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Cytotoxicity of Kelakai (Stenochlaena palustris) Extract to MCF-7 Breast Cancer Cell Harlyanti Muthma'innah Mashar; Itma Annah
Jurnal Fitofarmaka Indonesia Vol 7, No 3 (2020): JURNAL FITOFARMAKA INDONESIA (English Edition)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i3.590

Abstract

Breast cancer is reported to rank fifth among all types of cancer with a case of death of 6.6%. In the Central Kalimantan region, early examinations of cancers including breast cancer were carried out and 247 tumors in the breast were identified (1.76%). Kelakai (Stenochlaena palustris) as one of the typical plants of Kalimantan which contain natural chemical constituents has been reported to be effective as an anti-inflammatory and antioxidant, so that with this potential can be developed to overcome diseases associated with it, one of them is breast cancer. This study aimed to examine the cytotoxicity of MCF-7 breast cancer cells using ethanol extract. The cytotoxicity assay of kelakai extract against MCF-7 cells conducted in vitro by the MTT reduction method. The variation of concentration used is 1000; 500; 250; 125; 62.5; 31.5; and 15.625 µg/ml, doxorubicin as a positive control was performed in a concentration of 1 μg / ml. The results of the cytotoxicity assay showed that the kelakai extract had a toxic effect on MCF-7 cells with an IC50 value of 493.57 µg / ml.
Memasyarakatkan Tanya 5O Dan Efek Interaksi Obat Pada Siswa MTsN 2 Kota Palangka Raya: Promoting “Tanya 5 O” and Effects of Drugs on Nutritional Status in Students of MTsN 2 Palangka Raya Harlyanti Muthma'innah Mashar; Normila Normila; Juni Ramadhani; Dali Dali; Ismail Ismail
Jurnal Mandala Pengabdian Masyarakat Vol. 2 No. 1 (2021): Jurnal Mandala Pengabdian Masrakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1127.491 KB) | DOI: 10.35311/jmpm.v2i1.27

Abstract

This community service is a form of sharing program of cooperation from the Ministry of Health of the Republic of Indonesia and the Provincial and City Health Offices, namely GeMa CerMat (Smart Community Movement Using Drugs), one of which is through the promotion of the tagline "Tanya Lima O". Through this tagline, it is hoped that the public can be more active in seeking information about drugs, not only for health workers but also from other valid and trustworthy sources. Apart from this information, people also need to know drug interactions, especially drug interactions with food. To achieve quality and safe drug use, active community involvement is highly expected. In this activity, the target audience is students at MTsN 2 Palangka Raya. The method is in the form of the posttest and pretest implementation, interactive counseling with participants, as well as discussion and question and answer. The value obtained from the posttest and pretest results was then performed statistical tests using the paired T-test and the Gain test. Based on the results of the analysis, it was found that there was a significant difference in knowledge between before and after counseling was given. This is evidenced by the increase in post-test scores. The average posttest score was 80, and this value was greater than the pretest average score of 44. The results of the analysis with the paired T-test obtained p-value = 0.000, indicating a significant difference in knowledge between before and after counseling. The value of understanding that increased after being given counseling was shown by a percentage of 87.69%, consisting of 25 people (38.46%) who obtained high gain values ??and 32 people (49.23%) moderate gain values.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JARAK MERAH (Jatropha gossypiifolia) ASAL KABUPATEN BANTAENG Nurzadrina Wahyuddin; Ismail Ismail; Harlyanti Muthma'innah Mashar; Dali
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.115

