Journal of Forensic Medicine & Toxicology
Dwi Adi Nugroho
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Religion Arts Humanities Economics, Econometrics & Finance Public Health Social Sciences

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Cardiac Fibrosis Attenuation by Chlorogenic Acid and Epigallocatechin-Gallate Mediated by Suppression of Galectin-3 Gene Expression and Collagen Deposition in Rat Metabolic Syndrome Model Indah Nur Chomsy; M. Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Husnul Khotimah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14759

Abstract

Objective: Metabolic syndrome (MetS) is a set cluster of risk factors for metabolic abnormalities thatcan develop cardiovascular disease (CVD), one of that is remodeling or cardiac fibrosis. Cardiac fibrosisidentified from the high levels of the profibrotic molecule; one of them is galectin-3. Aim: This studyintended to determine the effect of combination therapy of green coffee (CGA) and green tea (EGCG) oncardiac fibrosis by raise of the galectin-3 gene expression and collagen deposition in rat cardiac tissue inthe rat metabolic syndrome model. Methods: Twenty-four male MetS rats (Sprague-Dawley) divided intotwo control groups and three groups therapy (n=5) administration of the CGA 200mg/kgbw (body weightin kilograms) and EGCG 300mg/kgbw orally. After eight weeks of treatment, rats euthanized, then mRNAexpression of galectin-3 was measured. Furthermore, collagen deposition of cardiac tissue carried out inhistology slides. Results: Research reveals that the expression of galectin-3 decreased in the metabolicsyndrome model group, which given combination therapy compared with metabolic syndrome model micethat did not receive any therapy (P=0.000). Collagen deposition in cardiac tissue also found less than inthe therapy group compared with the group not treated with both compounds (P=0.000). The correlationbetween the two parameters shows a positive association with low strength. Conclusion: This study showsthat the combination therapy of CGA and EGCG is an engaging therapeutic candidate. It expected to reducethe progression of cardiac fibrosis in metabolic syndrome
Consumer Perceptions and Preferences of Beverage Products in Malang City Mohammad Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Nashi Widodo; Inggita Kusumastuty; Nur Ida Panca Nugrahini
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.3872

Abstract

This research aims to investigate the consumer perceptions and preferences of beverage products in Malang City, East Java. This study uses a Mixing theory approach, which analyzes research data quantitatively by using descriptive analysis, and qualitatively. The population is all consumers of beverage products in Malang city, where 220 consumers were selected as research samples through purposive random sampling. Primary data were collected using a questionnaire. Types of drinks that are commonly consumed by the local community include soft drinks, tea, milk, coffee, health drinks, and beverages included in "other" category. Furthermore, the most consumed beverage is coffee. The results demonstrate that the choice of beverage products is greater based on the health and refreshing benefits. In terms of purchasing methods, most consumers prefer buying directly at the nearest store. This finding is a strong signal for beverage producers to market the products widely to reach small stores in residential areas. Producers of beverages other than coffee are suggested to emphasize the refreshing or health benefits of the beverage products to gain consumers' preference.
Co-Authors HUSNUL KHOTIMAH Indah Nur Chomsy Inggita Kusumastuty M. Saifur Rohman Mifetika Lukitasari Mohammad Saifur Rohman Nashi Widodo Nur Ida Panca Nugrahini