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Cytotoxicity of Kelakai (Stenochlaena palustris) Extract to MCF-7 Breast Cancer Cell Harlyanti Muthma'innah Mashar; Itma Annah
Jurnal Fitofarmaka Indonesia Vol 7, No 3 (2020): JURNAL FITOFARMAKA INDONESIA (English Edition)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i3.590

Breast cancer is reported to rank fifth among all types of cancer with a case of death of 6.6%. In the Central Kalimantan region, early examinations of cancers including breast cancer were carried out and 247 tumors in the breast were identified (1.76%). Kelakai (Stenochlaena palustris) as one of the typical plants of Kalimantan which contain natural chemical constituents has been reported to be effective as an anti-inflammatory and antioxidant, so that with this potential can be developed to overcome diseases associated with it, one of them is breast cancer. This study aimed to examine the cytotoxicity of MCF-7 breast cancer cells using ethanol extract. The cytotoxicity assay of kelakai extract against MCF-7 cells conducted in vitro by the MTT reduction method. The variation of concentration used is 1000; 500; 250; 125; 62.5; 31.5; and 15.625 µg/ml, doxorubicin as a positive control was performed in a concentration of 1 μg / ml. The results of the cytotoxicity assay showed that the kelakai extract had a toxic effect on MCF-7 cells with an IC50 value of 493.57 µg / ml.

STATUS PERNIKAHAN DAN DUKUNGAN SOSIAL SUAMI TERHADAP KUALITAS HIDUP WANITA MENOPAUSE DI KOTA PALANGKA RAYA Itma Annah; Harlyanti Muthma’innah Mashar
Jurnal Surya Muda Vol 2 No 1 (2020): Jurnal Surya Muda
Publisher : LPPM STIKES Muhammadiyah Kendal

Menopause is a period of permanent cessation of the menstrual cycle, causing decreased production of the hormones estrogen, progesterone and testosterone. Some of the symptoms of menopause are hot flashes, night sweats, and vaginal atrophy resulting in vaginal dryness associated with changes in sex hormone levels resulting in decreased quality of life for menopausal women. The purpose of this study is to look at the relationship between marital status and husband's social support to the quality of life of menopausal women in Palangka Raya City. The instrument used to assess the quality of life of menopausal women is to use The Utian Quality of Life (UQOL) Scale. The research method used is a cross sectional study design. The results showed there was a relationship between marital status and the quality of life of menopausal women (p = 0,000), as well as husband's social support (p = 0,000). Therefore, it is very important that there is family support especially the husband in providing social support for menopausal women.

Perbedaan Kualitas Hidup Wanita Menopause Daerah Urban dan Rural Itma Annah; Harlyanti Muthma’innah Mashar; Irene Febriani; Destinady Kadiser Miden
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 11 No 2 (2021): April 2021
Publisher : LPPM STIKES KENDAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v11i2.1228

Diperkirakan secara global angka populasi wanita berumur 50 tahun atau lebih akan meningkat menjadi 1,2 milyar pada tahun 2030. Yang berarti adanya peningkatan angka harapan hidup pada wanita maka akan berpengaruh pula pada banyaknya wanita yang akan mengalami menopause pada sepertiga hidupnya. Kejadian menopause berhubungan dengan perubahan kadar hormon seks sehingga mengakibatkan penurunan kualitas hidup wanita menopause. Tujuan penelitian ini ialah untuk melihat perbedaan kualitas hidup wanita menopause di derah urban dan rural Kota Palangka Raya, dan melihat faktor-faktor yang berhubungan dengan kualitas hidup Instrumen yang digunakan untuk menilai kualitas hidup wanita menopause adalah menggunakan The Utian Quality of Life (UQOL) Scale. Populasi dalam penelitian ini adalah seluruh kunjungan pasien menopause di Puskesmas Menteng dan Puskesmas Kereng Bangkirai. Peneliti menggunakan sampel minimal size dengan perhitungan sampel 30/kelompok. Tehnik pengambilan sampel adalah dengan menggunakan metode accidental sampling. Metode penelitian yang digunakan ialah uji t tidak berpasangan untuk membandingkan kualitas hidup wanita menopause daerah rural dan urban dan desain studi cross sectional untuk melihat faktor-faktor yang berhubungan dengan kualitas hidup wanita menopause. Hasil penelitian menunjukkan ada perbedaan kualitas hidup wanita menopause daerah rural dan urban (perbedaan nilai mean= 14,28 dan p =0,007), dan faktor yang berhubungan dengan kualitas hidup wanita menopause adalah tingkat pendidikan (p=0,015), riwayat penyakit responden (p=0,000). Dapat disimpulkan bahwa ada perbedaan kualitas hidup daerah urban dan rural, yang mana kualitas hidup wanita menopause daerah urban cenderung lebih baik dibandingkan daerah rural.