Abstract

Background: In the last few decades there has been an increase in cases of chronic diseases and premature aging which are some of the key factors in influencing public health. This condition is caused by various causes, but the main factor is the number of free radicals that exceed the body's capacity to neutralize them. Antioxidants have an important role as health protective factors because they can neutralize and protect cells from the presence of free radicals. Red castor leaves have been reported to have good activity as an antioxidant. The chemical content of this plant is anthraquinone, flavonoid, saponin, tannin and terpenoid. Objective: This study aimed to evaluate the antioxidant activity of red jatropha leaf extract using the DPPH method. Methods Samples were extracted using 70% ethanol by maceration method. The antioxidant activity test was carried out using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) using a comparison of Vitamin C. Each test used a variation of the concentration of the solution. For red jatropha leaf extract using concentration variations of 20, 40, 60, 80 and 100 g/ml, while for vitamin C using concentration variations of 10, 15, 20, 25, and 30 g/ml. The absorbance of each test solution was measured using a spectrophotometer at a wavelength of 515 nm. The results are reported as IC50 values. Results: The results showed that the IC50 values ​​of red jatropha leaf extract and vitamin C were 47.81 and 14.99 g/ml, respectively. This value indicates that the Chinese jatropha leaf extract has a very strong antioxidant activity (IC50 <50 g/ml). Conclusion: Red jatropha leaf extract showed very strong antioxidant activity with an IC50 value of 47.81 g/ml so it has great potential as an antioxidant that can be used for the development of traditional medicinal raw materials.
Edukasi Pencegahan Kanker Payudara dan Pengenalan Potensi Tanaman Kelakai (Stenochlaena palustris) untuk Mencegah Kanker Payudara Harlyanti Muthma'innah Mashar; Dali Dali
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 5 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i5.2002

Abstract

The incidence of breast cancer does not only occur in the age range of 30–50 years but has also been found in adolescence. It is necessary to conduct early prevention education of breast cancer and its potential as a local plant in preventing breast cancer. It is hoped that the implementation of this activity can support cancer control activities by utilizing local wisdom typical of Central Kalimantan. The target of this activity is students at MAN Palangka Raya City. Implementation methods in the form of posttest and pretest, interactive counseling through zoom applications, and discussion. The implementation of the posttest and pretest aims to see an increase in understanding after counseling. The value obtained from the posttest and pretest results was then performed statistical tests using the paired T-test. Based on the results of the analysis, it was found that there was a significant difference in knowledge between before and after counseling, as evidenced by an increase in posttest scores. The average posttest score was 85.34. This value is greater than the pretest average value of 80.01. Based on the results of the paired T-test, it is known that the p-value (asymp. sig 2 tailed) is 0.001 (p <0.05), thus it is concluded that there is a significant difference in knowledge between before extension and after counseling. As many as 80% of participants have a good level of knowledge. This has achieved an indicator of success, where more than 75% of extension participants can understand the material provided.
Edukasi Personal Hygiene pada Remaja sebagai Upaya Pencegahan Penyakit Infeksi pada Siswa SMA di Kota Palangka Raya Normila Normila; Harlyanti Muthma'innah Mashar
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 5 (2021): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v6i5.2085

Abstract

Diseases caused by negligence in maintaining personal hygiene are still a public health problem in Indonesia, one of which is school-age children. School-age children are an age group that is vulnerable to various health problems. The number of school-age children, from early childhood to adolescence, still often neglects personal hygiene. The result of poor personal hygiene can increase the risk of infection, which can lead to various diseases. For that, health-related behaviors must be applied to children as early as possible. This activity targets students at MAN Kota Palangka Raya, the adolescent age group, who often feel that they have good endurance, so they often ignore personal hygiene problems. Implementing this activity is an online extension through the zoom application, question-and-answer, and evaluation through posttest and pretest. The posttest and pretest results obtained were then performed statistical tests using the paired T-test. Based on the analysis results, there are significant differences in knowledge between before and after counseling. The average posttest score was 85.24, which was greater than the pretest average score, which was 79.92. Based on the paired T-test results, it is known that the p-value is 0.001 (p <0.05), so it can be concluded that there is a significant difference in knowledge between before and after counseling. As many as 80% of participants have a good level of knowledge.
PENGARUH PENYULUHAN GIZI DENGAN MEDIA VIDEO TERHADAP PENGETAHUAN DAN SIKAP REMAJA TENTANG KONSUMSI SAYUR DAN BUAH DI SMAN 1 PALANGKA RAYA Harlyanti Muthma'innah Mashar
Jurnal Gizi dan Pangan Soedirman Vol 5 No 2 (2021): JURNAL GIZI DAN PANGAN SOEDIRMAN
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.589 KB) | DOI: 10.20884/1.jgipas.2021.5.2.4342

