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All Journal Ilmiah Manajemen Bisnis Nusantara Medical Science Journal Jurnal Biomedika Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Ilmiah Inspiratif
Arif Santoso
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Prevalence of Listeria spp. with PRS Genes in Fresh Vegetables from Traditional Markets A. Kaisar Adiwijaya Putra; Rizalinda Sjahril; Arif Santoso; Dianawaty Amiruddin; Andi Alfian Zainuddin; Firdaus Hamid
Biomedika Vol 13 No 2 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i2.842

Abstract

Listeriosis is a foodborne infectious disease caused by Listeria monocytogenes and is considered a serious health problem, due to the severity of symptoms and a high mortality rate in worldwide This study aims to identify and determine the prevalence of Listeria species through prs gene screening of fresh vegetables distributed in several markets of Makassar City. A total of 57 fresh vegetable samples were collected from February to May 2019 in four traditional markets Makassar. The isolates is examines to phenotypically and genotypically Vitek and Multiplex PCR with prs and lmo1030 primer. Phenotype analysis did not show the presence of Listeria species, but the results of genotypic was found 8 positive prs gene samples (14.03%), consisting of 31.2% long beans, 18.2% cabbage, and 9.1% cucumber and. All Listeria species found in this study is Listeria monocytogenes. This study also provide information and additional data that prs genes can be used as screening genotype for identify Listeria species in fresh vegetables.
Pendekatan Pengawasan Internal dalam Pencegahan Fraud: Peran Moderator Audit Intern Iman Kadarman; Meiliani Meiliani; Arif Santoso
Ilmiah Manajemen Bisnis VOL. 19, NO. 2 JULI - DESEMBER 2019
Publisher : Ilmiah Manajemen Bisnis

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Abstract

Abstract — The phenomenon of fraud in the government becomes a challenge for the effectiveness of internal control to reduce the risk of the threat. Since COSO identifes informal and formal aspects within the framework of the internal control, soft control and hard control are two internal control approaches that need to be applied. The presence of the internal audit is a function that cannot be ignored in strengthening the internal control system. This study aimed to investigate the role of internal audit of the effect of soft control and hard control on the fraud prevention of fnancial statements in the Local Government of Bengkulu City. One hundred and forty-fve fnancial management offcials at OPD Bengkulu City were surveyed. The results of data analysis show that (1) the soft control partly has a signifcant effect on the fraud prevention, only on the commitment on competence, and the responsibility and authority delegation; (2) the hard control partly and signifcantly influences the fraud prevention only on the performance review, the information system control, and the documenting; (3) the internal audit moderates partly the effect of the soft control on the fraud prevention only on the commitment on competence, the responsibility and authority delegation; the assurance activity, the consulting activity, the commitment on competence and assurance activity, and positive leadership and the assurance activity; and (4) the internal audit partly moderates the effect of the hard control on the fraud prevention on the performance review, the information system control, and the. Discussion and implication are discussed. Keywords— Financial statement, Fraud, Hard control, Internal audit, Soft control
Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy Nasrawati Basir; Yulia Yusrini Djabir; Arif Santoso
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.13450

Abstract

Introduction:  The first-line regimen for tuberculosis (TB) treatment comprises Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, these drugs are known to potentially cause hepatotoxicity. This study aimed to evaluate hepatotoxicity incidence in patients during intensive phase of anti-tuberculosis treatment focusing on post-incidence therapy. Methods:  The study involved pulmonary TB patients who were admitted to the National Lung Health Center due to hepatotoxicity after receiving fixed-dose combination of antituberculosis drugs (FDC-AT) in September-October 2019. Drug-related hepatotoxicity is defined as an increase in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 2.5 times of the normal upper limit (ULN) with an increase in bilirubin level. Results:  There were 8 patients admitted to the center due to hepatotoxicity, 4 of them experienced grade 3 (severe) hepatotoxicity, during which the ALT, AST, bilirubin levels increased 5-10 times of the ULN. The post-hepatotoxicity treatment includes the cessation of FDC-AT treatment followed by hepatoprotective supplements. Following two weeks of treatments, the biomarker levels of two out of four patients went back to normal and the AT therapy was resumed. Meanwhile, the other two patients continued to receive the hepatoprotective therapy for up to 8 weeks. However, when the treatment failed to bring the transaminase level back to normal, a different AT regimen was prescribed. Conclusions: The cessation of FDC-AT and the use of hepatoprotective supplements for two to eight weeks were able to alleviate the AT-induced severe hepatotoxicity. A close monitoring of liver biomarkers is warranted to prevent the incidence of hepatotoxicity in patients receiving antituberculosis
The survival rate comparison of non small cell lung carcinoma patients who are given by epidermal growth factor receptor-tyrosin kinase inhibitor and those given by first-line chemotherapy treatment Hasan Nyambe; Arif Santoso; Nur Ahmad Tabri; Harun Iskandar; Muh Ilyas; Edward Pandu Wiriyansyah
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18857

