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All Journal Jurnal Fitofarmaka Indonesia Jurnal Sains dan Kesehatan
Haeria Haeria
UIN Alauddin Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Aktivitas Antiplasmodium Dari Isolat Kulit Batang Kayu Tammate (Lannea coromandelica Houtt. Merr.) Secara In-Vitro Karlina Amir Tahir; Haeria Haeria; Alifia Putri Febriyanti; St. Chadijah; Nursalam Hamzah
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.203 KB) | DOI: 10.33096/jffi.v7i1.591

Abstract

One of the main causes of death and a major public health problem is malaria. Some drug resistance and the limited number of effective drugs have given the community a sense of worry. This makes the discovery of new antimalarial compounds very necessary. Based on the results of exploration of natural materials, Javanese wood is one of the plants that is efficacious as an antimicrobial and is thought to be efficacious as antiplasmodium. This study was then conducted to find hexan and ethyl acetate isolates from the Java wood fraction (Lannea coromandelica Houtt. Merr.) Which effectively inhibited the development of Plasmodium falciparum in vitro. This research is a follow-up study from previous studies in testing the fraction of Javanese bark against antioxidant activity. The procedure starts from hexan and ethyl acetate isolates with five concentrations of 10 (µg / ml), 1 (µg / ml), 0.1 (µg / ml), 0.01 (µg / ml) and 0.001 (µg / ml) 3D7 strain of Plasmodium falciparum was measured based on the average percent resistance. The results of this study indicate that etil asetat isolate have IC50 2,727 µg/ml, its mean moderate activity as antiplasmodium. While hexan isolate have IC50 >10 µg/ml its mean not have or low antiplasmodium activity.
Pengaruh Perbandingan Konsentrasi Polimer terhadap Karakteristik dan Laju Pelepasan Patch Transdermal Nifedipin: The Effect of Comparison Polymer Concentrations on the Characteristics and Release Rate of the Transdermal Nifedipin Patch Nur Azizah Syahrana; Surya Ningsi; Haeria Haeria; Isriany Ismail
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.337 KB)

Abstract

Nifedipine is a dihydropyridine anti-hypertensive drug as a calcium channel blocker with low oral biovaibility and a short half-life resulting in frequent repeated daily use of the drug when given orally in conventional dosage forms. The matrix system transdermal patch is an option that allows controlled delivery of the drug through the skin and provides patient comfort. The purpose of this study was to determine the effect of polymer deposition on the material and the in-vitro release rate of nifedipine transdermal patches with the polymer ratio of Ethyl Cellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) used, namely F1 (7:3), F2 (8:2) and F3 (9:1). The results of the nifedipine patch test on organoleptic examination are round, characteristic odor, yellow color and smooth surface texture. In vitro release showed that the best polymer was found in Formula 2 EC: HPMC (8:2) with good characteristics and the highest flux value was 1.307 (µg.cm-2 min-1).
Co-Authors Alifia Putri Febriyanti Isriany Ismail Karlina Amir Tahir Nur Azizah Syahrana Nursalam Hamzah St. Chadijah Surya Ningsi