INFORMASI KESEHATAN REPRODUKSI TERHADAP PERILAKU BERPACARAN REMAJA DI PROVINSI KALIMANTAN TENGAH, INDONESIA ITMA ANNAH; WAHIDAH SUKRIANI; IRENE FEBRIANI
Journal of Nursing and Public Health Vol 10 No 2 (2022)
Publisher : UNIVED Press, Universitas Dehasen Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pendahuluan: Masa remaja merupakan masa yang unik dalam perkembangan manusia dan masa terpenting dalam menjaga kesehatan. Pada masa remaja terjadi perubahan fisik dan seksual yang signifikan sehingga ketertarikan seksual terhadap lawan jenis dan dorongan seksual juga berkembang. Perilaku seksual pranikah yang dilakukan oleh remaja mulai dari yang berisiko ringan seperti berpelukan dan berpelukan atau yang berisiko tinggi seperti berciuman dan berhubungan seks. Penelitian ini bertujuan untuk menganalisis paparan informasi kesehatan reproduksi remaja terhadap perilaku berpacaran remaja di Provinsi Kalimantan Tengah. Metode: Penelitian ini menggunakan metode deskriptif analitik dengan menganalisis data SKAP 2018 dengan unit analisis untuk Provinsi Kalimantan Tengah. Analisis data menggunakan SPSS Versi 22 untuk melihat pengaruh paparan informasi kesehatan reproduksi remaja terhadap perilaku berpacaran remaja dengan analisis bivariat menggunakan chi square. Hasil dan Pembahasan: Faktor umur, pendidikan dan tingkat kesejahteraan berhubungan dengan perilaku pacaran remaja di Kalimantan Tengah (p < 0,05). Usia Remaja Akhir, Pendidikan Tinggi dan Tingkat Kesejahteraan Menengah dan Bawah memiliki peluang lebih tinggi untuk terlibat dalam perilaku berkencan yang berisiko. Ada hubungan antara perolehan informasi luar ruang dengan perilaku berpelukan, ciuman, dll (p < 0,05), namun analisis risiko menunjukkan efek protektif. Remaja yang mendapatkan informasi dari luar memiliki peluang 3,38 kali untuk mencium, memeluk, dll dibandingkan dengan remaja yang tidak mendapatkan informasi.Kesimpulan: Diharapkan ada standar (Rambu) informasi KRR yang diberikan baik melalui media luar ruang, petugas, maupun Lembaga. Pelaksanaan Pelatihan Rutin terhadap para Guru tentang Kesehatan Reproduksi Remaja terkait hasil penelitian menunjukkan presentase terbesar informasi Kesehatan reproduksi dari petugas terbesar dari guru serta pemanfaatan Social Media seperti Facebook, Twitter, Instagram sebagai sarana pemberian informasi.

Faktor-Faktor yang Mempengaruhi Keputusan Jajan Sembarangan pada Anak di Sekolah Dasar Negeri Tengket 1 Kabupaten Bangkalan Wahidah Sukriani; Itma Annah; Herlinadiyaningsih Herlinadiyaningsih; Siti Hapsah Pahira
Jurnal Forum Kesehatan : Media Publikasi Kesehatan Ilmiah Vol 11 No 2 (2021): Agustus 2021
Publisher : POLITEKNIK KESEHATAN KEMENKES PALANGKA RAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52263/jfk.v11i2.228

Abstract – Maintaining health from an early age is important to do. Nutrition has an important role in the growth and development of a child. The habit of eating snacks at school is a habit that almost all students do at school. However, the importance of children's snacks at school is not supported by the nutritional content in the food consumed by students. Objective: to find out the factors that influence the habit of random snacks in children. Methods: This research method uses descriptive quantitative research methods, using a cross section study research design with data collection techniques carried out using a random survey of 20 elementary school children. Results: (1) The breakfast variable has a positive and insignificant relationship, (2) the variable knowledge of nutrition in food and (3) bringing supplies to school has a negative and significant relationship to the decision to consume random snacks, (4) the influence of variables X1, X2 , and X3 to Y of 42.32% while 57.68% is influenced by other variables outside the model. Conclusion: The variables of knowledge (X2) and carrying provisions (X3) have a significant influence on reducing students' decisions to consume random snacks at school.