Abstract

The age of 10-18 years is the age range of adolescents who are included in the period of being vulnerable to nutrition. Habits at this age are often skipping breakfast, not moving, and snacking a lot. This causes low consumption of vegetables and fruits. This study aims to analyze the effect of providing nutrition counseling using video media on the knowledge and attitudes of adolescents about vegetable and fruit consumption at SMAN 1 Palangka Raya. The design of this study was a quasi-experiment with one group pretest and posttest design with 38 subjects. The results were then analyzed using the Wilcoxon test and McNemar test. The results showed that the characteristics of the subjects were in the age group of 15-17 years with the highest number aged 16 years (68.4%). Most of the subjects were female (55.3%). The results of the statistical test obtained p = 0.000 (p <0.05) stating that there was a significant difference between knowledge before and after counseling. The results of statistical tests using McNemar's test for attitudes obtained a p-value of 0.000 (p <0.05) which indicated that there was a significant difference between attitudes before and after counseling. Based on these results, counseling with video media influences the knowledge and attitudes of adolescents regarding the consumption of vegetables and fruits at SMAN 1 Palangka Raya.
STATUS PERNIKAHAN DAN DUKUNGAN SOSIAL SUAMI TERHADAP KUALITAS HIDUP WANITA MENOPAUSE DI KOTA PALANGKA RAYA Itma Annah; Harlyanti Muthma’innah Mashar
Jurnal Surya Muda Vol 2 No 1 (2020): Jurnal Surya Muda
Publisher : LPPM STIKES Muhammadiyah Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (438.201 KB) | DOI: 10.38102/jsm.v2i1.56

Abstract

Menopause is a period of permanent cessation of the menstrual cycle, causing decreased production of the hormones estrogen, progesterone and testosterone. Some of the symptoms of menopause are hot flashes, night sweats, and vaginal atrophy resulting in vaginal dryness associated with changes in sex hormone levels resulting in decreased quality of life for menopausal women. The purpose of this study is to look at the relationship between marital status and husband's social support to the quality of life of menopausal women in Palangka Raya City. The instrument used to assess the quality of life of menopausal women is to use The Utian Quality of Life (UQOL) Scale. The research method used is a cross sectional study design. The results showed there was a relationship between marital status and the quality of life of menopausal women (p = 0,000), as well as husband's social support (p = 0,000). Therefore, it is very important that there is family support especially the husband in providing social support for menopausal women.
Pengembalian Semangat Belajar Anak-anak di Kelurahan Bontolebang Selama Masa Pandemi Ismail Ismail; Harlyanti Muthma'innah Mashar; Andi Paluseri; Lukman Muslimin; Nur Khairi; Dali Dali
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 1 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.029 KB) | DOI: 10.35311/jmpm.v3i1.42

Abstract

Motivasi belajar memiliki peran yang penting dalam proses penerimaan pelajaran yang dilakukan di sekolah. Anak-anak sudah terlalu nyaman dengan sekolah online dan tidak tatap muka sehingga pembelajaran tidak seperti biasanya ketika sedang di sekolah. Peserta kegiatan ini adalah anak-anak di lingkungan Bontopajja berjumlah 14 orang dan anak-anak di lingkungan Jamarang berjumlah 25 orang, sehingga total peserta adalah 39 orang. Pelaksanaan kegiatan dilakukan dengan metode ceramah, tutorial, serta diskusi dan tanya jawab. Kegiatan ini terlaksana dengan baik dan lancar. Seluruh peserta dapat mengikuti dengan baik dan sangat aktif berperan serta selama kegiatan berlangsung. Anak-anak di lingkungan Boontopajja dan di lingkungan Jamarang bersemangat dalam mengikuti kegiatan ini dengan bermain sambil belajar. Kegiatan ini dapat memberikan motivasi belajar sehingga dapat menghasilkan pengaruh yang positif dan signifikan terhadap hasil belajar siswa. Berdasarkan hal tersebut, kegiatan pengembalian semangat belajar yang dilakukan telah sesuai. Kegiatan ini terlaksana dengan baik dan lancar. Seluruh peserta dapat mengikuti dengan baik dan sangat aktif berperan serta selama kegiatan berlangsung. Anak-anak di lingkungan Boontopajja dan di lingkungan Jamarang bersemangat dalam mengikuti kegiatan ini dengan bermain sambil belajar.
Penyuluhan Tentang DAGUSIBU (Dapat, Gunakan, Simpan. Buang) Obat di Kecamatan Sanrobone Nurzadrina Wahyuddin; Mirnawati Salampe; Akbar Awaluddin; Andi Paluseri; Lukman Muslimin; Ismail Ismail; Nur Khairi; Harlyanti Muthma'innah Mashar; Dali Dali
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 1 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (856.896 KB) | DOI: 10.35311/jmpm.v3i1.44