Abstract

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the  study is     discontinued. Result. From 239 subject of NSCLC patients consisted of 135 patients who receive first-line chemotherapy, and 104 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are more than 40 years old (chemotherapy 124 (91.9%) and EGFR-TKI 101 (97.1%) with the male gender that dominates (chemotherapy 98 (72.6%), EGFR-TKI 64 (61.5%). Smoking patients who received first-line chemotherapy are 65.2% and 61.5% of EGFR-TKIs with chemotherapy highest IB (severe IB 28.9%) and for EGFR-TKI (moderate IB are 26.9%). 73.2% of adenocarcinoma histology type with a predominance of stage IV 86.6% (83.7% for chemotherapy and EGFR-TKI 90.4%). Survival rate of patients are 98,7% for 6 months survival, 1 year survival rate is 94.1% and 2 years survival rate of 24.3%. Median survival patients who receiving EGFR-TKI longer than they received first- line chemotherapy (21 months versus 20 months). The 18 months PFS showed that patients treated with EGFR-TKI were 15 months, while patients receiving chemotherapy was 11 months. (P 0.000). Conclusion. Survival rates in NSCLC patients with EGFR-TKI therapy had significantly the highest survival rates compared with all other chemotherapy. Progression was faster in patients with first-line chemotherapy than EGFR-TKI. The factors that most influence the survival rate is type of therapy with p value<0.05.
PENGARUH PEMBERIAN MINYAK BIJI JINTEN HITAM TERHADAP KADAR INTERLEUKIN-6 PADA PEROKOK AKTIF SEHAT Arif Santoso; Akrom Akrom; Laela Hayu Nuraini; Titiek Hidayati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.385 KB) | DOI: 10.36387/jiis.v7i1.861

Abstract

Exposure to cigarette smoke causes cellular oxidative stress and is the key to the inflammatory process in the lungs. Black cumin seed oil (MBJH) is one of the traditional medicines that is proven to contain the active substances timoquinone, nigelon and negelin which have antioxidant and immunomodulatory effects. Interleukin-6 (IL-6) is a proinflammatory cytokine and a multifunctional cytokine that is very important for determining the immune response, cell survival, apoptosis and proliferation and is a protumorogenic agent in many cancers. The purpose of this study was to determine the levels of IL-6 in healthy active smokers after being given MBJH at a dose of 0.5 ml/capsule. The research design used was a single blind Randomized Controlled Trial (RCT). A total of 39 healthy healthy active smokers were divided into 4 groups: Group 1 was given a placebo 3x1 capsules/day, group 2 was given MBJH 3x1 capsules/day, group 3 was given MBJH 3x2 capsules/day and group 4 was given MBJH 3x3 capsules/day. The placebo and MBJH interventions were administered for 30 days. Statistical analysis obtained showed that there was no significant difference in the mean levels of IL-6 between the treatment group and the placebo group with p>0.05. The results showed that the use of MBJH for 30 days can reduce the average level of Interleukin-6 but not significantly in healthy active smokers.
Correlation of low body mass index and albumin level with the presence of liver dysfunction in newly diagnosed tuberculosis patients Sriyanty Sadsyam; Yulia Yusrini Djabir; Arif Santoso
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.49 KB) | DOI: 10.29303/sjp.v2i2.105