Faktor-Faktor yang Mempengaruhi Keputusan Jajan Sembarangan pada Anak di Sekolah Dasar Negeri Tengket 1 Kabupaten Bangkalan Wahidah Sukriani; Itma Annah; Herlinadiyaningsih Herlinadiyaningsih; Siti Hapsah Pahira
Jurnal Forum Kesehatan : Media Publikasi Kesehatan Ilmiah Vol 11 No 2 (2021): Agustus 2021
Publisher : POLITEKNIK KESEHATAN KEMENKES PALANGKA RAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52263/jfk.v11i2.228

Abstract – Maintaining health from an early age is important to do. Nutrition has an important role in the growth and development of a child. The habit of eating snacks at school is a habit that almost all students do at school. However, the importance of children's snacks at school is not supported by the nutritional content in the food consumed by students. Objective: to find out the factors that influence the habit of random snacks in children. Methods: This research method uses descriptive quantitative research methods, using a cross section study research design with data collection techniques carried out using a random survey of 20 elementary school children. Results: (1) The breakfast variable has a positive and insignificant relationship, (2) the variable knowledge of nutrition in food and (3) bringing supplies to school has a negative and significant relationship to the decision to consume random snacks, (4) the influence of variables X1, X2 , and X3 to Y of 42.32% while 57.68% is influenced by other variables outside the model. Conclusion: The variables of knowledge (X2) and carrying provisions (X3) have a significant influence on reducing students' decisions to consume random snacks at school.

Analisis Jalur Determinan Sindrome Premenstruasi pada Remaja Putri Destinady Kadiser Miden; Irene Febriani; Itma Annah
JURNAL KESEHATAN PRIMER Vol 7 No 2 (2022): JKP (Jurnal Kesehatan Primer)
Publisher : Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/jkp.v7i2.916

Background: Premenstrual Syndrome (PMS) is the most common health problem reported by women of reproductive age. The incidence of PMS is caused by several factors, such as stress factors, diet, sleep patterns, physical activity, and body mass index (BMI). This study aims to analyze the pattern of variable relationships that directly affect or indirectly affect a set of independent variables (exogenous) to the dependent variable (endogenous). Methods: This study was a quantitative survey of high school girls in Palangka Raya City. The sampling technique used is clustered random sampling followed by stratified random sampling. Results: Some variables had a significant direct effect on the incidence of PMS, including BMI, stress, diet, and physical activity. In addition, some variables indirectly affect the incidence of PMS through BMI variables, namely stress and physical activity. Conclusion: There is a significant relationship between both direct and indirect effects of exogenous variables on endogenous variables. It is hoped that the results of this study can reduce the incidence of PMS in adolescents both in the education and health sectors.

ANALISIS KADAR FLAVONOID TOTAL FRAKSI ETIL ASETAT KULIT BATANG SIRSAK (Annona muricata L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Harlyanti Muthma'innah Mashar; Itma Annah; Dali; Teguh Supriyono
Jurnal Kefarmasian Akfarindo Vol 8 No 1 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i1.161

Pendahuluan: Sirsak merupakan tanaman yang memiliki buah dengan kandungan nutrisi dan senyawa kimia yang telah banyak digunakan untuk pengobatan tradisional, dan kaya akan senyawa antioksidan. Aktivitas antioksidan ini dapat menghambat stres oksidatif. Aktivitas antioksidan tersebut terkait dengan kandungan senyawa kimia yang tinggi pada berbagai bagian tubuh tumbuhan ini. Klika sirsak mengandung berbagai senyawa, salah satunya adalah flavonoid. Flavonoid memiliki efek biokimia dan antioksidan yang banyak dimanfaatkan untuk meningkatkan kesehatan. Berbagai penelitian melaporkan bahwa flavonoid memiliki potensi sebagai anti inflamasi, anti alergi, antivirus, antikarsinogenik, serta terapeutik dan sitotoksik. Tujuan: Penelitian ini bertujuan untuk menganalisis kadar flavonoid total ekstrak etil asetat klika sirsak dengan metode spektrofotometri UV-VIS. Metode: Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol, dan dilanjutkan dengan proses partisi dengan pelarut etil asetat sehingga diperoleh ekstrak etil asetat. Analisis kadar flavonoid total dilakukan dengan metode spektrofotometri UV-Vis menggunakan larutan baku rutin pada konsentrasi 10, 20, 30, dan 40 ppm. Absorbansi larutan baku rutin dan ekstrak diukur pada Panjang gelombang 415 nm. Hasil: Hasil ekstraksi dengan pelarut etanol dan dilanjutkan dengan proses partisi dengan pelarut etil asetat diperoleh ekstrak etil asetat sebanyak 1,6 g dan nilai rendemen sebesar 10,67%. Hasil analisis kadar flavonoid total sampel dan didapatkan hasil yaitu kadar flavonoid total dari ekstrak etil asetat klika sirsak adalah 118,266 mg ER/g dengan persentase 11,8266 %. Kesimpulan: Ekstrak etil asetat klika sirsak positif mengandung flavonoid dan sebanyak 1 mg/mL sampel mengandung flavonoid total sebesar 118,266 mg ER/g dengan persentase 11,8266 %.