Abstract

Obat-obatan secara umum digunakan untuk meningkatkan kesehatan dan mencegah penyakit. Pengawasan penggunaan obat-obatan saat ini dilakukan dengan memperkenalkan istilah DAGUSIBU (Dapatkan, Gunakan, Simpan dan Buang) oleh Ikatan Apoteker Indonesia dalam rangka menjamin keamanan masyarakat. Masalah penyalahgunaan obat-obatan di masyarakat merupakan faktor yang perlu menjadi perhatian terutama daerah pedesaan dengan fasilitas kesehatan terbatas. Tujuan sosialisasi ini adalah untuk meningkatkan pengetahuan dan pemahaman masyarakat tentang obat melalui sosialisasi DAGUSIBU di Desa Puasana, Kec. Moramo Utara, Kab. Konawe Selatan. Metode pelaksanaan kegiatan dilakukan melalui sosialisasi atau ceramah serta diskusi interaktif. Kegiatan sosialisasi ini terlaksana dengan baik terlihat dari respon dan antusias warga dalam mengikuti sosialisasi, memberikan pertanyaan dan aktif dalam diskusi mengenai cara mendapatkan, menggunakan, menyimpan dan membuang obat yang baik dan benar.
Perbedaan Kualitas Hidup Wanita Menopause Daerah Urban dan Rural Itma Annah; Harlyanti Muthma’innah Mashar; Irene Febriani; Destinady Kadiser Miden
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 11 No 2 (2021): April 2021
Publisher : LPPM STIKES KENDAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v11i2.1228

Abstract

Diperkirakan secara global angka populasi wanita berumur 50 tahun atau lebih akan meningkat menjadi 1,2 milyar pada tahun 2030. Yang berarti adanya peningkatan angka harapan hidup pada wanita maka akan berpengaruh pula pada banyaknya wanita yang akan mengalami menopause pada sepertiga hidupnya. Kejadian menopause berhubungan dengan perubahan kadar hormon seks sehingga mengakibatkan penurunan kualitas hidup wanita menopause. Tujuan penelitian ini ialah untuk melihat perbedaan kualitas hidup wanita menopause di derah urban dan rural Kota Palangka Raya, dan melihat faktor-faktor yang berhubungan dengan kualitas hidup Instrumen yang digunakan untuk menilai kualitas hidup wanita menopause adalah menggunakan The Utian Quality of Life (UQOL) Scale. Populasi dalam penelitian ini adalah seluruh kunjungan pasien menopause di Puskesmas Menteng dan Puskesmas Kereng Bangkirai. Peneliti menggunakan sampel minimal size dengan perhitungan sampel 30/kelompok. Tehnik pengambilan sampel adalah dengan menggunakan metode accidental sampling. Metode penelitian yang digunakan ialah uji t tidak berpasangan untuk membandingkan kualitas hidup wanita menopause daerah rural dan urban dan desain studi cross sectional untuk melihat faktor-faktor yang berhubungan dengan kualitas hidup wanita menopause. Hasil penelitian menunjukkan ada perbedaan kualitas hidup wanita menopause daerah rural dan urban (perbedaan nilai mean= 14,28 dan p =0,007), dan faktor yang berhubungan dengan kualitas hidup wanita menopause adalah tingkat pendidikan (p=0,015), riwayat penyakit responden (p=0,000). Dapat disimpulkan bahwa ada perbedaan kualitas hidup daerah urban dan rural, yang mana kualitas hidup wanita menopause daerah urban cenderung lebih baik dibandingkan daerah rural.