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Surya Ningsi
UIN Alauddin Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KARAKTERISASI MIKROKRISTALIN SELULOSA DARI KULIT JAGUNG PULUT (Zea mays L. Var Ceratina Kulesh) Surya Ningsi; Nining Iklasita; Munifah Wahyuddin; Syamsuri Syakri
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.15294

Abstract

Corn husk is a part of the plant that has a high cellulose fiber content, which is around 44.08%, so it is potentially to be used as a source of raw material of microcrystalline cellulose. The purpose of this research was to synthesize and determine the characteristics of microcrystalline cellulose produced from corn husk. The making of microcrystalline cellulose was carried out in two stages, namely delignification using NaOH solvent with five variations of concentration (7,5%, 10%, 12,5%, 15% and 17,5%) and hydrolyzed using 2,5 N HCl. Characteristic test for microcrystalline cellulose included organoleptic, pH, flow time and stationary angle, FTIR, and XRD. The results showed that microcrystalline cellulose produced from corn husk had characteristics such as fine powder, white and odorless, pH was 7.0, flow time was 0.3 g/sec, a stationary angle was 54o, FTIR analysis showed a typical peak of cellulose namely 3411,05 for O-H and 2900,61 for C-H, with a crystallinity degree was 79%.
Pengaruh Perbandingan Konsentrasi Polimer terhadap Karakteristik dan Laju Pelepasan Patch Transdermal Nifedipin: The Effect of Comparison Polymer Concentrations on the Characteristics and Release Rate of the Transdermal Nifedipin Patch Nur Azizah Syahrana; Surya Ningsi; Haeria Haeria; Isriany Ismail
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.337 KB)

Abstract

Nifedipine is a dihydropyridine anti-hypertensive drug as a calcium channel blocker with low oral biovaibility and a short half-life resulting in frequent repeated daily use of the drug when given orally in conventional dosage forms. The matrix system transdermal patch is an option that allows controlled delivery of the drug through the skin and provides patient comfort. The purpose of this study was to determine the effect of polymer deposition on the material and the in-vitro release rate of nifedipine transdermal patches with the polymer ratio of Ethyl Cellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) used, namely F1 (7:3), F2 (8:2) and F3 (9:1). The results of the nifedipine patch test on organoleptic examination are round, characteristic odor, yellow color and smooth surface texture. In vitro release showed that the best polymer was found in Formula 2 EC: HPMC (8:2) with good characteristics and the highest flux value was 1.307 (µg.cm-2 min-1).
Co-Authors Haeria Haeria Isriany Ismail Munifah Wahyuddin Nining Iklasita Nur Azizah Syahrana Syamsuri Syakri