Efektivitas Model Pendampingan Pemeriksaan Payudara Sendiri (SADARI) Remaja Putri SMAN-1 Katingan Tengah triska febriyani; Seri Wahyuni; Itma Annah
Jurnal Forum Kesehatan : Media Publikasi Kesehatan Ilmiah Vol 13 No 1 (2023): Pebruari 2023
Publisher : POLITEKNIK KESEHATAN KEMENKES PALANGKA RAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52263/jfk.v13i1.153

The World Health Organization (WHO) in 2018 stated that 61.16% of 103 or around 63 women aged 10-24 years died in Indonesia due to breast cancer. Central Kalimantan Province in 2017 experienced an increase in the discovery of tumors/lumps in the breast from originally 82 people (1.54%) from a sample of 5,313 people in 2016 to 247 people (1.76%) from a sample of 14,063 people in 2017. City of Palangka Raya in 2018 , in early detection of breast cancer there was an increase in 2018 by 8 cases (0.018%) of 444 samples. This study aims to determine characteristics including age, level of education and employment, known average knowledge of BSE before and after intervention using an application, and a more effective breast examination assistance model by measuring the level of BSE knowledge in adolescents at SMAN-1 Katingan Tengah. This research is a research that uses a descriptive method with data analysis used is univariate and bivariate with a two-mean difference test and statistics. The research sample consisted of 30 young women and 30 parents (mothers) using a random sampling technique. The results showed that most of the young women had good knowledge before the intervention of 30.0% with an average of 13.17 and after being given intervention through the application increased to 100% with an average of 19.07 and some parents (mothers) had good knowledge before the intervention 20, 0% with an average of 12.63 and after being given intervention through family assistance increased to 100% with an average of 17.97. Comparison of the average value after the intervention of the effectiveness of the breast self-examination assistance model (BSE) by group with a difference of 1.1. And it is proven statistically where the value is (p = 0.000).

Efektivitas Model Pendampingan Pemeriksaan Payudara Sendiri (SADARI) Remaja Putri SMAN-1 Katingan Tengah triska febriyani; Seri Wahyuni; Itma Annah
Jurnal Forum Kesehatan : Media Publikasi Kesehatan Ilmiah Vol 13 No 1 (2023): Pebruari 2023
Publisher : POLITEKNIK KESEHATAN KEMENKES PALANGKA RAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52263/jfk.v13i1.153

The World Health Organization (WHO) in 2018 stated that 61.16% of 103 or around 63 women aged 10-24 years died in Indonesia due to breast cancer. Central Kalimantan Province in 2017 experienced an increase in the discovery of tumors/lumps in the breast from originally 82 people (1.54%) from a sample of 5,313 people in 2016 to 247 people (1.76%) from a sample of 14,063 people in 2017. City of Palangka Raya in 2018 , in early detection of breast cancer there was an increase in 2018 by 8 cases (0.018%) of 444 samples. This study aims to determine characteristics including age, level of education and employment, known average knowledge of BSE before and after intervention using an application, and a more effective breast examination assistance model by measuring the level of BSE knowledge in adolescents at SMAN-1 Katingan Tengah. This research is a research that uses a descriptive method with data analysis used is univariate and bivariate with a two-mean difference test and statistics. The research sample consisted of 30 young women and 30 parents (mothers) using a random sampling technique. The results showed that most of the young women had good knowledge before the intervention of 30.0% with an average of 13.17 and after being given intervention through the application increased to 100% with an average of 19.07 and some parents (mothers) had good knowledge before the intervention 20, 0% with an average of 12.63 and after being given intervention through family assistance increased to 100% with an average of 17.97. Comparison of the average value after the intervention of the effectiveness of the breast self-examination assistance model (BSE) by group with a difference of 1.1. And it is proven statistically where the value is (p = 0.000).

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