Abstract

Tuberculosis (TB) patients often experience reduced appetite or nutritional malabsorption leading to malnutrition, which manifests in excessive loss of muscle mass and low body mass index (BMI). Patients with protein malnutrition is associated with increased risk of drug-induced liver injury and may require a close monitoring during the course of antituberculosis (AT) treatment. The purpose of this study was to determine the correlation of low body mass index and albumin level with liver dysfunction in patients newly diagnosed with TB prior to receiving AT drugs. This study is a nonexperimental observational study with consecutive sampling technique by following a descriptive analytic design (cohort study). The subjects were patients in the National Lung Health Center Makassar who are newly diagnosed with TB and have not received any AT drug. The BMI data and blood samples were collected and analyzed to obtain Alanine aminotransferase (ALT), Aspartat aminotransferase (AST), and Albumin levels. It was found that out of 22 total patients, 3 (14%) of the TB patients experienced liver dysfunction characterized by high level of ALT and AST levels. Both patients had normal levels of albumin despite one of them had a low BMI. The statistical showed no correlation between the low BMI or albumin level with the presence of liver dysfunction. It is concluded that the presence of liver dysfunction is not correlated with low BMI or albumin level in newly diagnosed TB patients, and hence, are not considered as independent risk factors of liver dysfunction in this population.
PENGARUH PAJAK DAERAH DAN RETRIBUSI DAERAH TERHADAP TINGKAT KEMANDIRIAN KEUANGAN DAERAH DENGAN BELANJA MODAL SEBAGAI VARIABEL Mulkan Teguh Sutrisno; Arif Santoso
Majalah Ilmiah Inspiratif Vol 7, No 13 (2021): Majalah Inspiratif Vol.7 No.13 Juli 2021
Publisher : Universitas Pandanaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.359 KB)

Abstract

Tujuan penelitian ini adalah  untuk memberikan bukti empiris pengaruh  Pajak Daerah dan Retribusi Daerah terhadap Tingkat Kemandirian Keuangan Daerah dengan Belanja Modal sebagai variabel intervening pada Kabupaten/Kota di Jawa Timur. Metode analisis yang digunakan dalam penelitian ini adalah metode kuantitaitif dengan pengujian regresi berganda dengan melakukan uji asumsi klasik sebelum mendapatkan model penelitian terbaik. Variabel dalam penelitian ini adalah Pajak Daerah dan Retribusi daerah sebagai variabel independen dan Belanja Modal sebagai variabel dependen. Jumlah populasi penelitian ini seluruh Laporan Realisasi Anggaran (LRA) Kabupaten/kota di Provinsi Jawa Timur yang berjumlah 38 kabupaten dan kota, dengan menggunakan teknik sensus sebagai sampel dari tahun 2015 sampai dengan tahun 2019. Hasil dari penelitian ini adalah : Pajak Daerah dan Retribusi Daerah  berpengaruh positif signifikan terhadap Belanja Modal, Pajak Daerah berpengaruh positif signifikan terhadap Tingkat Kemandirian Keuangan Daerah dan Retribusi daerah dan Belanja Modal tidak berpengaruh signifikan terhadap Tingkat Kemandirian Keuangan Daerah pada kabupaten/kota di Propinsi Jawa Timur.  Kata Kunci : Pajak Daerah, Retribusi Daerah, Belanja Modal dan Tingkat Kemandirian Keuangan Daerah
Co-Authors A. Kaisar Adiwijaya Putra Akrom, Akrom Andi Alfian Zainuddin Dianawaty Amiruddin Edward Pandu Wiriyansyah Firdaus Hamid Harun Iskandar Hasan Nyambe Iman Kadarman Laela Hayu Nurani Meiliani Meiliani Muh Ilyas Mulkan Teguh Sutrisno Nasrawati Basir Nur Ahmad Tabri Rizalinda Sjahril Sriyanty Sadsyam Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Yulia Yusrini Djabir